The Expressions of Cancer Stem Cell Markers and Nonclassical HLA antigens in Breast Tumors
Objective: There is a strong relationship between the cancer stem cells (CSCs) and poor prognosis, metastasis and recurrence. In addition to this CSCs are resistant to chemotherapy and radiotherapy. Therefore, current treatment approaches may be ineffective to elimination of CSCs. The tumor cells ha...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2017-09-01
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| Series: | İstanbul Medical Journal |
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http://imj.galenos.com.tr/archives/archive-detail/article-preview/the-expressions-of-cancer-stem-cell-markers-and-no/20486
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| _version_ | 1797916388606607360 |
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| author | Rabia Bilge Özgül Özdemir Alper Tunga Özdemir Fatih Oltulu Kamile Kurt Gürkan Yiğittürk Cengiz Kırmaz |
| author_facet | Rabia Bilge Özgül Özdemir Alper Tunga Özdemir Fatih Oltulu Kamile Kurt Gürkan Yiğittürk Cengiz Kırmaz |
| author_sort | Rabia Bilge Özgül Özdemir |
| collection | DOAJ |
| description | Objective: There is a strong relationship between the cancer stem cells (CSCs) and poor prognosis, metastasis and recurrence. In addition to this CSCs are resistant to chemotherapy and radiotherapy. Therefore, current treatment approaches may be ineffective to elimination of CSCs. The tumor cells have various adaptations for escaping from immune cells. The human leukocyte antigen (HLA) -G, which expressions restricted with fetal tissues and HLA-E are kind of tumor immune evasive adaptations. In this study, we aimed to investigate the relationship between the CSCs and immune evasive adaptations of breast tumors.Methods: We immunohistochemically evaluated that the expressions of cluster of differentiation (CD) 44, CD133, Homeobox protein Nanog, octamerbinding transcription factor (Oct) 3/4, HLA-G and HLA-E in the advanced stage breast cancer tissues (n=10) and the non-malignant breast biopsies (n=10).Results: We detected that the significantly increased expressions of especially Nanog (p<0.001) and also CD44 (p<0.001), CD133 (p<0.001) and Oct3/4 (p<0.001) in the advanced stage breast tumor group compared with non-malignant breast biopsies group, but the HLA-G (p<0.001) and HLA-E (p<0.001) decreased.Conclusion: These findings suggested that, malignant breast tumors may have CSC-like cells, and these cells may play role for occurring malignant behavior. To proliferation and tumor formation, the immune evasion is essential for both of malignant and benign tumors. Higher expressions of HLA-G and HLA-E may be an indication that the nonmalign tumors more immune evasive than the malign tumors. However, further prospective studies are needed to confirm our findings. |
| first_indexed | 2024-04-10T12:56:24Z |
| format | Article |
| id | doaj.art-cfb6734989e1415a84ac567a1d98994d |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T12:56:24Z |
| publishDate | 2017-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-cfb6734989e1415a84ac567a1d98994d2023-02-15T16:13:29ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2017-09-0118312813410.5152/imj.2017.6349713049054The Expressions of Cancer Stem Cell Markers and Nonclassical HLA antigens in Breast TumorsRabia Bilge Özgül Özdemir0Alper Tunga Özdemir1Fatih Oltulu2Kamile Kurt3Gürkan Yiğittürk4Cengiz Kırmaz5 Manisa State Hospital, Immunology And Allergy Clinic, Manisa, Turkey Department Of Stem Cell, Ege University Health Sciences Institute, İzmir, Turkey Department of Histology And Embryology, Ege University School of Medicine, İzmir, Turkey Merkezefendi State Hospital, Pathology Laboratory, Manisa, Turkey Department of Histology And Embryology, Ege University School of Medicine, İzmir, Turkey Department of Immunology And Allergy, Manisa Celal Bayar University School of Medicine, Manisa, Turkey Objective: There is a strong relationship between the cancer stem cells (CSCs) and poor prognosis, metastasis and recurrence. In addition to this CSCs are resistant to chemotherapy and radiotherapy. Therefore, current treatment approaches may be ineffective to elimination of CSCs. The tumor cells have various adaptations for escaping from immune cells. The human leukocyte antigen (HLA) -G, which expressions restricted with fetal tissues and HLA-E are kind of tumor immune evasive adaptations. In this study, we aimed to investigate the relationship between the CSCs and immune evasive adaptations of breast tumors.Methods: We immunohistochemically evaluated that the expressions of cluster of differentiation (CD) 44, CD133, Homeobox protein Nanog, octamerbinding transcription factor (Oct) 3/4, HLA-G and HLA-E in the advanced stage breast cancer tissues (n=10) and the non-malignant breast biopsies (n=10).Results: We detected that the significantly increased expressions of especially Nanog (p<0.001) and also CD44 (p<0.001), CD133 (p<0.001) and Oct3/4 (p<0.001) in the advanced stage breast tumor group compared with non-malignant breast biopsies group, but the HLA-G (p<0.001) and HLA-E (p<0.001) decreased.Conclusion: These findings suggested that, malignant breast tumors may have CSC-like cells, and these cells may play role for occurring malignant behavior. To proliferation and tumor formation, the immune evasion is essential for both of malignant and benign tumors. Higher expressions of HLA-G and HLA-E may be an indication that the nonmalign tumors more immune evasive than the malign tumors. However, further prospective studies are needed to confirm our findings. http://imj.galenos.com.tr/archives/archive-detail/article-preview/the-expressions-of-cancer-stem-cell-markers-and-no/20486 Breast tumorcancer stem cellhuman leukocyte antigen Ghuman leukocyte antigen Etumor immune evasion |
| spellingShingle | Rabia Bilge Özgül Özdemir Alper Tunga Özdemir Fatih Oltulu Kamile Kurt Gürkan Yiğittürk Cengiz Kırmaz The Expressions of Cancer Stem Cell Markers and Nonclassical HLA antigens in Breast Tumors İstanbul Medical Journal Breast tumor cancer stem cell human leukocyte antigen G human leukocyte antigen E tumor immune evasion |
| title | The Expressions of Cancer Stem Cell Markers and Nonclassical HLA antigens in Breast Tumors |
| title_full | The Expressions of Cancer Stem Cell Markers and Nonclassical HLA antigens in Breast Tumors |
| title_fullStr | The Expressions of Cancer Stem Cell Markers and Nonclassical HLA antigens in Breast Tumors |
| title_full_unstemmed | The Expressions of Cancer Stem Cell Markers and Nonclassical HLA antigens in Breast Tumors |
| title_short | The Expressions of Cancer Stem Cell Markers and Nonclassical HLA antigens in Breast Tumors |
| title_sort | expressions of cancer stem cell markers and nonclassical hla antigens in breast tumors |
| topic | Breast tumor cancer stem cell human leukocyte antigen G human leukocyte antigen E tumor immune evasion |
| url |
http://imj.galenos.com.tr/archives/archive-detail/article-preview/the-expressions-of-cancer-stem-cell-markers-and-no/20486
|
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