Advances in the Mechanism of Lactobacillus rhamnosus GG Improving Inflammatory Bowel Disease
China is seeing an increasing prevalence of inflammatory bowel disease (IBD) . During the process of exploring treatments for IBD, gut microbiota has been found to be crucial to the development of IBD along with the discovery of microbial-host interactions, suggesting that modulating gut microbiota...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2022-12-01
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| Series: | Zhongguo quanke yixue |
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| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220330.pdf |
| _version_ | 1797216927026774016 |
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| author | CEN Qiuyu, PANG Rizhao, CUI Yanru, WEI Juanfang, ZHANG Anren |
| author_facet | CEN Qiuyu, PANG Rizhao, CUI Yanru, WEI Juanfang, ZHANG Anren |
| author_sort | CEN Qiuyu, PANG Rizhao, CUI Yanru, WEI Juanfang, ZHANG Anren |
| collection | DOAJ |
| description | China is seeing an increasing prevalence of inflammatory bowel disease (IBD) . During the process of exploring treatments for IBD, gut microbiota has been found to be crucial to the development of IBD along with the discovery of microbial-host interactions, suggesting that modulating gut microbiota may be a new strategy for the treatment of IBD. Recent studies have shown that Lactobacillus rhamnosus GG (LGG) , one most widely used probiotic strain, can achieve IBD alleviation by regulating intestinal microbial composition, maintaining intestinal epithelial barrier integrity, modulating intestinal immune response, inhibiting oxidative stress, and improving anxiety-depression status. Therefore, this paper presents a review of the mechanism of action of LGG in improving IBD, providing theoretical support for its clinical application. |
| first_indexed | 2024-04-24T11:53:44Z |
| format | Article |
| id | doaj.art-cfa688211b0e4cd3a71d1426872e4629 |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:53:44Z |
| publishDate | 2022-12-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-cfa688211b0e4cd3a71d1426872e46292024-04-09T06:41:42ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722022-12-0125364595460010.12114/j.issn.1007-9572.2022.0330Advances in the Mechanism of Lactobacillus rhamnosus GG Improving Inflammatory Bowel DiseaseCEN Qiuyu, PANG Rizhao, CUI Yanru, WEI Juanfang, ZHANG Anren01.School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China;2.Department of Rehabilitation Medicine, General Hospital of the Western Theater of the Chinese People's Liberation Army, Chengdu 610083, China;3.Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai 200434, ChinaChina is seeing an increasing prevalence of inflammatory bowel disease (IBD) . During the process of exploring treatments for IBD, gut microbiota has been found to be crucial to the development of IBD along with the discovery of microbial-host interactions, suggesting that modulating gut microbiota may be a new strategy for the treatment of IBD. Recent studies have shown that Lactobacillus rhamnosus GG (LGG) , one most widely used probiotic strain, can achieve IBD alleviation by regulating intestinal microbial composition, maintaining intestinal epithelial barrier integrity, modulating intestinal immune response, inhibiting oxidative stress, and improving anxiety-depression status. Therefore, this paper presents a review of the mechanism of action of LGG in improving IBD, providing theoretical support for its clinical application.https://www.chinagp.net/fileup/1007-9572/PDF/zx20220330.pdfintestinal diseases|inflammatory bowel disease|lactobacillus rhamnosus|gastrointestinal microbiome|gut-brain axis |
| spellingShingle | CEN Qiuyu, PANG Rizhao, CUI Yanru, WEI Juanfang, ZHANG Anren Advances in the Mechanism of Lactobacillus rhamnosus GG Improving Inflammatory Bowel Disease Zhongguo quanke yixue intestinal diseases|inflammatory bowel disease|lactobacillus rhamnosus|gastrointestinal microbiome|gut-brain axis |
| title | Advances in the Mechanism of Lactobacillus rhamnosus GG Improving Inflammatory Bowel Disease |
| title_full | Advances in the Mechanism of Lactobacillus rhamnosus GG Improving Inflammatory Bowel Disease |
| title_fullStr | Advances in the Mechanism of Lactobacillus rhamnosus GG Improving Inflammatory Bowel Disease |
| title_full_unstemmed | Advances in the Mechanism of Lactobacillus rhamnosus GG Improving Inflammatory Bowel Disease |
| title_short | Advances in the Mechanism of Lactobacillus rhamnosus GG Improving Inflammatory Bowel Disease |
| title_sort | advances in the mechanism of lactobacillus rhamnosus gg improving inflammatory bowel disease |
| topic | intestinal diseases|inflammatory bowel disease|lactobacillus rhamnosus|gastrointestinal microbiome|gut-brain axis |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220330.pdf |
| work_keys_str_mv | AT cenqiuyupangrizhaocuiyanruweijuanfangzhanganren advancesinthemechanismoflactobacillusrhamnosusggimprovinginflammatoryboweldisease |