UBE2S promotes malignant properties via VHL/HIF‐1α and VHL/JAK2/STAT3 signaling pathways and decreases sensitivity to sorafenib in hepatocellular carcinoma

UBE2S promotes malignant properties via VHL/HIF‐1α and VHL/JAK2/STAT3 signaling pathways and decreases sensitivity to sorafenib in hepatocellular carcinoma

Abstract Background Ubiquitin‐conjugating enzyme E2S (UBE2S), an E2 enzyme, is associated with the development of various tumors and exerts oncogenic activities. UBE2S is overexpressed in tumors, including hepatocellular carcinoma (HCC). However, the key molecular mechanisms of UBE2S in HCC still ne...

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Bibliographic Details
Main Authors: Junyi Wu, Xiangjie Xu, Shasha Wu, Weiwei Shi, Guang Zhang, Yin Cao, Zhongxia Wang, Junhua Wu, Chunping Jiang
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Cancer Medicine
Subjects:
malignant properties
sorafenib
UBE2S
VHL
Online Access:https://doi.org/10.1002/cam4.6431

Internet

https://doi.org/10.1002/cam4.6431

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