Non-Enzymatic Formation of <i>N</i>-acetylated Amino Acid Conjugates in Urine

Non-Enzymatic Formation of <i>N</i>-acetylated Amino Acid Conjugates in Urine

Unknown <i>N</i>-acylated amino acid (<i>N</i>-AAA) conjugates have been detected in maple syrup urine disease (MSUD) and other inborn errors of metabolism (IEMs). This study aimed to elucidate the mechanism behind the formation of urinary <i>N</i>-AAA conjugates....

Full description

Bibliographic Details
Main Authors: Jano Jacobs, Cornelia Gertina Catharina Elizabeth van Sittert, Lodewyk Japie Mienie, Marli Dercksen, Monique Opperman, Barend Christiaan Vorster
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Applied Sciences
Subjects:
<i>N</i>-acylated amino acid conjugates
non-enzymatic reactions
maple syrup urine disease
inborn errors of metabolism
racemic resolution
density functional theory (DFT)
Online Access:https://www.mdpi.com/2076-3417/13/18/10002

Similar Items

Similar Items