Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia
Aim. To evaluate the efficiency of the original ALL-MB-2002 protocol within the multicenter study of treatment of acute lymphoblastic leukemia (ALL) in children. Subjects and methods. A total of 1873 primary patients with ALL aged 1 to 18 years, of whom 1544 patients were enrolled in this study, wer...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2010-07-01
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| Series: | Терапевтический архив |
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| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30592 |
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| author | Yu V Rumyantseva A I Karachunsky O V Aleinikova L G Fechina A V Shamardina D V Litvinov N I Ponomareva E G Boichenko S A Dudkin O V Streneva K L Kondratchik E G Mansurova L M Minkina E S Lapotentova E V Inyushkina N B Yudina G P Pavlova E V Zhukovskaya O P Khlebnikova S N Lagoiko E V Basharova R E Denisov V D Zlobina E S Banshchikova K S Aslanyan E V Kondakova E V Tselousova N V Myakova T V Turobova O V Ryskal N F Chipsanova S R Varfolomeyeva A G Rumyantsev |
| author_facet | Yu V Rumyantseva A I Karachunsky O V Aleinikova L G Fechina A V Shamardina D V Litvinov N I Ponomareva E G Boichenko S A Dudkin O V Streneva K L Kondratchik E G Mansurova L M Minkina E S Lapotentova E V Inyushkina N B Yudina G P Pavlova E V Zhukovskaya O P Khlebnikova S N Lagoiko E V Basharova R E Denisov V D Zlobina E S Banshchikova K S Aslanyan E V Kondakova E V Tselousova N V Myakova T V Turobova O V Ryskal N F Chipsanova S R Varfolomeyeva A G Rumyantsev |
| author_sort | Yu V Rumyantseva |
| collection | DOAJ |
| description | Aim. To evaluate the efficiency of the original ALL-MB-2002 protocol within the multicenter study of treatment of acute lymphoblastic leukemia (ALL) in children.
Subjects and methods. A total of 1873 primary patients with ALL aged 1 to 18 years, of whom 1544 patients were enrolled in this study, were notified at 36 clinics of Russia and Belarus from April 15, 2002, to January 1, 2008.
Results. With the median observation of 4.12 years, 7-year event-free survival (EFS) was 73±13%; overall survival (OS) 78±2%; relapse-free survival 82±1%. The rates of EFS and OS were equal and amounted to 76±2 and 80±2% in the standard-risk group (SRG) and intermediate-risk group (ImRG), respectively. In the high-risk group (HRG) patients, EFS and OS were as high as 30±6 and 37±6%, respectively. The frequency of relapses with central nervous system lesion was as much as 4.7% in all the patients, 6-year cumulative risk for isolated neurorecurrences being 2.5% in the SRG patients. Adolescents, patients with the baseline leukocytosis (more than 100109/l), and those with a splenic size of over 4 cm or more from the costal arch margin had substantially worse survival rates. A poor early response to therapy (on induction days 8 and 15) was also associated with its lower efficiency.
Conclusion. Despite a considerable rise in the number of centers and a slight increase in the intensity of therapy, the results of the new ALL-MB-2002 protocol are as minimum equivalents obtained in the use of the previous ALL-MB-91 protocol. A significant improvement in the overall results of therapy and a reduction in the cumulative risk for isolated neurorecurrences were noted in the ImRG patients. |
| first_indexed | 2024-12-21T20:23:31Z |
| format | Article |
| id | doaj.art-cfbc2ada713446ef93c73a86b57fd3bc |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-21T20:23:31Z |
| publishDate | 2010-07-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-cfbc2ada713446ef93c73a86b57fd3bc2022-12-21T18:51:26Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422010-07-01827111927620Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemiaYu V Rumyantseva0A I Karachunsky1O V Aleinikova2L G Fechina3A V Shamardina4D V Litvinov5N I Ponomareva6E G Boichenko7S A Dudkin8O V Streneva9K L Kondratchik10E G Mansurova11L M Minkina12E S Lapotentova13E V Inyushkina14N B Yudina15G P Pavlova16E V Zhukovskaya17O P Khlebnikova18S N Lagoiko19E V Basharova20R E Denisov21V D Zlobina22E S Banshchikova23K S Aslanyan24E V Kondakova25E V Tselousova26N V Myakova27T V Turobova28O V Ryskal29N F Chipsanova30S R Varfolomeyeva31A G Rumyantsev32Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRepublican Research and Practical Center of Pediatric Oncology and Hematology, Minsk, BelarusCenter of Oncology and Hematology, Regional Children's Hospital One, YekaterinburgRegional Children's Hospital, Nizhni NovgorodFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRepublican Children's Hospital, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRepublican Children's Hospital, MoscowChildren's Hospital One, Saint PetersburgTown Children's Hospital Four, NovokuznetskCenter of Oncology and Hematology, Regional Children's Hospital One, YekaterinburgMorozov City Children's Hospital, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowChildren's Town Hospital, VladivostokRepublican Research and Practical Center of Pediatric Oncology and Hematology, Minsk, BelarusMoscow Regional Cancer Dispensary, Balashikha, Moscow RegionRegional Children's Hospital One, VoronezhRegional Children's Hospital, Ministry of Health and Social Development of Chuvash Republic, CheboksaryRegional Children's Hospital, ChelyabinskCenter of Oncology and Hematology, Regional Children's Hospital One, YekaterinburgFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRegional Children's Hospital, ChelyabinskRegional Children's Hospital, ChelyabinskCentral District Hospital, NovosibirskRegional Hospital One - NCM (National Center of Medicine), YakutskRegional Children's Hospital, Rostov-on-DonSurgut District Hospital, UHMAU-Ugry, SurgutKirov Research Institute of Hematology and Blood TransfusionFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRepublican Children's Hospital, MoscowRegional Children's Hospital, ArkhangelskRegional Children's Hospital, PermKomi Republican Cardiology Dispensary, SyktyvkarFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowAim. To evaluate the efficiency of the original ALL-MB-2002 protocol within the multicenter study of treatment of acute lymphoblastic leukemia (ALL) in children. Subjects and methods. A total of 1873 primary patients with ALL aged 1 to 18 years, of whom 1544 patients were enrolled in this study, were notified at 36 clinics of Russia and Belarus from April 15, 2002, to January 1, 2008. Results. With the median observation of 4.12 years, 7-year event-free survival (EFS) was 73±13%; overall survival (OS) 78±2%; relapse-free survival 82±1%. The rates of EFS and OS were equal and amounted to 76±2 and 80±2% in the standard-risk group (SRG) and intermediate-risk group (ImRG), respectively. In the high-risk group (HRG) patients, EFS and OS were as high as 30±6 and 37±6%, respectively. The frequency of relapses with central nervous system lesion was as much as 4.7% in all the patients, 6-year cumulative risk for isolated neurorecurrences being 2.5% in the SRG patients. Adolescents, patients with the baseline leukocytosis (more than 100109/l), and those with a splenic size of over 4 cm or more from the costal arch margin had substantially worse survival rates. A poor early response to therapy (on induction days 8 and 15) was also associated with its lower efficiency. Conclusion. Despite a considerable rise in the number of centers and a slight increase in the intensity of therapy, the results of the new ALL-MB-2002 protocol are as minimum equivalents obtained in the use of the previous ALL-MB-91 protocol. A significant improvement in the overall results of therapy and a reduction in the cumulative risk for isolated neurorecurrences were noted in the ImRG patients.https://ter-arkhiv.ru/0040-3660/article/view/30592acute lymphoblastic leukemiachildrenefficiency of therapy |
| spellingShingle | Yu V Rumyantseva A I Karachunsky O V Aleinikova L G Fechina A V Shamardina D V Litvinov N I Ponomareva E G Boichenko S A Dudkin O V Streneva K L Kondratchik E G Mansurova L M Minkina E S Lapotentova E V Inyushkina N B Yudina G P Pavlova E V Zhukovskaya O P Khlebnikova S N Lagoiko E V Basharova R E Denisov V D Zlobina E S Banshchikova K S Aslanyan E V Kondakova E V Tselousova N V Myakova T V Turobova O V Ryskal N F Chipsanova S R Varfolomeyeva A G Rumyantsev Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia Терапевтический архив acute lymphoblastic leukemia children efficiency of therapy |
| title | Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia |
| title_full | Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia |
| title_fullStr | Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia |
| title_full_unstemmed | Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia |
| title_short | Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia |
| title_sort | efficiency of the all mb 2002 protocol in children with acute lymphoblastic leukemia |
| topic | acute lymphoblastic leukemia children efficiency of therapy |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30592 |
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