Immunogenic effects of chemotherapy-induced tumor cell death
Emerging evidence suggests that the clinical success of conventional chemotherapy is not solely attributed to tumor cell toxicity, but also results from the restoration of immunosurveillance, which has been largely neglected in the past preclinical and clinical research. Antitumor immune response ca...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2018-09-01
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| Series: | Genes and Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304218300679 |
| _version_ | 1797710121261858816 |
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| author | Yi-Jun Wang Rochelle Fletcher Jian Yu Lin Zhang |
| author_facet | Yi-Jun Wang Rochelle Fletcher Jian Yu Lin Zhang |
| author_sort | Yi-Jun Wang |
| collection | DOAJ |
| description | Emerging evidence suggests that the clinical success of conventional chemotherapy is not solely attributed to tumor cell toxicity, but also results from the restoration of immunosurveillance, which has been largely neglected in the past preclinical and clinical research. Antitumor immune response can be primed by immunogenic cell death (ICD), a type of cell death characterized by cell-surface translocation of calreticulin (CRT), extracellular release of ATP and high mobility group box 1 (HMGB1), and stimulation of type I interferon (IFN) responses. Here we summarize recent studies showing conventional chemotherapeutics as ICD inducers, which are capable of modulating tumor infiltrating lymphocytes (TILs) and reactivating antitumor immunity within an immuno-suppressive microenvironment. Such immunological effects of conventional chemotherapy are likely critical for better prognosis of cancer patients. Furthermore, combination of ICD-inducing chemotherapeutics with immunotherapy is a promising approach for improving the clinical outcomes of cancer patients. Keywords: Antitumor immunity, Autophagy, Conventional chemotherapy, ER stress, Immunogenic cell death, Immunosurveillance |
| first_indexed | 2024-03-12T06:47:38Z |
| format | Article |
| id | doaj.art-cfa38bb4d9e34c6db7a4202fd6c7c5d1 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T06:47:38Z |
| publishDate | 2018-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-cfa38bb4d9e34c6db7a4202fd6c7c5d12023-09-03T00:30:36ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422018-09-0153194203Immunogenic effects of chemotherapy-induced tumor cell deathYi-Jun Wang0Rochelle Fletcher1Jian Yu2Lin Zhang3UPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USAUPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USAUPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USAUPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA; Corresponding author. UPMC Hillman Cancer Center Research Pavilion, Room 2.42a, 5117 Centre Ave, Pittsburgh, PA, 15213, USA. Fax: +412 623 7778.Emerging evidence suggests that the clinical success of conventional chemotherapy is not solely attributed to tumor cell toxicity, but also results from the restoration of immunosurveillance, which has been largely neglected in the past preclinical and clinical research. Antitumor immune response can be primed by immunogenic cell death (ICD), a type of cell death characterized by cell-surface translocation of calreticulin (CRT), extracellular release of ATP and high mobility group box 1 (HMGB1), and stimulation of type I interferon (IFN) responses. Here we summarize recent studies showing conventional chemotherapeutics as ICD inducers, which are capable of modulating tumor infiltrating lymphocytes (TILs) and reactivating antitumor immunity within an immuno-suppressive microenvironment. Such immunological effects of conventional chemotherapy are likely critical for better prognosis of cancer patients. Furthermore, combination of ICD-inducing chemotherapeutics with immunotherapy is a promising approach for improving the clinical outcomes of cancer patients. Keywords: Antitumor immunity, Autophagy, Conventional chemotherapy, ER stress, Immunogenic cell death, Immunosurveillancehttp://www.sciencedirect.com/science/article/pii/S2352304218300679 |
| spellingShingle | Yi-Jun Wang Rochelle Fletcher Jian Yu Lin Zhang Immunogenic effects of chemotherapy-induced tumor cell death Genes and Diseases |
| title | Immunogenic effects of chemotherapy-induced tumor cell death |
| title_full | Immunogenic effects of chemotherapy-induced tumor cell death |
| title_fullStr | Immunogenic effects of chemotherapy-induced tumor cell death |
| title_full_unstemmed | Immunogenic effects of chemotherapy-induced tumor cell death |
| title_short | Immunogenic effects of chemotherapy-induced tumor cell death |
| title_sort | immunogenic effects of chemotherapy induced tumor cell death |
| url | http://www.sciencedirect.com/science/article/pii/S2352304218300679 |
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