Assessing Liver Fibrosis Using 2D-SWE Liver Ultrasound Elastography and Dynamic Liver Scintigraphy with 99mTc-mebrofenin: A Comparative Prospective Single-Center Study
<i>Background and Objectives:</i> Many quantitative imaging modalities are available that quantify chronic liver disease, although only a few of them are included in clinical guidelines. Many more imaging options are still competing to find their place in the area of diagnosing chronic l...
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MDPI AG
2023-02-01
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| Online Access: | https://www.mdpi.com/1648-9144/59/3/479 |
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| author | Donatas Jocius Donatas Vajauskas Artūras Samuilis Kipras Mikelis Skirmante Jokubauskiene Kestutis Strupas Algirdas E. Tamosiunas |
| author_facet | Donatas Jocius Donatas Vajauskas Artūras Samuilis Kipras Mikelis Skirmante Jokubauskiene Kestutis Strupas Algirdas E. Tamosiunas |
| author_sort | Donatas Jocius |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Many quantitative imaging modalities are available that quantify chronic liver disease, although only a few of them are included in clinical guidelines. Many more imaging options are still competing to find their place in the area of diagnosing chronic liver disease. We report our first prospective single-center study evaluating different imaging modalities that stratify viral hepatitis-associated liver fibrosis in a treatment-naïve patient group. <i>Materials and Methods:</i> The aim of our study is to compare and to combine already employed 2D shear wave elastography (2D-SWE) with dynamic liver scintigraphy with 99mTc-mebrofenin in chronic viral hepatitis patients for the staging of liver fibrosis. <i>Results:</i> Seventy-two patients were enrolled in the study. We found that both 2D-SWE ultrasound imaging, with dynamic liver scintigraphy with 99mTc-mebrofenin are able to stratify CLD patients into different liver fibrosis categories based on histological examination findings. We did not find any statistically significant difference between these imaging options, which means that dynamic liver scintigraphy with 99mTc-mebrofenin is not an inferior imaging technique. A combination of these imaging modalities showed increased accuracy in the non-invasive staging of liver cirrhosis. <i>Conclusions:</i> Our study presents that 2D-SWE and dynamic liver scintigraphy with 99mTc-mebrofenin could be used for staging liver fibrosis, both in singular application and in a combined way, adding a potential supplementary value that represents different aspects of liver fibrosis in CLD. |
| first_indexed | 2024-03-11T06:12:41Z |
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| language | English |
| last_indexed | 2024-03-11T06:12:41Z |
| publishDate | 2023-02-01 |
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| series | Medicina |
| spelling | doaj.art-cfc222bc159445abaf7338890f0ef4e62023-11-17T12:31:13ZengMDPI AGMedicina1010-660X1648-91442023-02-0159347910.3390/medicina59030479Assessing Liver Fibrosis Using 2D-SWE Liver Ultrasound Elastography and Dynamic Liver Scintigraphy with 99mTc-mebrofenin: A Comparative Prospective Single-Center StudyDonatas Jocius0Donatas Vajauskas1Artūras Samuilis2Kipras Mikelis3Skirmante Jokubauskiene4Kestutis Strupas5Algirdas E. Tamosiunas6Department of Radiology, Nuclear Medicine and Medical Physics, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, LT-01513 Vilnius, LithuaniaDepartment of Radiology, Medical Academy, Lithuanian University of Health Science Kauno Klinikos, LT-44307 Kaunas, LithuaniaDepartment of Radiology, Nuclear Medicine and Medical Physics, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, LT-01513 Vilnius, LithuaniaDepartment of Radiology, Nuclear Medicine and Medical Physics, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, LT-01513 Vilnius, LithuaniaNational Center of Pathology, LT-01513 Vilnius, LithuaniaClinic of Gastroenterology, Nephro-Urology and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-01513 Vilnius, LithuaniaDepartment of Radiology, Nuclear Medicine and Medical Physics, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, LT-01513 Vilnius, Lithuania<i>Background and Objectives:</i> Many quantitative imaging modalities are available that quantify chronic liver disease, although only a few of them are included in clinical guidelines. Many more imaging options are still competing to find their place in the area of diagnosing chronic liver disease. We report our first prospective single-center study evaluating different imaging modalities that stratify viral hepatitis-associated liver fibrosis in a treatment-naïve patient group. <i>Materials and Methods:</i> The aim of our study is to compare and to combine already employed 2D shear wave elastography (2D-SWE) with dynamic liver scintigraphy with 99mTc-mebrofenin in chronic viral hepatitis patients for the staging of liver fibrosis. <i>Results:</i> Seventy-two patients were enrolled in the study. We found that both 2D-SWE ultrasound imaging, with dynamic liver scintigraphy with 99mTc-mebrofenin are able to stratify CLD patients into different liver fibrosis categories based on histological examination findings. We did not find any statistically significant difference between these imaging options, which means that dynamic liver scintigraphy with 99mTc-mebrofenin is not an inferior imaging technique. A combination of these imaging modalities showed increased accuracy in the non-invasive staging of liver cirrhosis. <i>Conclusions:</i> Our study presents that 2D-SWE and dynamic liver scintigraphy with 99mTc-mebrofenin could be used for staging liver fibrosis, both in singular application and in a combined way, adding a potential supplementary value that represents different aspects of liver fibrosis in CLD.https://www.mdpi.com/1648-9144/59/3/479chronic liver diseaseliver fibrosisultrasound elastographydynamic liver scintigraphy99mTc-mebrofenin |
| spellingShingle | Donatas Jocius Donatas Vajauskas Artūras Samuilis Kipras Mikelis Skirmante Jokubauskiene Kestutis Strupas Algirdas E. Tamosiunas Assessing Liver Fibrosis Using 2D-SWE Liver Ultrasound Elastography and Dynamic Liver Scintigraphy with 99mTc-mebrofenin: A Comparative Prospective Single-Center Study Medicina chronic liver disease liver fibrosis ultrasound elastography dynamic liver scintigraphy 99mTc-mebrofenin |
| title | Assessing Liver Fibrosis Using 2D-SWE Liver Ultrasound Elastography and Dynamic Liver Scintigraphy with 99mTc-mebrofenin: A Comparative Prospective Single-Center Study |
| title_full | Assessing Liver Fibrosis Using 2D-SWE Liver Ultrasound Elastography and Dynamic Liver Scintigraphy with 99mTc-mebrofenin: A Comparative Prospective Single-Center Study |
| title_fullStr | Assessing Liver Fibrosis Using 2D-SWE Liver Ultrasound Elastography and Dynamic Liver Scintigraphy with 99mTc-mebrofenin: A Comparative Prospective Single-Center Study |
| title_full_unstemmed | Assessing Liver Fibrosis Using 2D-SWE Liver Ultrasound Elastography and Dynamic Liver Scintigraphy with 99mTc-mebrofenin: A Comparative Prospective Single-Center Study |
| title_short | Assessing Liver Fibrosis Using 2D-SWE Liver Ultrasound Elastography and Dynamic Liver Scintigraphy with 99mTc-mebrofenin: A Comparative Prospective Single-Center Study |
| title_sort | assessing liver fibrosis using 2d swe liver ultrasound elastography and dynamic liver scintigraphy with 99mtc mebrofenin a comparative prospective single center study |
| topic | chronic liver disease liver fibrosis ultrasound elastography dynamic liver scintigraphy 99mTc-mebrofenin |
| url | https://www.mdpi.com/1648-9144/59/3/479 |
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