ERK mediates interferon gamma-induced melanoma cell death

ERK mediates interferon gamma-induced melanoma cell death

Abstract Background Interferon-gamma (IFNγ) exerts potent growth inhibitory effects on a wide range of cancer cells through unknown signaling pathways. We pursued complementary screening approaches to characterize the growth inhibition pathway. Methods We performed chemical genomics and whole genome...

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Bibliographic Details
Main Authors:	Ameya Champhekar, Rachel Heymans, Justin Saco, Guillem Turon Font, Cynthia Gonzalez, Anne Gao, John Pham, June Lee, Ryan Maryoung, Egmidio Medina, Katie M. Campbell, Daniel Karin, David Austin, Robert Damioseaux, Antoni Ribas
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Series:	Molecular Cancer
Subjects:	IFNγ ERK signaling Tumor growth inhibition Stress response Melanoma
Online Access:	https://doi.org/10.1186/s12943-023-01868-x

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