Has-miR-129-5p’s Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative Diseases
At present, it is necessary to identify specific biochemical, molecular, and genetic markers that can reliably aid in screening digestive cancer and correlate with the degree of disease development. Has-miR-129-5p is a small, non-coding molecule of RNA, circulating in plasma, gastric juice, and othe...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/7/2058 |
| _version_ | 1797590126680866816 |
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| author | Adrian Boicean Sabrina Birsan Cristian Ichim Ioana Boeras Iulian Roman-Filip Grama Blanca Ciprian Bacila Radu Sorin Fleaca Horatiu Dura Corina Roman-Filip |
| author_facet | Adrian Boicean Sabrina Birsan Cristian Ichim Ioana Boeras Iulian Roman-Filip Grama Blanca Ciprian Bacila Radu Sorin Fleaca Horatiu Dura Corina Roman-Filip |
| author_sort | Adrian Boicean |
| collection | DOAJ |
| description | At present, it is necessary to identify specific biochemical, molecular, and genetic markers that can reliably aid in screening digestive cancer and correlate with the degree of disease development. Has-miR-129-5p is a small, non-coding molecule of RNA, circulating in plasma, gastric juice, and other biological fluids; it plays a protective role in tumoral growth, metastasis, etc. Furthermore, it is involved in various diseases, from the development of digestive cancer in cases of downregulation to neurodegenerative diseases and depression. Methods: We examined meta-analyses, research, and studies related to miR-129-5-p involved in digestive cancer and its implications in cancer processes, as well as metastasis, and described its implications in neurological diseases. Conclusions: Our review outlines that miR-129-5p is a significant controller of different pathways, genes, and proteins and influences different diseases. Some important pathways include the WNT and PI3K/AKT/mTOR pathways; their dysregulation results in digestive neoplasia and neurodegenerative diseases. |
| first_indexed | 2024-03-11T01:17:03Z |
| format | Article |
| id | doaj.art-cfa1e677391441ee908a6407b4940b4f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T01:17:03Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-cfa1e677391441ee908a6407b4940b4f2023-11-18T18:28:52ZengMDPI AGBiomedicines2227-90592023-07-01117205810.3390/biomedicines11072058Has-miR-129-5p’s Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative DiseasesAdrian Boicean0Sabrina Birsan1Cristian Ichim2Ioana Boeras3Iulian Roman-Filip4Grama Blanca5Ciprian Bacila6Radu Sorin Fleaca7Horatiu Dura8Corina Roman-Filip9Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, RomaniaMolecular Biology Laboratory of the Applied Ecology Research Center, Faculty of Sciences, Lucian Blaga University of Sibiu, 550012 Sibiu, RomaniaDepartment of Neurology, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540136 Targu Mures, RomaniaFaculty of Social Sciences, Lucian Blaga University of Sibiu, 550012 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, RomaniaAt present, it is necessary to identify specific biochemical, molecular, and genetic markers that can reliably aid in screening digestive cancer and correlate with the degree of disease development. Has-miR-129-5p is a small, non-coding molecule of RNA, circulating in plasma, gastric juice, and other biological fluids; it plays a protective role in tumoral growth, metastasis, etc. Furthermore, it is involved in various diseases, from the development of digestive cancer in cases of downregulation to neurodegenerative diseases and depression. Methods: We examined meta-analyses, research, and studies related to miR-129-5-p involved in digestive cancer and its implications in cancer processes, as well as metastasis, and described its implications in neurological diseases. Conclusions: Our review outlines that miR-129-5p is a significant controller of different pathways, genes, and proteins and influences different diseases. Some important pathways include the WNT and PI3K/AKT/mTOR pathways; their dysregulation results in digestive neoplasia and neurodegenerative diseases.https://www.mdpi.com/2227-9059/11/7/2058miR-129-5pdownregulationdigestive neoplasianeurological diseases |
| spellingShingle | Adrian Boicean Sabrina Birsan Cristian Ichim Ioana Boeras Iulian Roman-Filip Grama Blanca Ciprian Bacila Radu Sorin Fleaca Horatiu Dura Corina Roman-Filip Has-miR-129-5p’s Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative Diseases Biomedicines miR-129-5p downregulation digestive neoplasia neurological diseases |
| title | Has-miR-129-5p’s Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative Diseases |
| title_full | Has-miR-129-5p’s Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative Diseases |
| title_fullStr | Has-miR-129-5p’s Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative Diseases |
| title_full_unstemmed | Has-miR-129-5p’s Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative Diseases |
| title_short | Has-miR-129-5p’s Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative Diseases |
| title_sort | has mir 129 5p s involvement in different disorders from digestive cancer to neurodegenerative diseases |
| topic | miR-129-5p downregulation digestive neoplasia neurological diseases |
| url | https://www.mdpi.com/2227-9059/11/7/2058 |
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