Phytochemical derivatives and secondary metabolites rich Rhizophora mucronata as an active anti-oxidant and anti-bacterial agent against multi drug resistant bacteria
In the present study, the phytochemicals and anti-oxidant ability rich marine mangrove plant Rhizophora mucronata (R. mucronata) was evaluated. The UV-bio spectrometer result of O.D value of phenolic content was shown 0.986 as well as flavonoid content were shown 0.994 at 100 µg/mL concentration. Th...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364723003749 |
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| author | Chenthis Kanisha Chelliah Manavalan Murugan Govindan Rajivgandhi Chackaravarthi Gnanasekaran Ramachandran Govindan Muthuchamy Maruthupandy Franck Quero Arunachalam Arulraj Mangalaraja Ramalinga Viswanathan Naiyf S. Alharbi Naif Hilal Alshammary |
| author_facet | Chenthis Kanisha Chelliah Manavalan Murugan Govindan Rajivgandhi Chackaravarthi Gnanasekaran Ramachandran Govindan Muthuchamy Maruthupandy Franck Quero Arunachalam Arulraj Mangalaraja Ramalinga Viswanathan Naiyf S. Alharbi Naif Hilal Alshammary |
| author_sort | Chenthis Kanisha Chelliah |
| collection | DOAJ |
| description | In the present study, the phytochemicals and anti-oxidant ability rich marine mangrove plant Rhizophora mucronata (R. mucronata) was evaluated. The UV-bio spectrometer result of O.D value of phenolic content was shown 0.986 as well as flavonoid content were shown 0.994 at 100 µg/mL concentration. The high yields of phenol and flavonoid contents were observed compared with standard gallic acid and rutin. Concisely, the more phenols and flavonoids and some bioactive derivatives were clearly exhibited by LC-MS scanning report. In addition, the anti-oxidant activity result shown with 85 % and DPPH scavenging assay result shown 66% in crude extract of R. mucronata were observed and it was very higher than the rate of standard gallic acid and ascorbic acid. Further, the liquid–liquid extraction of available bioactive compounds were purified and shown excellent anti-bacterial activity against multi drug resistant bacteria. The anti-microbial activity result indicated that the 250 µg/mL of R. mucronata extract was shown 24 and 26 mm zone of inhibition against K. pneumoniae and A. baumannii. Then, the concentration dependent inhibition of R. mucronata extract was shown against both the tested pathogens and 250 µg/m concentrations was fixed as a minimum inhibition concentration range. Finally, the induction of outer cellular layer morphology effect and damaged size and shapes of the R. mucronata extract was shown against K. pneumoniae and A. baumannii. Altogether, the present study results were deliberately recommended that the R. mucronata extract as potential anti-oxidant and anti-bacterial agent. Hence, the natural marine mangrove plant R. mucronata is the safe, eco-friendly, low cost source for discovery of potential drug against various infections. |
| first_indexed | 2024-03-11T16:52:45Z |
| format | Article |
| id | doaj.art-cfc1e6e92f6e44798b45802f95dbba5b |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-03-11T16:52:45Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-cfc1e6e92f6e44798b45802f95dbba5b2023-10-21T04:22:17ZengElsevierJournal of King Saud University: Science1018-36472023-11-01358102912Phytochemical derivatives and secondary metabolites rich Rhizophora mucronata as an active anti-oxidant and anti-bacterial agent against multi drug resistant bacteriaChenthis Kanisha Chelliah0Manavalan Murugan1Govindan Rajivgandhi2Chackaravarthi Gnanasekaran3Ramachandran Govindan4Muthuchamy Maruthupandy5Franck Quero6Arunachalam Arulraj7Mangalaraja Ramalinga Viswanathan8Naiyf S. Alharbi9Naif Hilal Alshammary10Department of Nanotechnology, Noorul Islam Centre for Higher Education, Kumaracoil, Kanyakumari, Tamil Nadu 629180, IndiaDepartment of Biomedical Engineering, Noorul Islam Centre for Higher Education, Kumaracoil, Kanyakumari, Tamil Nadu 629180, India; Corresponding author at: Department of Biomedical Engineering, Noorul Islam Centre for Higher Education, Kumaracoil, Kanyakumari, Tamil Nadu 629180, India.Laboratorio de Nanocelulosa y Biomateriales, Departamento de Ingeniería Química, Biotecnología y Materiales, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Avenida Beauchef 851, Santiago-8370456, ChileDepartment of Marine Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, IndiaDepartment of Marine Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, IndiaLab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, 37, Nakdong-Dearo 