2-(5-Chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one derivatives as an antimicrobial agent
A series of 2-(5-chlorobenzo[d]thiazol-2-ylimino)-5-((3-(p-substituted phenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidin-4-ones (3a–h) were prepared from 2-(5-chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one (1) and 1-phenyl-3-(p-substituted phenyl)-1H-pyrazole-4-carbaldehyde (2a–h). All compo...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535212002444 |
| _version_ | 1818900971283021824 |
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| author | H. B′Bhatt S. Sharma |
| author_facet | H. B′Bhatt S. Sharma |
| author_sort | H. B′Bhatt |
| collection | DOAJ |
| description | A series of 2-(5-chlorobenzo[d]thiazol-2-ylimino)-5-((3-(p-substituted phenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidin-4-ones (3a–h) were prepared from 2-(5-chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one (1) and 1-phenyl-3-(p-substituted phenyl)-1H-pyrazole-4-carbaldehyde (2a–h). All compounds were characterized using elemental analytical (C, H, and N) and spectral (FT-IR, 1H NMR, 13C NMR and GC–MS) data. These compounds were screened for their antibacterial, antifungal and antimycobacterial activities. Antimicrobial activity was evaluated against the bacterial strains e.g., Eschericha coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus (MTCC 96), Streptococcus pyogenes (MTCC 442), H37Rv strain of Mycobacterium tuberculosis, and the antifungal activity was observed against strains e.g., Candida albicans (MTCC 227), Aspergillus niger (MTCC 282) and Aspergillus clavatus (MTCC 1323). All the synthesized compounds were found to possess moderate to excellent activity against selected strains. |
| first_indexed | 2024-12-19T20:12:20Z |
| format | Article |
| id | doaj.art-cfafa6f4c8ab4f01bff94ccd998cff01 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-19T20:12:20Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-cfafa6f4c8ab4f01bff94ccd998cff012022-12-21T20:07:17ZengElsevierArabian Journal of Chemistry1878-53522017-02-0110S1S531S53810.1016/j.arabjc.2012.10.0152-(5-Chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one derivatives as an antimicrobial agentH. B′BhattS. SharmaA series of 2-(5-chlorobenzo[d]thiazol-2-ylimino)-5-((3-(p-substituted phenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidin-4-ones (3a–h) were prepared from 2-(5-chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one (1) and 1-phenyl-3-(p-substituted phenyl)-1H-pyrazole-4-carbaldehyde (2a–h). All compounds were characterized using elemental analytical (C, H, and N) and spectral (FT-IR, 1H NMR, 13C NMR and GC–MS) data. These compounds were screened for their antibacterial, antifungal and antimycobacterial activities. Antimicrobial activity was evaluated against the bacterial strains e.g., Eschericha coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus (MTCC 96), Streptococcus pyogenes (MTCC 442), H37Rv strain of Mycobacterium tuberculosis, and the antifungal activity was observed against strains e.g., Candida albicans (MTCC 227), Aspergillus niger (MTCC 282) and Aspergillus clavatus (MTCC 1323). All the synthesized compounds were found to possess moderate to excellent activity against selected strains.http://www.sciencedirect.com/science/article/pii/S1878535212002444Knoevenagel condensation reactionAntibacterial activityAntifungal activityAntimycobacterial activity1-Phenyl-3-(p-substituted phenyl)-1H-pyrazole-4-carbaldehyde |
| spellingShingle | H. B′Bhatt S. Sharma 2-(5-Chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one derivatives as an antimicrobial agent Arabian Journal of Chemistry Knoevenagel condensation reaction Antibacterial activity Antifungal activity Antimycobacterial activity 1-Phenyl-3-(p-substituted phenyl)-1H-pyrazole-4-carbaldehyde |
| title | 2-(5-Chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one derivatives as an antimicrobial agent |
| title_full | 2-(5-Chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one derivatives as an antimicrobial agent |
| title_fullStr | 2-(5-Chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one derivatives as an antimicrobial agent |
| title_full_unstemmed | 2-(5-Chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one derivatives as an antimicrobial agent |
| title_short | 2-(5-Chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one derivatives as an antimicrobial agent |
| title_sort | 2 5 chlorobenzo d thiazol 2 ylimino thiazolidin 4 one derivatives as an antimicrobial agent |
| topic | Knoevenagel condensation reaction Antibacterial activity Antifungal activity Antimycobacterial activity 1-Phenyl-3-(p-substituted phenyl)-1H-pyrazole-4-carbaldehyde |
| url | http://www.sciencedirect.com/science/article/pii/S1878535212002444 |
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