Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study
Malnutrition is a highly prevalent condition in older adults. It is associated with low muscle mass and function and increased occurrence of health problems. Maintaining an adequate nutritional status as well as a sufficient nutrient intake in older people is therefore essential to address this publ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/23/5182 |
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| author | Valérie Dormal Barbara Pachikian Elena Debock Marine Buchet Sylvie Copine Louise Deldicque |
| author_facet | Valérie Dormal Barbara Pachikian Elena Debock Marine Buchet Sylvie Copine Louise Deldicque |
| author_sort | Valérie Dormal |
| collection | DOAJ |
| description | Malnutrition is a highly prevalent condition in older adults. It is associated with low muscle mass and function and increased occurrence of health problems. Maintaining an adequate nutritional status as well as a sufficient nutrient intake in older people is therefore essential to address this public health problem. For this purpose, protein supplementation is known to prevent the loss of muscle mass during aging, and the consumption of various pomegranate extracts induces numerous health benefits, mainly through their antioxidant properties. However, to our knowledge, no study has to date investigated the impact of their combination on the level of malnutrition in older people. The objective of this preliminary study was thus to evaluate the safety of a combination of protein and a pomegranate extract in healthy subjects aged 65 years or more during a 21-day supplementation period. Thirty older participants were randomly assigned to receive protein and a pomegranate extract (Test group) or protein and maltodextrin (Control group) during a 21-day intervention period. The primary outcomes were the safety and tolerability of the supplementation defined as the occurrence of adverse events, and additional secondary outcomes included physical examination and hematological and biochemical parameters. No serious adverse events were reported in any group. Changes in physical, hematological, and biochemical parameters between the initial screening and the end of the study were equivalent in both groups, except for glutamate-pyruvate transaminase (GPT) and prealbumin, for which a decrease was observed only in the Test group. Our initial findings support the safety of the combination of protein and a pomegranate extract in healthy elderly people. Future clinical trials on a larger sample and a longer period are needed to determine the efficacy of this combination. |
| first_indexed | 2024-03-09T17:36:06Z |
| format | Article |
| id | doaj.art-cfaf3f7a440244859f3e2a9cd8ca6fc0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T17:36:06Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-cfaf3f7a440244859f3e2a9cd8ca6fc02023-11-24T11:53:30ZengMDPI AGNutrients2072-66432022-12-011423518210.3390/nu14235182Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety StudyValérie Dormal0Barbara Pachikian1Elena Debock2Marine Buchet3Sylvie Copine4Louise Deldicque5Center of Investigation in Clinical Nutrition, Université Catholique de Louvain, 1348 Louvain-la-Neuve, BelgiumCenter of Investigation in Clinical Nutrition, Université Catholique de Louvain, 1348 Louvain-la-Neuve, BelgiumCenter of Investigation in Clinical Nutrition, Université Catholique de Louvain, 1348 Louvain-la-Neuve, BelgiumCenter of Investigation in Clinical Nutrition, Université Catholique de Louvain, 1348 Louvain-la-Neuve, BelgiumCenter of Investigation in Clinical Nutrition, Université Catholique de Louvain, 1348 Louvain-la-Neuve, BelgiumCenter of Investigation in Clinical Nutrition, Université Catholique de Louvain, 1348 Louvain-la-Neuve, BelgiumMalnutrition is a highly prevalent condition in older adults. It is associated with low muscle mass and function and increased occurrence of health problems. Maintaining an adequate nutritional status as well as a sufficient nutrient intake in older people is therefore essential to address this public health problem. For this purpose, protein supplementation is known to prevent the loss of muscle mass during aging, and the consumption of various pomegranate extracts induces numerous health benefits, mainly through their antioxidant properties. However, to our knowledge, no study has to date investigated the impact of their combination on the level of malnutrition in older people. The objective of this preliminary study was thus to evaluate the safety of a combination of protein and a pomegranate extract in healthy subjects aged 65 years or more during a 21-day supplementation period. Thirty older participants were randomly assigned to receive protein and a pomegranate extract (Test group) or protein and maltodextrin (Control group) during a 21-day intervention period. The primary outcomes were the safety and tolerability of the supplementation defined as the occurrence of adverse events, and additional secondary outcomes included physical examination and hematological and biochemical parameters. No serious adverse events were reported in any group. Changes in physical, hematological, and biochemical parameters between the initial screening and the end of the study were equivalent in both groups, except for glutamate-pyruvate transaminase (GPT) and prealbumin, for which a decrease was observed only in the Test group. Our initial findings support the safety of the combination of protein and a pomegranate extract in healthy elderly people. Future clinical trials on a larger sample and a longer period are needed to determine the efficacy of this combination.https://www.mdpi.com/2072-6643/14/23/5182proteinpomegranate extractolder peoplesafetyclinical trial |
| spellingShingle | Valérie Dormal Barbara Pachikian Elena Debock Marine Buchet Sylvie Copine Louise Deldicque Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study Nutrients protein pomegranate extract older people safety clinical trial |
| title | Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study |
| title_full | Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study |
| title_fullStr | Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study |
| title_full_unstemmed | Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study |
| title_short | Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study |
| title_sort | evaluation of a dietary supplementation combining protein and a pomegranate extract in older people a safety study |
| topic | protein pomegranate extract older people safety clinical trial |
| url | https://www.mdpi.com/2072-6643/14/23/5182 |
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