Novel mechanisms for action of extremal agents: the role of transforming growth factor type beta
The article summarizes the results obtained during the last years at the Department headed by the article author, as well as literature data, on the role of transforming growth factor type beta in the action towards animal and human organisms of extremal agents of different nature – chemical, physic...
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| Format: | Article |
| Language: | English |
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Львівський національний університет імені Івана Франка
2008-09-01
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| Series: | Біологічні студії |
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| Online Access: | http://publications.lnu.edu.ua/journals/index.php/biology/article/view/495 |
| _version_ | 1818438746547159040 |
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| author | R. S. Stoika |
| author_facet | R. S. Stoika |
| author_sort | R. S. Stoika |
| collection | DOAJ |
| description | The article summarizes the results obtained during the last years at the Department headed by the article author, as well as literature data, on the role of transforming growth factor type beta in the action towards animal and human organisms of extremal agents of different nature – chemical, physical, mechanical, pathobiological. It is demonstrated that those agents can stimulate the mammalian cells to production of that cytokine which acts as growth inhibitor and apoptosis inducer for cells of epithelial origin and for most immunocompetent cells. The mechanisms used by tumor cells to achieve their resistance to the effect of this cytokine, that can help them to escape of its inhibitory action, are described. |
| first_indexed | 2024-12-14T17:45:28Z |
| format | Article |
| id | doaj.art-cfc0fb9434fd4aeab1b6edbe71b5d112 |
| institution | Directory Open Access Journal |
| issn | 1996-4536 2311-0783 |
| language | English |
| last_indexed | 2024-12-14T17:45:28Z |
| publishDate | 2008-09-01 |
| publisher | Львівський національний університет імені Івана Франка |
| record_format | Article |
| series | Біологічні студії |
| spelling | doaj.art-cfc0fb9434fd4aeab1b6edbe71b5d1122022-12-21T22:52:45ZengЛьвівський національний університет імені Івана ФранкаБіологічні студії1996-45362311-07832008-09-012132010.30970/sbi.0201.009Novel mechanisms for action of extremal agents: the role of transforming growth factor type betaR. S. Stoika0https://orcid.org/0000-0001-5719-2187Institute of Cell Biology, NAS of UkraineThe article summarizes the results obtained during the last years at the Department headed by the article author, as well as literature data, on the role of transforming growth factor type beta in the action towards animal and human organisms of extremal agents of different nature – chemical, physical, mechanical, pathobiological. It is demonstrated that those agents can stimulate the mammalian cells to production of that cytokine which acts as growth inhibitor and apoptosis inducer for cells of epithelial origin and for most immunocompetent cells. The mechanisms used by tumor cells to achieve their resistance to the effect of this cytokine, that can help them to escape of its inhibitory action, are described.http://publications.lnu.edu.ua/journals/index.php/biology/article/view/495extremal agentstransforming growth factor type betatumor cellsimmunocompetent cellsmechanismsresistance |
| spellingShingle | R. S. Stoika Novel mechanisms for action of extremal agents: the role of transforming growth factor type beta Біологічні студії extremal agents transforming growth factor type beta tumor cells immunocompetent cells mechanisms resistance |
| title | Novel mechanisms for action of extremal agents: the role of transforming growth factor type beta |
| title_full | Novel mechanisms for action of extremal agents: the role of transforming growth factor type beta |
| title_fullStr | Novel mechanisms for action of extremal agents: the role of transforming growth factor type beta |
| title_full_unstemmed | Novel mechanisms for action of extremal agents: the role of transforming growth factor type beta |
| title_short | Novel mechanisms for action of extremal agents: the role of transforming growth factor type beta |
| title_sort | novel mechanisms for action of extremal agents the role of transforming growth factor type beta |
| topic | extremal agents transforming growth factor type beta tumor cells immunocompetent cells mechanisms resistance |
| url | http://publications.lnu.edu.ua/journals/index.php/biology/article/view/495 |
| work_keys_str_mv | AT rsstoika novelmechanismsforactionofextremalagentstheroleoftransforminggrowthfactortypebeta |