Polyethylene particles inserted over calvarium induce cancellous bone loss in femur in female mice
Focal bone resorption (osteolysis) induced by wear particles contributes to long-term orthopedic joint failure. However, the impact of focal osteolysis on remote skeletal sites has received less attention. The goal of this study was to determine the effects of polyethylene particles placed over calv...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-12-01
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| Series: | Bone Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187218300421 |
| _version_ | 1811263409477386240 |
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| author | Kenneth A. Philbrick Carmen P. Wong Arianna M. Kahler-Quesada Dawn A. Olson Adam J. Branscum Russell T. Turner Urszula T. Iwaniec |
| author_facet | Kenneth A. Philbrick Carmen P. Wong Arianna M. Kahler-Quesada Dawn A. Olson Adam J. Branscum Russell T. Turner Urszula T. Iwaniec |
| author_sort | Kenneth A. Philbrick |
| collection | DOAJ |
| description | Focal bone resorption (osteolysis) induced by wear particles contributes to long-term orthopedic joint failure. However, the impact of focal osteolysis on remote skeletal sites has received less attention. The goal of this study was to determine the effects of polyethylene particles placed over calvaria on representative axial and appendicular skeletal sites in female mice. Because recent work has identified housing temperature as an important biological variable in mice, response to particle treatment was measured in animals housed at room (22 °C) and thermoneutral (32 °C) temperature. Osteolysis was evident in skeletal tissue adjacent to particle insertion. In addition, cancellous bone loss was observed in distal femur metaphysis. The bone loss was associated with lower osteoblast-lined perimeter and lower mineralizing perimeter in distal femur, lower osteocalcin gene expression in tibia, and lower serum osteocalcin, suggesting the response was due, at least in part, to reduced bone formation. Mild cold stress induced by sub-thermoneutral housing resulted in cancellous bone loss in distal femur and lumbar vertebra but did not influence skeletal response to particles. In summary, the results indicate that focal inflammation induced by polyethylene particles has the potential to result in systemic bone loss. This is significant because bone loss is a risk factor for fracture. Keywords: Osteolysis, Bone resorption, Bone formation, Osteoporosis |
| first_indexed | 2024-04-12T19:44:39Z |
| format | Article |
| id | doaj.art-cfaa2bcc42074107a047aaffba6fb1ea |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-04-12T19:44:39Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-cfaa2bcc42074107a047aaffba6fb1ea2022-12-22T03:19:00ZengElsevierBone Reports2352-18722018-12-0198492Polyethylene particles inserted over calvarium induce cancellous bone loss in femur in female miceKenneth A. Philbrick0Carmen P. Wong1Arianna M. Kahler-Quesada2Dawn A. Olson3Adam J. Branscum4Russell T. Turner5Urszula T. Iwaniec6Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USASkeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USASkeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USASkeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USABiostatistics Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USASkeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA; Center for Healthy Aging Research, Oregon State University, Corvallis, OR 97331, USASkeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA; Center for Healthy Aging Research, Oregon State University, Corvallis, OR 97331, USA; Corresponding author at: Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA.Focal bone resorption (osteolysis) induced by wear particles contributes to long-term orthopedic joint failure. However, the impact of focal osteolysis on remote skeletal sites has received less attention. The goal of this study was to determine the effects of polyethylene particles placed over calvaria on representative axial and appendicular skeletal sites in female mice. Because recent work has identified housing temperature as an important biological variable in mice, response to particle treatment was measured in animals housed at room (22 °C) and thermoneutral (32 °C) temperature. Osteolysis was evident in skeletal tissue adjacent to particle insertion. In addition, cancellous bone loss was observed in distal femur metaphysis. The bone loss was associated with lower osteoblast-lined perimeter and lower mineralizing perimeter in distal femur, lower osteocalcin gene expression in tibia, and lower serum osteocalcin, suggesting the response was due, at least in part, to reduced bone formation. Mild cold stress induced by sub-thermoneutral housing resulted in cancellous bone loss in distal femur and lumbar vertebra but did not influence skeletal response to particles. In summary, the results indicate that focal inflammation induced by polyethylene particles has the potential to result in systemic bone loss. This is significant because bone loss is a risk factor for fracture. Keywords: Osteolysis, Bone resorption, Bone formation, Osteoporosishttp://www.sciencedirect.com/science/article/pii/S2352187218300421 |
| spellingShingle | Kenneth A. Philbrick Carmen P. Wong Arianna M. Kahler-Quesada Dawn A. Olson Adam J. Branscum Russell T. Turner Urszula T. Iwaniec Polyethylene particles inserted over calvarium induce cancellous bone loss in femur in female mice Bone Reports |
| title | Polyethylene particles inserted over calvarium induce cancellous bone loss in femur in female mice |
| title_full | Polyethylene particles inserted over calvarium induce cancellous bone loss in femur in female mice |
| title_fullStr | Polyethylene particles inserted over calvarium induce cancellous bone loss in femur in female mice |
| title_full_unstemmed | Polyethylene particles inserted over calvarium induce cancellous bone loss in femur in female mice |
| title_short | Polyethylene particles inserted over calvarium induce cancellous bone loss in femur in female mice |
| title_sort | polyethylene particles inserted over calvarium induce cancellous bone loss in femur in female mice |
| url | http://www.sciencedirect.com/science/article/pii/S2352187218300421 |
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