Treatment of deep second-degree burns on the abdomen, thighs, and genitalia: use of tilapia skin as a xenograft
Tilapia skin has a non-infectious microbiota and a morphological structure similar to human skin. Phase II clinical studies, not yet published, have shown promising results in their use for the treatment of burns. In the protocols of these studies, patients with lesions in areas of skin folds, such...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Cirurgia Plástica
2020-06-01
|
| Series: | Revista Brasileira de Cirurgia Plástica |
| Subjects: | |
| Online Access: | http://www.rbcp.org.br/export-pdf/2755/en_v35n2a17.pdf |
| _version_ | 1797425084970827776 |
|---|---|
| author | Edmar Maciel Lima Manoel Odorico Moraes Bruno Almeida Costa Alex Marques Do Nascimento Uchôa Camila Barroso Martins Maria Elisabete Amaral De Moraes Marina Becker Sales Rocha Francisco Vagnaldo Fechine |
| author_facet | Edmar Maciel Lima Manoel Odorico Moraes Bruno Almeida Costa Alex Marques Do Nascimento Uchôa Camila Barroso Martins Maria Elisabete Amaral De Moraes Marina Becker Sales Rocha Francisco Vagnaldo Fechine |
| author_sort | Edmar Maciel Lima |
| collection | DOAJ |
| description | Tilapia skin has a non-infectious microbiota and a morphological structure similar to human skin. Phase II clinical studies, not yet published, have shown promising results in their use for the treatment of burns. In the protocols of these studies, patients with lesions in areas of skin folds, such as genitals and inguinal regions, were excluded, as it was thought that the biomaterial would not adhere properly, resulting in a lower degree of healing. Case report of a female patient, 18 years old, without comorbidities, with deep second-degree burns in the abdomen, inguinal region, part of the genitalia and upper half of both thighs, involving 13.5% of the total body surface area. Tilapia skin was applied to the lesions leading to a complete re-epithelialization with 16 days of treatment. No side effects were observed. Tilapia skin, therefore, brings the promise of an innovative product, easy to apply, and highly available, which can become the first animal skin nationally studied and registered by the Agência Nacional de Vigilância Sanitária, for use in the treatment of burns. This case report contributes to reduce the limitations concerning the anatomical areas appropriate for the application of tilapia skin, since, even with the need for skin replacement, good results were obtained with application to the genitalia and inguinal region. |
| first_indexed | 2024-03-09T08:10:56Z |
| format | Article |
| id | doaj.art-cfc00c87a7594c6a82e92461bd6412fe |
| institution | Directory Open Access Journal |
| issn | 1983-5175 2177-1235 |
| language | English |
| last_indexed | 2024-03-09T08:10:56Z |
| publishDate | 2020-06-01 |
| publisher | Sociedade Brasileira de Cirurgia Plástica |
| record_format | Article |
| series | Revista Brasileira de Cirurgia Plástica |
| spelling | doaj.art-cfc00c87a7594c6a82e92461bd6412fe2023-12-02T23:25:41ZengSociedade Brasileira de Cirurgia PlásticaRevista Brasileira de Cirurgia Plástica1983-51752177-12352020-06-01350224324810.5935/2177-1235.2020RBCP0040Treatment of deep second-degree burns on the abdomen, thighs, and genitalia: use of tilapia skin as a xenograftEdmar Maciel Lima0Manoel Odorico Moraes1Bruno Almeida Costa2Alex Marques Do Nascimento Uchôa3Camila Barroso Martins4Maria Elisabete Amaral De Moraes5Marina Becker Sales Rocha6Francisco Vagnaldo Fechine7Instituto Dr. José Frota, Centro de Tratamento de Queimados, Fortaleza, CE, BrazilUniversidade Federal do Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Unidade de Farmacologia Clínica, Fortaleza, CE, BrazilUniversidade Federal do Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Unidade de Farmacologia Clínica, Fortaleza, CE, BrazilUniversidade Federal do Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Unidade de Farmacologia Clínica, Fortaleza, CE, BrazilUniversidade Federal do Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Unidade de Farmacologia Clínica, Fortaleza, CE, BrazilUniversidade Federal do Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Unidade de Farmacologia Clínica, Fortaleza, CE, BrazilUniversidade Federal do Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Unidade de Farmacologia Clínica, Fortaleza, CE, BrazilUniversidade Federal do Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Unidade de Farmacologia Clínica, Fortaleza, CE, BrazilTilapia skin has a non-infectious microbiota and a morphological structure similar to human skin. Phase II clinical studies, not yet published, have shown promising results in their use for the treatment of burns. In the protocols of these studies, patients with lesions in areas of skin folds, such as genitals and inguinal regions, were excluded, as it was thought that the biomaterial would not adhere properly, resulting in a lower degree of healing. Case report of a female patient, 18 years old, without comorbidities, with deep second-degree burns in the abdomen, inguinal region, part of the genitalia and upper half of both thighs, involving 13.5% of the total body surface area. Tilapia skin was applied to the lesions leading to a complete re-epithelialization with 16 days of treatment. No side effects were observed. Tilapia skin, therefore, brings the promise of an innovative product, easy to apply, and highly available, which can become the first animal skin nationally studied and registered by the Agência Nacional de Vigilância Sanitária, for use in the treatment of burns. This case report contributes to reduce the limitations concerning the anatomical areas appropriate for the application of tilapia skin, since, even with the need for skin replacement, good results were obtained with application to the genitalia and inguinal region.http://www.rbcp.org.br/export-pdf/2755/en_v35n2a17.pdfburnstilapiabiological dressingsbiocompatible materialscichlids |
| spellingShingle | Edmar Maciel Lima Manoel Odorico Moraes Bruno Almeida Costa Alex Marques Do Nascimento Uchôa Camila Barroso Martins Maria Elisabete Amaral De Moraes Marina Becker Sales Rocha Francisco Vagnaldo Fechine Treatment of deep second-degree burns on the abdomen, thighs, and genitalia: use of tilapia skin as a xenograft Revista Brasileira de Cirurgia Plástica burns tilapia biological dressings biocompatible materials cichlids |
| title | Treatment of deep second-degree burns on the
abdomen, thighs, and genitalia: use of tilapia skin as
a xenograft |
| title_full | Treatment of deep second-degree burns on the
abdomen, thighs, and genitalia: use of tilapia skin as
a xenograft |
| title_fullStr | Treatment of deep second-degree burns on the
abdomen, thighs, and genitalia: use of tilapia skin as
a xenograft |
| title_full_unstemmed | Treatment of deep second-degree burns on the
abdomen, thighs, and genitalia: use of tilapia skin as
a xenograft |
| title_short | Treatment of deep second-degree burns on the
abdomen, thighs, and genitalia: use of tilapia skin as
a xenograft |
| title_sort | treatment of deep second degree burns on the abdomen thighs and genitalia use of tilapia skin as a xenograft |
| topic | burns tilapia biological dressings biocompatible materials cichlids |
| url | http://www.rbcp.org.br/export-pdf/2755/en_v35n2a17.pdf |
| work_keys_str_mv | AT edmarmaciellima treatmentofdeepseconddegreeburnsontheabdomenthighsandgenitaliauseoftilapiaskinasaxenograft AT manoelodoricomoraes treatmentofdeepseconddegreeburnsontheabdomenthighsandgenitaliauseoftilapiaskinasaxenograft AT brunoalmeidacosta treatmentofdeepseconddegreeburnsontheabdomenthighsandgenitaliauseoftilapiaskinasaxenograft AT alexmarquesdonascimentouchoa treatmentofdeepseconddegreeburnsontheabdomenthighsandgenitaliauseoftilapiaskinasaxenograft AT camilabarrosomartins treatmentofdeepseconddegreeburnsontheabdomenthighsandgenitaliauseoftilapiaskinasaxenograft AT mariaelisabeteamaraldemoraes treatmentofdeepseconddegreeburnsontheabdomenthighsandgenitaliauseoftilapiaskinasaxenograft AT marinabeckersalesrocha treatmentofdeepseconddegreeburnsontheabdomenthighsandgenitaliauseoftilapiaskinasaxenograft AT franciscovagnaldofechine treatmentofdeepseconddegreeburnsontheabdomenthighsandgenitaliauseoftilapiaskinasaxenograft |