Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4+ T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity

Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4+ T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity

Human immunodeficiency virus type 1 (HIV-1) infection causes a progressive depletion of CD4+ T cells. Despite its importance for HIV-1 pathogenesis, the precise mechanisms underlying CD4+ T-cell depletion remain incompletely understood. Here we make the surprising observation that antibody-dependent...

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Bibliographic Details
Main Authors: Jonathan Richard, Maxime Veillette, Shilei Ding, Daria Zoubchenok, Nirmin Alsahafi, Mathieu Coutu, Nathalie Brassard, Jongwoo Park, Joel R. Courter, Bruno Melillo, Amos B. Smith III, George M. Shaw, Beatrice H. Hahn, Joseph Sodroski, Daniel E. Kaufmann, Andrés Finzi
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:EBioMedicine
Subjects:
HIV-1
Envelope glycoproteins
gp120
CD4
CD4-bound conformation
Non-neutralizing antibodies
ADCC
CD4-mimetics
Bystander killing
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415302383

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