Transcriptional co‐activators YAP1–TAZ of Hippo signalling in doxorubicin‐induced cardiomyopathy

Transcriptional co‐activators YAP1–TAZ of Hippo signalling in doxorubicin‐induced cardiomyopathy

Abstract Aims Hippo signalling is an evolutionarily conserved pathway that controls organ size by regulating apoptosis, cell proliferation, and stem cell self‐renewal. Recently, the pathway has been shown to exert powerful growth regulatory activity in cardiomyocytes. However, the functional role of...

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Bibliographic Details
Main Authors: Tünde Berecz, Angela Yiu, Orsolya Vittay, Barbara Orsolits, Maxime Mioulane, Cristobal G. dosRemedios, Robin Ketteler, Bela Merkely, Ágota Apáti, Sian E. Harding, Nicola Hellen, Gabor Foldes
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:ESC Heart Failure
Subjects:
Hippo signalling
YAP/TAZ
Human pluripotent stem cell‐derived cardiomyocytes
Doxorubicin‐induced cardiotoxicity
Online Access:https://doi.org/10.1002/ehf2.13756

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