THE CORRELATION AMONG BCL-2, CERB B-2 LEVELS AND PROGNOSTIC FACTORS IN THE EARLY AND LOCALLY ADVANCED STAGE BREAST CANCER
AİM:To investigate the correlation among Bcl-2 and C erbB-2 and classical prognostic factors in patients with breast cancer. In addition we aimed to investigate the effects of neoadjuvant chemotherapy to these prognostic factors our patients with stage III breast cancer.MATERİAL AND METHOD:In the st...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2006-01-01
|
| Series: | European Journal of Breast Health |
| Online Access: |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/the-correlaton-among-bcl-2-cerb-b-2-levels-and-pro/42740
|
| _version_ | 1797909363038355456 |
|---|---|
| author | Yücel Arıtaş Alper Akcan Turgut Köse Tarık Artış Namık Yılmaz Hızır Akyıldız Turhan Ökten |
| author_facet | Yücel Arıtaş Alper Akcan Turgut Köse Tarık Artış Namık Yılmaz Hızır Akyıldız Turhan Ökten |
| author_sort | Yücel Arıtaş |
| collection | DOAJ |
| description | AİM:To investigate the correlation among Bcl-2 and C erbB-2 and classical prognostic factors in patients with breast cancer. In addition we aimed to investigate the effects of neoadjuvant chemotherapy to these prognostic factors our patients with stage III breast cancer.MATERİAL AND METHOD:In the study, 20 patients with the diagnosis of fibroadenoma were assigned as the control group (Group 1). There were 4 study groups: 20 patients who were diagnosed as stage I, II breast cancer(Group 2). 20 patients found as stage III breast cancer according to evaluation of the pathological specimens(Group 3), neoadjuvant chemotherapy receiving 16 patients whom diseases were accepted as stage III after physical examination and imaging studies(Group 4), 10 of the group 4 patients who underwent surgical treatment after neoadjuvant chemotherapy (Group 5). Modified radical mastectomy was performed in the study groups and excisional biopsy for the control group. Specimens were evaluated for Bcl-2, C erbB-2.RESULTS:Statistical significance was found for Bcl-2 positivity among the groups(p<0.05). Estrogen and progesteron receptor levels were found significantly higher(p<0.05) in Bcl-2 positive, and lower in C erbB-2 positive patients. In Bcl-2 positive patients axillary lymph node involvement was lesser, and was higher in C erbB-2, but was not statistically significant(p>0.05). Groups 4 and 5 were not statistically different for Bcl-2 and C erbB-2 status(p>0.05).CONCLUSİON:Besides the classical prognostic factors, Bcl-2 and C erbB-2 levels may predict the prognosis and response to the treatment. |
| first_indexed | 2024-04-10T11:07:01Z |
| format | Article |
| id | doaj.art-cfbf91fb804042f787c29900e4780115 |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T11:07:01Z |
| publishDate | 2006-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-cfbf91fb804042f787c29900e47801152023-02-15T16:19:21ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312006-01-012171113049054THE CORRELATION AMONG BCL-2, CERB B-2 LEVELS AND PROGNOSTIC FACTORS IN THE EARLY AND LOCALLY ADVANCED STAGE BREAST CANCERYücel Arıtaş0Alper Akcan1Turgut Köse2Tarık Artış3Namık Yılmaz4Hızır Akyıldız5Turhan Ökten6 Erciyes Üniversitesi Tıp Fakültesi, Genel Cerrahi AD, Kayseri, Türkiye Erciyes Üniversitesi Tıp Fakültesi, Genel Cerrahi AD, Kayseri, Türkiye Erciyes Üniversitesi Tıp Fakültesi, Genel Cerrahi AD, Kayseri, Türkiye Erciyes Üniversitesi Tıp Fakültesi, Genel Cerrahi AD, Kayseri, Türkiye Erciyes Üniversitesi Tıp Fakültesi, Genel Cerrahi AD, Kayseri, Türkiye Erciyes Üniversitesi Tıp Fakültesi, Genel Cerrahi AD, Kayseri, Türkiye Erciyes Üniversitesi Tıp Fakültesi, Patoloji AD, Kayseri, Türkiye AİM:To investigate the correlation among Bcl-2 and C erbB-2 and classical prognostic factors in patients with breast cancer. In addition we aimed to investigate the effects of neoadjuvant chemotherapy to these prognostic factors our patients with stage III breast cancer.MATERİAL AND METHOD:In the study, 20 patients with the diagnosis of fibroadenoma were assigned as the control group (Group 1). There were 4 study groups: 20 patients who were diagnosed as stage I, II breast cancer(Group 2). 