hUCMSCs reduce theca interstitial cells apoptosis and restore ovarian function in premature ovarian insufficiency rats through regulating NR4A1-mediated mitochondrial mechanisms

hUCMSCs reduce theca interstitial cells apoptosis and restore ovarian function in premature ovarian insufficiency rats through regulating NR4A1-mediated mitochondrial mechanisms

Abstract Background Human umbilical cord mesenchymal stem cells (hUCMSCs, retrospectively registered) have a lot of promise for treating theca interstitial cells(TICs) dysfunction in premature ovarian insufficiency (POI). The mechanisms, however, are still unknown. Methods To examine the therapeutic...

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Bibliographic Details
Main Authors: Qianqian Luo, Yu Tang, Zhonglin Jiang, Hongchu Bao, Qiang Fu, Hongqin Zhang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Reproductive Biology and Endocrinology
Subjects:
Premature ovarian insufficiency
hUCMSCs
Theca interstitial cells
NR4A1
Mitochondria
Online Access:https://doi.org/10.1186/s12958-022-00992-5

Internet

https://doi.org/10.1186/s12958-022-00992-5

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