| Summary: | Fungal mycelium cultures are an alternative to natural sources in order to obtain valuable research materials. They also enable constant control and adaptation of the process, thereby leading to increased biomass growth and accumulation of bioactive metabolites. The present study aims to assess the biosynthetic potential of mycelial cultures of six <i>Ganoderma</i> species: <i>G. adspersum</i>, <i>G.</i> <i>applanatum</i>, <i>G. carnosum</i>, <i>G. lucidum</i>, <i>G. pfeifferi</i>, and <i>G. resinaceum</i>. The presence of phenolic acids, amino acids, indole compounds, sterols, and kojic acid in biomass extracts was determined by HPLC. The antioxidant and cytotoxic activities of the extracts and their effects on the inhibition of selected enzymes (tyrosinase and acetylcholinesterase) were also evaluated. The total content of phenolic acids in the extracts ranged from 5.8 (<i>G. carnosum</i>) to 114.07 mg/100 g dry weight (d.w.) (<i>G. pfeifferi</i>). The total content of indole compounds in the extracts ranged from 3.03 (<i>G. carnosum</i>) to 11.56 mg/100 g d.w. (<i>G. lucidum</i>) and that of ergosterol ranged from 28.15 (<i>G. applanatum</i>) to 74.78 mg/100 g d.w. (<i>G. adspersum</i>). Kojic acid was found in the extracts of <i>G. applanatum</i> and <i>G. lucidum</i>. The tested extracts showed significant antioxidant activity. The results suggest that the analyzed mycelial cultures are promising candidates for the development of new dietary supplements or pharmaceutical preparations.
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