Autophagy and mechanisms of effective immunity.
Macroautophagy (autophagy) is a cellular pathway facilitating several critical functions. First, by acting to ensure the degradation of damaged cellular content, autophagy is an important mechanism of intracellular homeostasis. Second, autophagy is a major trafficking pathway, shuttling content betw...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00060/full |
| _version_ | 1819091010846720000 |
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| author | Justine eMintern Jose A. Villadangos Jose A. Villadangos |
| author_facet | Justine eMintern Jose A. Villadangos Jose A. Villadangos |
| author_sort | Justine eMintern |
| collection | DOAJ |
| description | Macroautophagy (autophagy) is a cellular pathway facilitating several critical functions. First, by acting to ensure the degradation of damaged cellular content, autophagy is an important mechanism of intracellular homeostasis. Second, autophagy is a major trafficking pathway, shuttling content between the cytosol and the lysosomal compartment. Given these two key roles, autophagy can have significant and sometimes unexpected consequences on mechanisms that initiate robust immunity. Here, we will discuss the impact of autophagy on pathways of innate and adaptive immune responses including inflammatory cytokine production, antigen processing and T and B lymphocyte immunity. |
| first_indexed | 2024-12-21T22:32:56Z |
| format | Article |
| id | doaj.art-cfa9a517f3384fb59cff16f90105aa16 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T22:32:56Z |
| publishDate | 2012-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-cfa9a517f3384fb59cff16f90105aa162022-12-21T18:48:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-04-01310.3389/fimmu.2012.0006022664Autophagy and mechanisms of effective immunity.Justine eMintern0Jose A. Villadangos1Jose A. Villadangos2The University of MelbourneThe University of MelbourneThe University of MelbourneMacroautophagy (autophagy) is a cellular pathway facilitating several critical functions. First, by acting to ensure the degradation of damaged cellular content, autophagy is an important mechanism of intracellular homeostasis. Second, autophagy is a major trafficking pathway, shuttling content between the cytosol and the lysosomal compartment. Given these two key roles, autophagy can have significant and sometimes unexpected consequences on mechanisms that initiate robust immunity. Here, we will discuss the impact of autophagy on pathways of innate and adaptive immune responses including inflammatory cytokine production, antigen processing and T and B lymphocyte immunity.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00060/fullAdaptive ImmunityAntigen PresentationAutophagyinnate immunityT lymphocytes |
| spellingShingle | Justine eMintern Jose A. Villadangos Jose A. Villadangos Autophagy and mechanisms of effective immunity. Frontiers in Immunology Adaptive Immunity Antigen Presentation Autophagy innate immunity T lymphocytes |
| title | Autophagy and mechanisms of effective immunity. |
| title_full | Autophagy and mechanisms of effective immunity. |
| title_fullStr | Autophagy and mechanisms of effective immunity. |
| title_full_unstemmed | Autophagy and mechanisms of effective immunity. |
| title_short | Autophagy and mechanisms of effective immunity. |
| title_sort | autophagy and mechanisms of effective immunity |
| topic | Adaptive Immunity Antigen Presentation Autophagy innate immunity T lymphocytes |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00060/full |
| work_keys_str_mv | AT justineemintern autophagyandmechanismsofeffectiveimmunity AT joseavilladangos autophagyandmechanismsofeffectiveimmunity AT joseavilladangos autophagyandmechanismsofeffectiveimmunity |