550 Beon-Gil, Saha-Gu Busan, 49315, South KoreaLaboratorio de Nanocelulosa y Biomateriales, Departamento de Ingeniería Química, Biotecnología y Materiales, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Avenida Beauchef 851, Santiago-8370456, ChileDepartamento de Electricidad, Facultad de Ingeniería, Universidad Tecnológica Metropolitana (UTEM), Macul, Santiago, ChileFaculty of Engineering and Sciences, Universidad Adolfo Ibáñez, Diag. Las Torres 2640, Peñalolén 7941169, Región Metropolitana, Santiago, ChileDepartment of Botany and Microbiology, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi ArabiaMicrobiology Department, King Khaled General Hospital, Hafer Albatin, Saudi ArabiaIn the present study, the phytochemicals and anti-oxidant ability rich marine mangrove plant Rhizophora mucronata (R. mucronata) was evaluated. The UV-bio spectrometer result of O.D value of phenolic content was shown 0.986 as well as flavonoid content were shown 0.994 at 100 µg/mL concentration. The high yields of phenol and flavonoid contents were observed compared with standard gallic acid and rutin. Concisely, the more phenols and flavonoids and some bioactive derivatives were clearly exhibited by LC-MS scanning report. In addition, the anti-oxidant activity result shown with 85 % and DPPH scavenging assay result shown 66% in crude extract of R. mucronata were observed and it was very higher than the rate of standard gallic acid and ascorbic acid. Further, the liquid–liquid extraction of available bioactive compounds were purified and shown excellent anti-bacterial activity against multi drug resistant bacteria. The anti-microbial activity result indicated that the 250 µg/mL of R. mucronata extract was shown 24 and 26 mm zone of inhibition against K. pneumoniae and A. baumannii. Then, the concentration dependent inhibition of R. mucronata extract was shown against both the tested pathogens and 250 µg/m concentrations was fixed as a minimum inhibition concentration range. Finally, the induction of outer cellular layer morphology effect and damaged size and shapes of the R. mucronata extract was shown against K. pneumoniae and A. baumannii. Altogether, the present study results were deliberately recommended that the R. mucronata extract as potential anti-oxidant and anti-bacterial agent. Hence, the natural marine mangrove plant R. mucronata is the safe, eco-friendly, low cost source for discovery of potential drug against various infections.http://www.sciencedirect.com/science/article/pii/S1018364723003749Mangrove regionEnvironmental parameterPhytochemical screeningAnti-oxidant activityBioactive materials |
| spellingShingle | Chenthis Kanisha Chelliah Manavalan Murugan Govindan Rajivgandhi Chackaravarthi Gnanasekaran Ramachandran Govindan Muthuchamy Maruthupandy Franck Quero Arunachalam Arulraj Mangalaraja Ramalinga Viswanathan Naiyf S. Alharbi Naif Hilal Alshammary Phytochemical derivatives and secondary metabolites rich Rhizophora mucronata as an active anti-oxidant and anti-bacterial agent against multi drug resistant bacteria Journal of King Saud University: Science Mangrove region Environmental parameter Phytochemical screening Anti-oxidant activity Bioactive materials |
| title | Phytochemical derivatives and secondary metabolites rich Rhizophora mucronata as an active anti-oxidant and anti-bacterial agent against multi drug resistant bacteria |
| title_full | Phytochemical derivatives and secondary metabolites rich Rhizophora mucronata as an active anti-oxidant and anti-bacterial agent against multi drug resistant bacteria |
| title_fullStr | Phytochemical derivatives and secondary metabolites rich Rhizophora mucronata as an active anti-oxidant and anti-bacterial agent against multi drug resistant bacteria |
| title_full_unstemmed | Phytochemical derivatives and secondary metabolites rich Rhizophora mucronata as an active anti-oxidant and anti-bacterial agent against multi drug resistant bacteria |
| title_short | Phytochemical derivatives and secondary metabolites rich Rhizophora mucronata as an active anti-oxidant and anti-bacterial agent against multi drug resistant bacteria |
| title_sort | phytochemical derivatives and secondary metabolites rich rhizophora mucronata as an active anti oxidant and anti bacterial agent against multi drug resistant bacteria |
| topic | Mangrove region Environmental parameter Phytochemical screening Anti-oxidant activity Bioactive materials |
| url | http://www.sciencedirect.com/science/article/pii/S1018364723003749 |
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