Predictive Factors for Local Recurrence after Intraoperative Microwave Ablation for Colorectal Liver Metastases
This study aimed to clarify local recurrence (LR) predictive factors following intraoperative microwave ablation (MWA) for colorectal liver metastases. The data from 195 patients with 1392 CRLM lesions, who were preoperatively diagnosed by gadolinium-enhanced MRI with diffusion-weighted imaging and...
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MDPI AG
2022-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/1/122 |
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| author | Yoshiyuki Wada Yuko Takami Tomoki Ryu Yoshihiro Uchino Tota Kugiyama Yoriko Nomura Hideki Saitsu |
| author_facet | Yoshiyuki Wada Yuko Takami Tomoki Ryu Yoshihiro Uchino Tota Kugiyama Yoriko Nomura Hideki Saitsu |
| author_sort | Yoshiyuki Wada |
| collection | DOAJ |
| description | This study aimed to clarify local recurrence (LR) predictive factors following intraoperative microwave ablation (MWA) for colorectal liver metastases. The data from 195 patients with 1392 CRLM lesions, who were preoperatively diagnosed by gadolinium-enhanced MRI with diffusion-weighted imaging and dynamic CT and treated with intraoperative MWA (2450 MHz) with or without hepatectomy, from January 2005 to December 2019, were retrospectively reviewed and analyzed using logistic regression. In addition, the margins were measured on contrast-enhanced CT 6 weeks post-ablation. Overall, 1066 lesions were ablated. The LRs occurred in 44 lesions (4.1%) among 39 patients (20.0%). The multivariate analysis per patient showed that tumor size > 20 mm and ablation margin < 5 mm were significant predictors for LR. Furthermore, multivariate analysis per lesion revealed that segments 1, 7, and 8 and tumor size > 15 mm, ablation margin < 5 mm, tumor size > 20 mm, and proximity to the Glisson were significant LR predictors. Finally, the outcome of this study may help determine indications for MWA. |
| first_indexed | 2024-03-11T10:07:16Z |
| format | Article |
| id | doaj.art-cfb98bf2279a45b99b64dd6b5b15a033 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T10:07:16Z |
| publishDate | 2022-12-01 |
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| record_format | Article |
| series | Cancers |
| spelling | doaj.art-cfb98bf2279a45b99b64dd6b5b15a0332023-11-16T15:01:55ZengMDPI AGCancers2072-66942022-12-0115112210.3390/cancers15010122Predictive Factors for Local Recurrence after Intraoperative Microwave Ablation for Colorectal Liver MetastasesYoshiyuki Wada0Yuko Takami1Tomoki Ryu2Yoshihiro Uchino3Tota Kugiyama4Yoriko Nomura5Hideki Saitsu6Department of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, JapanDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, JapanDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, JapanDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, JapanDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, JapanDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, JapanDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, JapanThis study aimed to clarify local recurrence (LR) predictive factors following intraoperative microwave ablation (MWA) for colorectal liver metastases. The data from 195 patients with 1392 CRLM lesions, who were preoperatively diagnosed by gadolinium-enhanced MRI with diffusion-weighted imaging and dynamic CT and treated with intraoperative MWA (2450 MHz) with or without hepatectomy, from January 2005 to December 2019, were retrospectively reviewed and analyzed using logistic regression. In addition, the margins were measured on contrast-enhanced CT 6 weeks post-ablation. Overall, 1066 lesions were ablated. The LRs occurred in 44 lesions (4.1%) among 39 patients (20.0%). The multivariate analysis per patient showed that tumor size > 20 mm and ablation margin < 5 mm were significant predictors for LR. Furthermore, multivariate analysis per lesion revealed that segments 1, 7, and 8 and tumor size > 15 mm, ablation margin < 5 mm, tumor size > 20 mm, and proximity to the Glisson were significant LR predictors. Finally, the outcome of this study may help determine indications for MWA.https://www.mdpi.com/2072-6694/15/1/122microwaveablationlocal recurrenceliver metastasespredictive factors |
| spellingShingle | Yoshiyuki Wada Yuko Takami Tomoki Ryu Yoshihiro Uchino Tota Kugiyama Yoriko Nomura Hideki Saitsu Predictive Factors for Local Recurrence after Intraoperative Microwave Ablation for Colorectal Liver Metastases Cancers microwave ablation local recurrence liver metastases predictive factors |
| title | Predictive Factors for Local Recurrence after Intraoperative Microwave Ablation for Colorectal Liver Metastases |
| title_full | Predictive Factors for Local Recurrence after Intraoperative Microwave Ablation for Colorectal Liver Metastases |
| title_fullStr | Predictive Factors for Local Recurrence after Intraoperative Microwave Ablation for Colorectal Liver Metastases |
| title_full_unstemmed | Predictive Factors for Local Recurrence after Intraoperative Microwave Ablation for Colorectal Liver Metastases |
| title_short | Predictive Factors for Local Recurrence after Intraoperative Microwave Ablation for Colorectal Liver Metastases |
| title_sort | predictive factors for local recurrence after intraoperative microwave ablation for colorectal liver metastases |
| topic | microwave ablation local recurrence liver metastases predictive factors |
| url | https://www.mdpi.com/2072-6694/15/1/122 |
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