Longitudinal association between dietary protein intake and survival in peritoneal dialysis patients
AbstractBackground Decreased dietary protein intake (DPI) may lead to protein-energy malnutrition and may be associated with increased mortality risk. We hypothesized that longitudinal changes in dietary protein intake have independent associations with survival in peritoneal dialysis (PD) patients....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2182605 |
| _version_ | 1797658463762907136 |
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| author | Shu-Hong Bi Xiaoxiao Wang Wen Tang Tao Wang Baohua Li Chunyan Su |
| author_facet | Shu-Hong Bi Xiaoxiao Wang Wen Tang Tao Wang Baohua Li Chunyan Su |
| author_sort | Shu-Hong Bi |
| collection | DOAJ |
| description | AbstractBackground Decreased dietary protein intake (DPI) may lead to protein-energy malnutrition and may be associated with increased mortality risk. We hypothesized that longitudinal changes in dietary protein intake have independent associations with survival in peritoneal dialysis (PD) patients.Methods 668 stable PD patients were selected in the study from January 2006 to January 2018 and were followed up until December 2019. Their three-day dietary records were collected at the baseline (the sixth month after PD) and thereafter every 3 months for two and a half years. The latent class mixed models (LCMM) were used to identify subgroups of PD patients with similar longitudinal trajectories of DPI. The relation between DPI (baseline and longitudinal data) and survival was examined using Cox model to estimate death hazard ratios. Meanwhile, different formulae were used to assess nitrogen balance.Results The results showed that baseline DPI ≤ 0.60g/kg/day was associated with the worst outcome in PD patients. Patients with DPI 0.80–0.99g/kg/day and DPI ≥ 1.0g/kg/day both presented positive nitrogen balance; patients with DPI 0.61–0.79g/kg/day presented obviously negative nitrogen balance. Longitudinal association between time-dependent DPI and survival was found in PD patients. The consistently low DPI' (0.61–0.79g/kg/d) group was correlated with increased death risk as compared with the 'consistently median DPI' group (0.80–0.99g/kg/d, HR = 1.59, p = 0.008), whereas there was no difference in survival between 'consistently median DPI' group and 'high-level DPI' group (≥1.0 g/kg/d, p > 0.05).Conclusion Our study revealed that DPI ≥ 0.8 g/kg/day was beneficial to the long-term outcome for the PD population. |
| first_indexed | 2024-03-11T18:00:26Z |
| format | Article |
| id | doaj.art-cfc161f8b5c8485baf80cd323c70b178 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-03-11T18:00:26Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-cfc161f8b5c8485baf80cd323c70b1782023-10-17T09:23:24ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2182605Longitudinal association between dietary protein intake and survival in peritoneal dialysis patientsShu-Hong Bi0Xiaoxiao Wang1Wen Tang2Tao Wang3Baohua Li4Chunyan Su5Department of Nephrology, Peking University Third Hospital, Beijing, ChinaResearch Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, ChinaDepartment of Nephrology, Peking University Third Hospital, Beijing, ChinaDepartment of Nephrology, Peking University Third Hospital, Beijing, ChinaNursing Department, Peking University Third Hospital, Beijing, ChinaDepartment of Nephrology, Peking University Third Hospital, Beijing, ChinaAbstractBackground Decreased dietary protein intake (DPI) may lead to protein-energy malnutrition and may be associated with increased mortality risk. We hypothesized that longitudinal changes in dietary protein intake have independent associations with survival in peritoneal dialysis (PD) patients.Methods 668 stable PD patients were selected in the study from January 2006 to January 2018 and were followed up until December 2019. Their three-day dietary records were collected at the baseline (the sixth month after PD) and thereafter every 3 months for two and a half years. The latent class mixed models (LCMM) were used to identify subgroups of PD patients with similar longitudinal trajectories of DPI. The relation between DPI (baseline and longitudinal data) and survival was examined using Cox model to estimate death hazard ratios. Meanwhile, different formulae were used to assess nitrogen balance.Results The results showed that baseline DPI ≤ 0.60g/kg/day was associated with the worst outcome in PD patients. Patients with DPI 0.80–0.99g/kg/day and DPI ≥ 1.0g/kg/day both presented positive nitrogen balance; patients with DPI 0.61–0.79g/kg/day presented obviously negative nitrogen balance. Longitudinal association between time-dependent DPI and survival was found in PD patients. The consistently low DPI' (0.61–0.79g/kg/d) group was correlated with increased death risk as compared with the 'consistently median DPI' group (0.80–0.99g/kg/d, HR = 1.59, p = 0.008), whereas there was no difference in survival between 'consistently median DPI' group and 'high-level DPI' group (≥1.0 g/kg/d, p > 0.05).Conclusion Our study revealed that DPI ≥ 0.8 g/kg/day was beneficial to the long-term outcome for the PD population.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2182605Malnutritiondaily protein intakeperitoneal dialysissurvivalnitrogen balance |
| spellingShingle | Shu-Hong Bi Xiaoxiao Wang Wen Tang Tao Wang Baohua Li Chunyan Su Longitudinal association between dietary protein intake and survival in peritoneal dialysis patients Renal Failure Malnutrition daily protein intake peritoneal dialysis survival nitrogen balance |
| title | Longitudinal association between dietary protein intake and survival in peritoneal dialysis patients |
| title_full | Longitudinal association between dietary protein intake and survival in peritoneal dialysis patients |
| title_fullStr | Longitudinal association between dietary protein intake and survival in peritoneal dialysis patients |
| title_full_unstemmed | Longitudinal association between dietary protein intake and survival in peritoneal dialysis patients |
| title_short | Longitudinal association between dietary protein intake and survival in peritoneal dialysis patients |
| title_sort | longitudinal association between dietary protein intake and survival in peritoneal dialysis patients |
| topic | Malnutrition daily protein intake peritoneal dialysis survival nitrogen balance |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2182605 |
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