20 patients found as stage III breast cancer according to evaluation of the pathological specimens(Group 3), neoadjuvant chemotherapy receiving 16 patients whom diseases were accepted as stage III after physical examination and imaging studies(Group 4), 10 of the group 4 patients who underwent surgical treatment after neoadjuvant chemotherapy (Group 5). Modified radical mastectomy was performed in the study groups and excisional biopsy for the control group. Specimens were evaluated for Bcl-2, C erbB-2.RESULTS:Statistical significance was found for Bcl-2 positivity among the groups(p<0.05). Estrogen and progesteron receptor levels were found significantly higher(p<0.05) in Bcl-2 positive, and lower in C erbB-2 positive patients. In Bcl-2 positive patients axillary lymph node involvement was lesser, and was higher in C erbB-2, but was not statistically significant(p>0.05). Groups 4 and 5 were not statistically different for Bcl-2 and C erbB-2 status(p>0.05).CONCLUSİON:Besides the classical prognostic factors, Bcl-2 and C erbB-2 levels may predict the prognosis and response to the treatment. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/the-correlaton-among-bcl-2-cerb-b-2-levels-and-pro/42740 |
| spellingShingle | Yücel Arıtaş Alper Akcan Turgut Köse Tarık Artış Namık Yılmaz Hızır Akyıldız Turhan Ökten THE CORRELATION AMONG BCL-2, CERB B-2 LEVELS AND PROGNOSTIC FACTORS IN THE EARLY AND LOCALLY ADVANCED STAGE BREAST CANCER European Journal of Breast Health |
| title | THE CORRELATION AMONG BCL-2, CERB B-2 LEVELS AND PROGNOSTIC FACTORS IN THE EARLY AND LOCALLY ADVANCED STAGE BREAST CANCER |
| title_full | THE CORRELATION AMONG BCL-2, CERB B-2 LEVELS AND PROGNOSTIC FACTORS IN THE EARLY AND LOCALLY ADVANCED STAGE BREAST CANCER |
| title_fullStr | THE CORRELATION AMONG BCL-2, CERB B-2 LEVELS AND PROGNOSTIC FACTORS IN THE EARLY AND LOCALLY ADVANCED STAGE BREAST CANCER |
| title_full_unstemmed | THE CORRELATION AMONG BCL-2, CERB B-2 LEVELS AND PROGNOSTIC FACTORS IN THE EARLY AND LOCALLY ADVANCED STAGE BREAST CANCER |
| title_short | THE CORRELATION AMONG BCL-2, CERB B-2 LEVELS AND PROGNOSTIC FACTORS IN THE EARLY AND LOCALLY ADVANCED STAGE BREAST CANCER |
| title_sort | correlation among bcl 2 cerb b 2 levels and prognostic factors in the early and locally advanced stage breast cancer |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/the-correlaton-among-bcl-2-cerb-b-2-levels-and-pro/42740
|
| work_keys_str_mv | AT yucelarıtas thecorrelationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT alperakcan thecorrelationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT turgutkose thecorrelationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT tarıkartıs thecorrelationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT namıkyılmaz thecorrelationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT hızırakyıldız thecorrelationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT turhanokten thecorrelationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT yucelarıtas correlationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT alperakcan correlationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT turgutkose correlationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT tarıkartıs correlationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT namıkyılmaz correlationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT hızırakyıldız correlationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer AT turhanokten correlationamongbcl2cerbb2levelsandprognosticfactorsintheearlyandlocallyadvancedstagebreastcancer |