NACA and LRP6 Are Part of a Common Genetic Pathway Necessary for Full Anabolic Response to Intermittent PTH

NACA and LRP6 Are Part of a Common Genetic Pathway Necessary for Full Anabolic Response to Intermittent PTH

PTH induces phosphorylation of the transcriptional coregulator NACA on serine 99 through Gαs and PKA. This leads to nuclear translocation of NACA and expression of the target gene <i>Lrp6</i>, encoding a coreceptor of the PTH receptor (PTH1R) necessary for full anabolic response to inter...

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Bibliographic Details
Main Authors: René St-Arnaud, Martin Pellicelli, Mahmoud Ismail, Alice Arabian, Toghrul Jafarov, Chengji J. Zhou
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
NACA
LRP6
parathyroid hormone
osteoblasts
osteocytes
bone
Online Access:https://www.mdpi.com/1422-0067/23/2/940

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