Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report
Background. Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disease with an accumulation of mature B lymphocytes with fine reticular chromatin and cytoplasm with typical hairy-like cytoplasmic projections. Rarely, hairy cell leukemia manifests as a lung infiltration. The differentia...
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2023-12-01
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| Series: | Biomedical Papers |
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| Online Access: | https://biomed.papers.upol.cz/artkey/bio-202304-0013_pulmonary-damage-in-a-patient-with-hairy-cell-leukemia-infectious-involvement-or-hematological-disease-activi.php |
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| author | Dominika Ecsiova Katerina Kamaradova Marketa Nova Petr Hoffmann Petra Rozsivalova Martin Simkovic Pavel Zak |
| author_facet | Dominika Ecsiova Katerina Kamaradova Marketa Nova Petr Hoffmann Petra Rozsivalova Martin Simkovic Pavel Zak |
| author_sort | Dominika Ecsiova |
| collection | DOAJ |
| description | Background. Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disease with an accumulation of mature B lymphocytes with fine reticular chromatin and cytoplasm with typical hairy-like cytoplasmic projections. Rarely, hairy cell leukemia manifests as a lung infiltration. The differential diagnosis between infection and malignant involvement with hairy cell leukemia is often challenging in such situations.
Methods and Results. We present a 53-year-old female with an uncommon pulmonary involvement with hairy cell leukemia. In addition, we discuss the complicated differential diagnosis of pulmonary disease in patients with hairy cell leukemia and the treatment approach to these patients.
Conclusion. This case report describes the successful therapy management of a patient with pulmonary involvement by hairy cell leukemia. Therapy with interferon-alfa and cladribine resulted in long-term remission of the underlying disease. |
| first_indexed | 2024-03-09T01:04:07Z |
| format | Article |
| id | doaj.art-cfaf7cfecb9040e9a0b462dba6061a76 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-03-09T01:04:07Z |
| publishDate | 2023-12-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-cfaf7cfecb9040e9a0b462dba6061a762023-12-11T12:59:47ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212023-12-01167438538910.5507/bp.2022.026bio-202304-0013Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case reportDominika Ecsiova0Katerina Kamaradova1Marketa Nova2Petr Hoffmann3Petra Rozsivalova4Martin Simkovic5Pavel Zak64th Department of Internal Medicine - Haematology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital, Hradec Kralove, Czech RepublicThe Fingerland Department of Pathology, University Hospital Hradec Kralove, Czech RepublicThe Fingerland Department of Pathology, University Hospital Hradec Kralove, Czech RepublicDepartment of Radiology, University Hospital Hradec Kralove, Czech RepublicDepartment of Clinical Pharmacy, Hospital Pharmacy, University Hospital Hradec Kralove, Czech Republic4th Department of Internal Medicine - Haematology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital, Hradec Kralove, Czech Republic4th Department of Internal Medicine - Haematology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital, Hradec Kralove, Czech RepublicBackground. Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disease with an accumulation of mature B lymphocytes with fine reticular chromatin and cytoplasm with typical hairy-like cytoplasmic projections. Rarely, hairy cell leukemia manifests as a lung infiltration. The differential diagnosis between infection and malignant involvement with hairy cell leukemia is often challenging in such situations. Methods and Results. We present a 53-year-old female with an uncommon pulmonary involvement with hairy cell leukemia. In addition, we discuss the complicated differential diagnosis of pulmonary disease in patients with hairy cell leukemia and the treatment approach to these patients. Conclusion. This case report describes the successful therapy management of a patient with pulmonary involvement by hairy cell leukemia. Therapy with interferon-alfa and cladribine resulted in long-term remission of the underlying disease.https://biomed.papers.upol.cz/artkey/bio-202304-0013_pulmonary-damage-in-a-patient-with-hairy-cell-leukemia-infectious-involvement-or-hematological-disease-activi.phphairy cell leukemiapulmonary infiltrationinterferon-alfacladribine |
| spellingShingle | Dominika Ecsiova Katerina Kamaradova Marketa Nova Petr Hoffmann Petra Rozsivalova Martin Simkovic Pavel Zak Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report Biomedical Papers hairy cell leukemia pulmonary infiltration interferon-alfa cladribine |
| title | Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report |
| title_full | Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report |
| title_fullStr | Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report |
| title_full_unstemmed | Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report |
| title_short | Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report |
| title_sort | pulmonary damage in a patient with hairy cell leukemia infectious involvement or hematological disease activity case report |
| topic | hairy cell leukemia pulmonary infiltration interferon-alfa cladribine |
| url | https://biomed.papers.upol.cz/artkey/bio-202304-0013_pulmonary-damage-in-a-patient-with-hairy-cell-leukemia-infectious-involvement-or-hematological-disease-activi.php |
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