Nucleolus and centromere Tyramide Signal Amplification-Seq reveals variable localization of heterochromatin in different cell types

Nucleolus and centromere Tyramide Signal Amplification-Seq reveals variable localization of heterochromatin in different cell types

Abstract Genome differential positioning within interphase nuclei remains poorly explored. We extended and validated Tyramide Signal Amplification (TSA)-seq to map genomic regions near nucleoli and pericentric heterochromatin in four human cell lines. Our study confirmed that smaller chromosomes loc...

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Bibliographic Details
Main Authors: Pradeep Kumar, Omid Gholamalamdari, Yang Zhang, Liguo Zhang, Anastassiia Vertii, Tom van Schaik, Daan Peric-Hupkes, Takayo Sasaki, David M. Gilbert, Bas van Steensel, Jian Ma, Paul D. Kaufman, Andrew S. Belmont
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06838-7

Internet

https://doi.org/10.1038/s42003-024-06838-7

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