Synergistic Protection of L-Arginine and Vitamin E On Lipid Peroxidation of Asthenospermic Patients
Background Lipid peroxidation is known to cause various impairments to sperm cells and may play a major role in the etiology of male infertility. Asthenospermia is the main factor of male infertility and has significantly higher level of peroxidation than in normozoospermic males. Materials and me...
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| Format: | Article |
| Language: | English |
| Published: |
Royan Institute (ACECR), Tehran
2008-08-01
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| Series: | International Journal of Fertility and Sterility |
| Subjects: | |
| Online Access: | http://www.ijfs.ir/article_45711_5652a5b8e1c7a4fbf75dd670c6b34c37.pdf |
| _version_ | 1818115191164895232 |
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| author | Sudha Srivastava |
| author_facet | Sudha Srivastava |
| author_sort | Sudha Srivastava |
| collection | DOAJ |
| description | Background
Lipid peroxidation is known to cause various impairments to sperm cells and may play a major role in the etiology of male infertility. Asthenospermia is the main factor of male infertility and has significantly higher level of peroxidation than in normozoospermic males.
Materials and methods
Using thiobarbituric acid (TBA) assay procedure, we have determined the level of lipid peroxidation as indicated by malondialdehyde (MDA) in the spermatozoa obtained from asthenospermic male semen.
Results
An inverse correlation of MDA concentration with sperm motility is observed. Treatment of cells with L-arginine and vitamin E significantly decreases the MDA concentration and improves the sperm motility as compared to that in case of control samples. A combination of L-arginine and vitamin E shows synergistic effect on sperm motility and prevention of lipid peroxidation.
Conclusion
L-arginine and vitamin E protect the cells against the loss of sperm motility by lipid peroxidation. Therefore, supplementation of both L-arginine and vitamin E may improve sperm motility and increase the possibility of fertilization in asthenospermic subjects. |
| first_indexed | 2024-12-11T04:02:42Z |
| format | Article |
| id | doaj.art-cfac532dbbd84566a7465a9e3b00f24e |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-12-11T04:02:42Z |
| publishDate | 2008-08-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-cfac532dbbd84566a7465a9e3b00f24e2022-12-22T01:21:36ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782008-08-0122606510.22074/ijfs.2008.4571145711Synergistic Protection of L-Arginine and Vitamin E On Lipid Peroxidation of Asthenospermic PatientsSudha Srivastava0National Facility for High Field NMR, Tata Institute of Fundamental Research, Mumbai, IndiaBackground Lipid peroxidation is known to cause various impairments to sperm cells and may play a major role in the etiology of male infertility. Asthenospermia is the main factor of male infertility and has significantly higher level of peroxidation than in normozoospermic males. Materials and methods Using thiobarbituric acid (TBA) assay procedure, we have determined the level of lipid peroxidation as indicated by malondialdehyde (MDA) in the spermatozoa obtained from asthenospermic male semen. Results An inverse correlation of MDA concentration with sperm motility is observed. Treatment of cells with L-arginine and vitamin E significantly decreases the MDA concentration and improves the sperm motility as compared to that in case of control samples. A combination of L-arginine and vitamin E shows synergistic effect on sperm motility and prevention of lipid peroxidation. Conclusion L-arginine and vitamin E protect the cells against the loss of sperm motility by lipid peroxidation. Therefore, supplementation of both L-arginine and vitamin E may improve sperm motility and increase the possibility of fertilization in asthenospermic subjects.http://www.ijfs.ir/article_45711_5652a5b8e1c7a4fbf75dd670c6b34c37.pdfasthenozoospermialipid-peroxidationvitamin el-argininehuman spermatozoa |
| spellingShingle | Sudha Srivastava Synergistic Protection of L-Arginine and Vitamin E On Lipid Peroxidation of Asthenospermic Patients International Journal of Fertility and Sterility asthenozoospermia lipid-peroxidation vitamin e l-arginine human spermatozoa |
| title | Synergistic Protection of L-Arginine and Vitamin E On Lipid Peroxidation of Asthenospermic Patients |
| title_full | Synergistic Protection of L-Arginine and Vitamin E On Lipid Peroxidation of Asthenospermic Patients |
| title_fullStr | Synergistic Protection of L-Arginine and Vitamin E On Lipid Peroxidation of Asthenospermic Patients |
| title_full_unstemmed | Synergistic Protection of L-Arginine and Vitamin E On Lipid Peroxidation of Asthenospermic Patients |
| title_short | Synergistic Protection of L-Arginine and Vitamin E On Lipid Peroxidation of Asthenospermic Patients |
| title_sort | synergistic protection of l arginine and vitamin e on lipid peroxidation of asthenospermic patients |
| topic | asthenozoospermia lipid-peroxidation vitamin e l-arginine human spermatozoa |
| url | http://www.ijfs.ir/article_45711_5652a5b8e1c7a4fbf75dd670c6b34c37.pdf |
| work_keys_str_mv | AT sudhasrivastava synergisticprotectionoflarginineandvitamineonlipidperoxidationofasthenospermicpatients |