Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases
BACKGROUND: Monoclonal B-cell lymphocytosis is classified as 'high-count or clinical' monoclonal B-cell lymphocytosis and 'low-count or population' monoclonal B-cell lymphocytosis. Previously, 167 first-degree relatives pertaining to sporadic (non-familial) chronic lymphocytic le...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-10-01
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| Series: | Revista Brasileira de Hematologia e Hemoterapia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842015000500292&lng=en&tlng=en |
| _version_ | 1828168833531117568 |
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| author | Daniel Mazza Matos Felipe Magalhães Furtado Roberto Passetto Falcão |
| author_facet | Daniel Mazza Matos Felipe Magalhães Furtado Roberto Passetto Falcão |
| author_sort | Daniel Mazza Matos |
| collection | DOAJ |
| description | BACKGROUND: Monoclonal B-cell lymphocytosis is classified as 'high-count or clinical' monoclonal B-cell lymphocytosis and 'low-count or population' monoclonal B-cell lymphocytosis. Previously, 167 first-degree relatives pertaining to sporadic (non-familial) chronic lymphocytic leukemia families were studied and the presence of seven monoclonal B-cell lymphocytosis individuals was reported.OBJECTIVE: The aim of this report is to describe the outcomes of five of the original monoclonal B-cell lymphocytosis individuals.METHODS: Flow cytometry analysis was performed on mononuclear cells previously isolated from peripheral blood samples. A strategy of sequential gating designed to identify the population of CD19+/CD5+ B-lymphocytes was used and, subsequently, the monoclonal B-cell lymphocytosis cells were characterized by the CD20weak/CD79bweak/negative phenotype.RESULTS: The monoclonal B-cell lymphocytosis clone showed consistent stability over time with little variations in size. After a median follow-up of 7.6 years, none of the five monoclonal B-cell lymphocytosis individuals progressed to chronic lymphocytic leukemia or other B-cell lymphoproliferative disease.CONCLUSIONS: The data of this study suggest that chronic lymphocytic leukemia-like monoclonal B-cell lymphocytosis detected in the context of sporadic chronic lymphocytic leukemia families is not prone to clinical evolution and could be just a sign of immune senescence. |
| first_indexed | 2024-04-12T02:41:20Z |
| format | Article |
| id | doaj.art-cfb74811735e48859eebf9797fc69d7b |
| institution | Directory Open Access Journal |
| issn | 1806-0870 |
| language | English |
| last_indexed | 2024-04-12T02:41:20Z |
| publishDate | 2015-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Brasileira de Hematologia e Hemoterapia |
| spelling | doaj.art-cfb74811735e48859eebf9797fc69d7b2022-12-22T03:51:19ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1806-08702015-10-0137529229510.1016/j.bjhh.2015.05.006S1516-84842015000500292Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseasesDaniel Mazza MatosFelipe Magalhães FurtadoRoberto Passetto FalcãoBACKGROUND: Monoclonal B-cell lymphocytosis is classified as 'high-count or clinical' monoclonal B-cell lymphocytosis and 'low-count or population' monoclonal B-cell lymphocytosis. Previously, 167 first-degree relatives pertaining to sporadic (non-familial) chronic lymphocytic leukemia families were studied and the presence of seven monoclonal B-cell lymphocytosis individuals was reported.OBJECTIVE: The aim of this report is to describe the outcomes of five of the original monoclonal B-cell lymphocytosis individuals.METHODS: Flow cytometry analysis was performed on mononuclear cells previously isolated from peripheral blood samples. A strategy of sequential gating designed to identify the population of CD19+/CD5+ B-lymphocytes was used and, subsequently, the monoclonal B-cell lymphocytosis cells were characterized by the CD20weak/CD79bweak/negative phenotype.RESULTS: The monoclonal B-cell lymphocytosis clone showed consistent stability over time with little variations in size. After a median follow-up of 7.6 years, none of the five monoclonal B-cell lymphocytosis individuals progressed to chronic lymphocytic leukemia or other B-cell lymphoproliferative disease.CONCLUSIONS: The data of this study suggest that chronic lymphocytic leukemia-like monoclonal B-cell lymphocytosis detected in the context of sporadic chronic lymphocytic leukemia families is not prone to clinical evolution and could be just a sign of immune senescence.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842015000500292&lng=en&tlng=enMonoclonal B-cell lymphocytosisChronic lymphocytic leukemiaFlow cytometryB cellsFirst-degree relatives |
| spellingShingle | Daniel Mazza Matos Felipe Magalhães Furtado Roberto Passetto Falcão Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases Revista Brasileira de Hematologia e Hemoterapia Monoclonal B-cell lymphocytosis Chronic lymphocytic leukemia Flow cytometry B cells First-degree relatives |
| title | Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases |
| title_full | Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases |
| title_fullStr | Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases |
| title_full_unstemmed | Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases |
| title_short | Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases |
| title_sort | monoclonal b cell lymphocytosis in individuals from sporadic non familial chronic lymphocytic leukemia families persists over time but does not progress to chronic b cell lymphoproliferative diseases |
| topic | Monoclonal B-cell lymphocytosis Chronic lymphocytic leukemia Flow cytometry B cells First-degree relatives |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842015000500292&lng=en&tlng=en |
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