High-efficiency production of the antimicrobial peptide pediocin PA-1 in metabolically engineered Corynebacterium glutamicum using a microaerobic process at acidic pH and elevated levels of bivalent calcium ions

High-efficiency production of the antimicrobial peptide pediocin PA-1 in metabolically engineered Corynebacterium glutamicum using a microaerobic process at acidic pH and elevated levels of bivalent calcium ions

Abstract Background Pediocin PA-1 is a bacteriocin of recognized value with applications in food bio-preservation and the medical sector for the prevention of infection. To date, industrial manufacturing of pediocin PA-1 is limited by high cost and low-performance. The recent establishment of the bi...

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Bibliographic Details
Main Authors: Jens Christmann, Peng Cao, Judith Becker, Christian K. Desiderato, Oliver Goldbeck, Christian U. Riedel, Michael Kohlstedt, Christoph Wittmann
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Microbial Cell Factories
Subjects:
Corynebacterium glutamicum
Pediocin PA-1
Bioprocess
Food additive
Bacteriocin
Antimicrobial peptide
Online Access:https://doi.org/10.1186/s12934-023-02044-y

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