SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver
Transition metals such as iron, copper and zinc are required for the normal functioning of biological tissues, whereas others, such as cadmium, are potentially highly toxic. Any disturbances in homeostasis caused by lack of micronutrients in the diet, pollution or genetic heredity result in malfunct...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/4/846 |
| _version_ | 1797606666328342528 |
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| author | Marko Z. Vatamaniuk Rong Huang Zeping Zhao Xin Gen Lei |
| author_facet | Marko Z. Vatamaniuk Rong Huang Zeping Zhao Xin Gen Lei |
| author_sort | Marko Z. Vatamaniuk |
| collection | DOAJ |
| description | Transition metals such as iron, copper and zinc are required for the normal functioning of biological tissues, whereas others, such as cadmium, are potentially highly toxic. Any disturbances in homeostasis caused by lack of micronutrients in the diet, pollution or genetic heredity result in malfunction and/or diseases. Here, we used synchrotron X-ray fluorescence, SXRF, microscopy and mice with altered functions of major antioxidant enzymes to show that SXRF may become a powerful tool to study biologically relevant metal balance in the pancreas and liver of mice models with disturbed glucose homeostasis. |
| first_indexed | 2024-03-11T05:18:22Z |
| format | Article |
| id | doaj.art-cfa21ee6d3e3433bbc954411b73d5dea |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T05:18:22Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-cfa21ee6d3e3433bbc954411b73d5dea2023-11-17T18:05:08ZengMDPI AGAntioxidants2076-39212023-04-0112484610.3390/antiox12040846SXRF for Studying the Distribution of Trace Metals in the Pancreas and LiverMarko Z. Vatamaniuk0Rong Huang1Zeping Zhao2Xin Gen Lei3Animal Science Department, Cornell University, Ithaca, NY 14853, USACornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, NY 14850, USAAnimal Science Department, Cornell University, Ithaca, NY 14853, USAAnimal Science Department, Cornell University, Ithaca, NY 14853, USATransition metals such as iron, copper and zinc are required for the normal functioning of biological tissues, whereas others, such as cadmium, are potentially highly toxic. Any disturbances in homeostasis caused by lack of micronutrients in the diet, pollution or genetic heredity result in malfunction and/or diseases. Here, we used synchrotron X-ray fluorescence, SXRF, microscopy and mice with altered functions of major antioxidant enzymes to show that SXRF may become a powerful tool to study biologically relevant metal balance in the pancreas and liver of mice models with disturbed glucose homeostasis.https://www.mdpi.com/2076-3921/12/4/846transition metalsX-ray fluorescencepancreasliver |
| spellingShingle | Marko Z. Vatamaniuk Rong Huang Zeping Zhao Xin Gen Lei SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver Antioxidants transition metals X-ray fluorescence pancreas liver |
| title | SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver |
| title_full | SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver |
| title_fullStr | SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver |
| title_full_unstemmed | SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver |
| title_short | SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver |
| title_sort | sxrf for studying the distribution of trace metals in the pancreas and liver |
| topic | transition metals X-ray fluorescence pancreas liver |
| url | https://www.mdpi.com/2076-3921/12/4/846 |
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