Estimating the impact of pneumococcal conjugate vaccines on childhood pneumonia in sub-Saharan Africa: A systematic review [version 2; peer review: 2 approved]
Background: This study aimed to summarise the evidence on the impact of routine administration of 10-valent and 13-valent pneumococcal conjugate vaccines on pneumonia in children under five years of age in sub-Saharan Africa. Methods: A systematic search of the literature was conducted including pri...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2020-11-01
|
| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/9-765/v2 |
| _version_ | 1818435670648029184 |
|---|---|
| author | Chukwuemeka Onwuchekwa Bassey Edem Victor Williams Emmanuel Oga |
| author_facet | Chukwuemeka Onwuchekwa Bassey Edem Victor Williams Emmanuel Oga |
| author_sort | Chukwuemeka Onwuchekwa |
| collection | DOAJ |
| description | Background: This study aimed to summarise the evidence on the impact of routine administration of 10-valent and 13-valent pneumococcal conjugate vaccines on pneumonia in children under five years of age in sub-Saharan Africa. Methods: A systematic search of the literature was conducted including primary research reporting on the impact of 10- or 13-valent pneumococcal vaccines on childhood pneumonia in a sub-Saharan African country. Case-control, cohort, pre-post and time-series study designs were eligible for inclusion. Thematic narrative synthesis was carried out to summarise the findings. Results: Eight records were included in the final analysis, 6 records were pre-post or time-series studies, 1 was a case-control study and 1 report combined pre-post and case-control studies. Vaccine impact on clinical pneumonia measured as percentage reduction in risk (%RR) was mostly non-significant. The reduction in risk was more consistent in radiological and pneumococcal pneumonia. Conclusions: Evidence of the positive impact of routine infant pneumococcal vaccination on clinical pneumonia incidence in sub-Saharan Africa is inconclusive. Ongoing surveillance and further research is required to establish the long term trend in pneumonia epidemiology and aetiology after PCV introduction. PROSPERO registration: CRD42019142369 30/09/19 |
| first_indexed | 2024-12-14T16:56:35Z |
| format | Article |
| id | doaj.art-cfb0cf492dd144e0ae21ca4debcc5aba |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-14T16:56:35Z |
| publishDate | 2020-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-cfb0cf492dd144e0ae21ca4debcc5aba2022-12-21T22:53:57ZengF1000 Research LtdF1000Research2046-14022020-11-01910.12688/f1000research.25227.230623Estimating the impact of pneumococcal conjugate vaccines on childhood pneumonia in sub-Saharan Africa: A systematic review [version 2; peer review: 2 approved]Chukwuemeka Onwuchekwa0Bassey Edem1Victor Williams2Emmanuel Oga3Institute of Tropical Medicine, Antwerp, Antwerp, 2000, BelgiumMedical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Serekunda, The GambiaSchool of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaResearch Triangle Institue (RTI) International, 6110 Executive Boulevard, Rockville, USABackground: This study aimed to summarise the evidence on the impact of routine administration of 10-valent and 13-valent pneumococcal conjugate vaccines on pneumonia in children under five years of age in sub-Saharan Africa. Methods: A systematic search of the literature was conducted including primary research reporting on the impact of 10- or 13-valent pneumococcal vaccines on childhood pneumonia in a sub-Saharan African country. Case-control, cohort, pre-post and time-series study designs were eligible for inclusion. Thematic narrative synthesis was carried out to summarise the findings. Results: Eight records were included in the final analysis, 6 records were pre-post or time-series studies, 1 was a case-control study and 1 report combined pre-post and case-control studies. Vaccine impact on clinical pneumonia measured as percentage reduction in risk (%RR) was mostly non-significant. The reduction in risk was more consistent in radiological and pneumococcal pneumonia. Conclusions: Evidence of the positive impact of routine infant pneumococcal vaccination on clinical pneumonia incidence in sub-Saharan Africa is inconclusive. Ongoing surveillance and further research is required to establish the long term trend in pneumonia epidemiology and aetiology after PCV introduction. PROSPERO registration: CRD42019142369 30/09/19https://f1000research.com/articles/9-765/v2 |
| spellingShingle | Chukwuemeka Onwuchekwa Bassey Edem Victor Williams Emmanuel Oga Estimating the impact of pneumococcal conjugate vaccines on childhood pneumonia in sub-Saharan Africa: A systematic review [version 2; peer review: 2 approved] F1000Research |
| title | Estimating the impact of pneumococcal conjugate vaccines on childhood pneumonia in sub-Saharan Africa: A systematic review [version 2; peer review: 2 approved] |
| title_full | Estimating the impact of pneumococcal conjugate vaccines on childhood pneumonia in sub-Saharan Africa: A systematic review [version 2; peer review: 2 approved] |
| title_fullStr | Estimating the impact of pneumococcal conjugate vaccines on childhood pneumonia in sub-Saharan Africa: A systematic review [version 2; peer review: 2 approved] |
| title_full_unstemmed | Estimating the impact of pneumococcal conjugate vaccines on childhood pneumonia in sub-Saharan Africa: A systematic review [version 2; peer review: 2 approved] |
| title_short | Estimating the impact of pneumococcal conjugate vaccines on childhood pneumonia in sub-Saharan Africa: A systematic review [version 2; peer review: 2 approved] |
| title_sort | estimating the impact of pneumococcal conjugate vaccines on childhood pneumonia in sub saharan africa a systematic review version 2 peer review 2 approved |
| url | https://f1000research.com/articles/9-765/v2 |
| work_keys_str_mv | AT chukwuemekaonwuchekwa estimatingtheimpactofpneumococcalconjugatevaccinesonchildhoodpneumoniainsubsaharanafricaasystematicreviewversion2peerreview2approved AT basseyedem estimatingtheimpactofpneumococcalconjugatevaccinesonchildhoodpneumoniainsubsaharanafricaasystematicreviewversion2peerreview2approved AT victorwilliams estimatingtheimpactofpneumococcalconjugatevaccinesonchildhoodpneumoniainsubsaharanafricaasystematicreviewversion2peerreview2approved AT emmanueloga estimatingtheimpactofpneumococcalconjugatevaccinesonchildhoodpneumoniainsubsaharanafricaasystematicreviewversion2peerreview2approved |