Rhinoviruses as critical agents in severe bronchiolitis in infants
Objectives: To detect RSV or other thirteen respiratory viruses as possible causer agent of bronchiolitis in infants. Method: This is an epidemiological analytical study, conducted using a nasopharyngeal aspirate of 173 hospitalized children younger than two years old with severe bronchiolitis in th...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Jornal de Pediatria |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0021755721001674 |
| _version_ | 1828312931426631680 |
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| author | Juliana Cristina Santiago Bastos Paulo Vitor Marques Simas Leonardo Cardia Caserta Alfonso Eduardo Alvarez Bragunde Fernando Augusto de Lima Marson Matheus Cavalheiro Martini Marina Aiello Padilla José Dirceu Ribeiro Márcia Mercês Aparecida Bianchi dos Santos Clarice Weis Arns |
| author_facet | Juliana Cristina Santiago Bastos Paulo Vitor Marques Simas Leonardo Cardia Caserta Alfonso Eduardo Alvarez Bragunde Fernando Augusto de Lima Marson Matheus Cavalheiro Martini Marina Aiello Padilla José Dirceu Ribeiro Márcia Mercês Aparecida Bianchi dos Santos Clarice Weis Arns |
| author_sort | Juliana Cristina Santiago Bastos |
| collection | DOAJ |
| description | Objectives: To detect RSV or other thirteen respiratory viruses as possible causer agent of bronchiolitis in infants. Method: This is an epidemiological analytical study, conducted using a nasopharyngeal aspirate of 173 hospitalized children younger than two years old with severe bronchiolitis in three hospitals in the Campinas Metropolitan Region (CMR) during 2013-14. The data was statically evaluated by Pearson's chi-squared test with statistical significance of 0.05 and 95% confidence level. Results: As expected, the most prevalent viruses detected were RSV A and B in 47% and 16% of the samples, respectively. However, almost a third of severe bronchiolitis cases there were no detection of RSV, and the viruses more commonly detected were rhinoviruses, which were identified in almost a quarter of all positive samples for at least a viral agent. Conclusions: Although nothing could be concluded from the disease severity and clinical-epidemiological data, the present study's results indicate that severe bronchiolitis is not always related to RSV infections in children younger than two years old, and the rhinoviruses were more prevalent in these cases. These findings reinforce the need to carry out a viral diagnosis in the hospital emergency would be very appropriate for all cases of respiratory infections in children, even for diseases in which the primary etiological agent seems to be well known. |
| first_indexed | 2024-04-13T16:23:25Z |
| format | Article |
| id | doaj.art-cfb2aadd4f67429fb76c2cdf1945f1ed |
| institution | Directory Open Access Journal |
| issn | 0021-7557 |
| language | English |
| last_indexed | 2024-04-13T16:23:25Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj.art-cfb2aadd4f67429fb76c2cdf1945f1ed2022-12-22T02:39:50ZengElsevierJornal de Pediatria0021-75572022-07-01984362368Rhinoviruses as critical agents in severe bronchiolitis in infantsJuliana Cristina Santiago Bastos0Paulo Vitor Marques Simas1Leonardo Cardia Caserta2Alfonso Eduardo Alvarez Bragunde3Fernando Augusto de Lima Marson4Matheus Cavalheiro Martini5Marina Aiello Padilla6José Dirceu Ribeiro7Márcia Mercês Aparecida Bianchi dos Santos8Clarice Weis Arns9Universidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, BrazilUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, Brazil; The National University of San Marcos, Veterinary School, Laboratory of Avian Pathology, Lima, PeruUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, Brazil; Cornell University, College of Veterinary Medicine, Department of Population Medicine and Diagnostic Sciences, Ithaca, United StatesUniversidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrazilUniversidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrazilUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, BrazilUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, BrazilUniversidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrazilUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, BrazilUniversidade Estadual de Campinas (UNICAMP), Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Laboratório de Virologia Animal, Campinas, SP, Brazil; Corresponding author.Objectives: To detect RSV or other thirteen respiratory viruses as possible causer agent of bronchiolitis in infants. Method: This is an epidemiological analytical study, conducted using a nasopharyngeal aspirate of 173 hospitalized children younger than two years old with severe bronchiolitis in three hospitals in the Campinas Metropolitan Region (CMR) during 2013-14. The data was statically evaluated by Pearson's chi-squared test with statistical significance of 0.05 and 95% confidence level. Results: As expected, the most prevalent viruses detected were RSV A and B in 47% and 16% of the samples, respectively. However, almost a third of severe bronchiolitis cases there were no detection of RSV, and the viruses more commonly detected were rhinoviruses, which were identified in almost a quarter of all positive samples for at least a viral agent. Conclusions: Although nothing could be concluded from the disease severity and clinical-epidemiological data, the present study's results indicate that severe bronchiolitis is not always related to RSV infections in children younger than two years old, and the rhinoviruses were more prevalent in these cases. These findings reinforce the need to carry out a viral diagnosis in the hospital emergency would be very appropriate for all cases of respiratory infections in children, even for diseases in which the primary etiological agent seems to be well known.http://www.sciencedirect.com/science/article/pii/S0021755721001674BronchiolitisEpidemiologyRespiratory syncytial virusRhinovirus |
| spellingShingle | Juliana Cristina Santiago Bastos Paulo Vitor Marques Simas Leonardo Cardia Caserta Alfonso Eduardo Alvarez Bragunde Fernando Augusto de Lima Marson Matheus Cavalheiro Martini Marina Aiello Padilla José Dirceu Ribeiro Márcia Mercês Aparecida Bianchi dos Santos Clarice Weis Arns Rhinoviruses as critical agents in severe bronchiolitis in infants Jornal de Pediatria Bronchiolitis Epidemiology Respiratory syncytial virus Rhinovirus |
| title | Rhinoviruses as critical agents in severe bronchiolitis in infants |
| title_full | Rhinoviruses as critical agents in severe bronchiolitis in infants |
| title_fullStr | Rhinoviruses as critical agents in severe bronchiolitis in infants |
| title_full_unstemmed | Rhinoviruses as critical agents in severe bronchiolitis in infants |
| title_short | Rhinoviruses as critical agents in severe bronchiolitis in infants |
| title_sort | rhinoviruses as critical agents in severe bronchiolitis in infants |
| topic | Bronchiolitis Epidemiology Respiratory syncytial virus Rhinovirus |
| url | http://www.sciencedirect.com/science/article/pii/S0021755721001674 |
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