TAMs and PD-1 Networking in Gastric Cancer: A Review of the Literature
Background: Gastric cancer (GC) is one of the most common and aggressive types of cancer. Immune checkpoint inhibitors (ICIs) have proven effective in treating various types of cancer. The use of ICIs in GC patients is currently an area of ongoing research. The tumor microenvironment (TME) also seem...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/1/196 |
| _version_ | 1797359029396176896 |
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| author | Melina Yerolatsite Nanteznta Torounidou Aristeidis Gogadis Fani Kapoulitsa Panagiotis Ntellas Evangeli Lampri Maria Tolia Anna Batistatou Konstantinos Katsanos Davide Mauri |
| author_facet | Melina Yerolatsite Nanteznta Torounidou Aristeidis Gogadis Fani Kapoulitsa Panagiotis Ntellas Evangeli Lampri Maria Tolia Anna Batistatou Konstantinos Katsanos Davide Mauri |
| author_sort | Melina Yerolatsite |
| collection | DOAJ |
| description | Background: Gastric cancer (GC) is one of the most common and aggressive types of cancer. Immune checkpoint inhibitors (ICIs) have proven effective in treating various types of cancer. The use of ICIs in GC patients is currently an area of ongoing research. The tumor microenvironment (TME) also seems to play a crucial role in cancer progression. Tumor-associated macrophages (TAMs) are the most abundant population in the TME. TAMs are capable of displaying programmed cell death protein 1 (PD-1) on their surface and can form a ligand with programmed death ligand 1 (PD-L1), which is found on the surface of cancer cells. Therefore, it is expected that TAMs may significantly influence the immune response related to immune checkpoint inhibitors (ICIs). Aim of the study: Understanding the role of TAMs and PD-1/PD-L1 networking in GC. Methods: A systematic review of published data was performed using MEDLINE (PubMed), Embase, and Cochrane databases. We retrieved articles investigating the co-existence of TAMs and PD-1 in GC and the prognosis of patients expressing high levels of PD-1+ TAMs. Results: Ten articles with a total of 2277 patients were included in the systematic review. The examined data suggest that the expression of PD-L1 has a positive correlation with the infiltration of TAMs and that patients who express high levels of PD-1+ TAMs may have a worse prognosis than those who express low levels of PD-1+ TAMs. Conclusions: TAMs play a pivotal role in the regulation of PD-1/PD-L1 networking and the progression of GC cells. Nevertheless, additional studies are needed to better define the role of TAMs and PD-1/PD-L1 networking in GC. |
| first_indexed | 2024-03-08T15:10:46Z |
| format | Article |
| id | doaj.art-cfc6255f53ca4d0e8c98d0ea04a37b9d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T15:10:46Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-cfc6255f53ca4d0e8c98d0ea04a37b9d2024-01-10T14:53:00ZengMDPI AGCancers2072-66942023-12-0116119610.3390/cancers16010196TAMs and PD-1 Networking in Gastric Cancer: A Review of the LiteratureMelina Yerolatsite0Nanteznta Torounidou1Aristeidis Gogadis2Fani Kapoulitsa3Panagiotis Ntellas4Evangeli Lampri5Maria Tolia6Anna Batistatou7Konstantinos Katsanos8Davide Mauri9Department of Medical Oncology, University of Ioannina, 45500 Ioannina, GreeceDepartment of Medical Oncology, University of Ioannina, 45500 Ioannina, GreeceDepartment of Medical Oncology, University of Ioannina, 45500 Ioannina, GreeceDepartment of Medical Oncology, University of Ioannina, 45500 Ioannina, GreeceDepartment of Medical Oncology, University of Ioannina, 45500 Ioannina, GreeceDepartment of Pathology, University of Ioannina, 45500 Ioannina, GreeceDepartment of Radiotherapy, University of Crete, 71003 Heraklion, GreeceDepartment of Pathology, University of Ioannina, 45500 Ioannina, GreeceDepartment of Gastroenterology, University of Ioannina, 45500 Ioannina, GreeceDepartment of Medical Oncology, University of Ioannina, 45500 Ioannina, GreeceBackground: Gastric cancer (GC) is one of the most common and aggressive types of cancer. Immune checkpoint inhibitors (ICIs) have proven effective in treating various types of cancer. The use of ICIs in GC patients is currently an area of ongoing research. The tumor microenvironment (TME) also seems to play a crucial role in cancer progression. Tumor-associated macrophages (TAMs) are the most abundant population in the TME. TAMs are capable of displaying programmed cell death protein 1 (PD-1) on their surface and can form a ligand with programmed death ligand 1 (PD-L1), which is found on the surface of cancer cells. Therefore, it is expected that TAMs may significantly influence the immune response related to immune checkpoint inhibitors (ICIs). Aim of the study: Understanding the role of TAMs and PD-1/PD-L1 networking in GC. Methods: A systematic review of published data was performed using MEDLINE (PubMed), Embase, and Cochrane databases. We retrieved articles investigating the co-existence of TAMs and PD-1 in GC and the prognosis of patients expressing high levels of PD-1+ TAMs. Results: Ten articles with a total of 2277 patients were included in the systematic review. The examined data suggest that the expression of PD-L1 has a positive correlation with the infiltration of TAMs and that patients who express high levels of PD-1+ TAMs may have a worse prognosis than those who express low levels of PD-1+ TAMs. Conclusions: TAMs play a pivotal role in the regulation of PD-1/PD-L1 networking and the progression of GC cells. Nevertheless, additional studies are needed to better define the role of TAMs and PD-1/PD-L1 networking in GC.https://www.mdpi.com/2072-6694/16/1/196tumor microenvironment (TME)tumor-associated macrophages (TAMs)immune checkpoint inhibitors (ICIs)PD-1/PD-L1gastric cancer |
| spellingShingle | Melina Yerolatsite Nanteznta Torounidou Aristeidis Gogadis Fani Kapoulitsa Panagiotis Ntellas Evangeli Lampri Maria Tolia Anna Batistatou Konstantinos Katsanos Davide Mauri TAMs and PD-1 Networking in Gastric Cancer: A Review of the Literature Cancers tumor microenvironment (TME) tumor-associated macrophages (TAMs) immune checkpoint inhibitors (ICIs) PD-1/PD-L1 gastric cancer |
| title | TAMs and PD-1 Networking in Gastric Cancer: A Review of the Literature |
| title_full | TAMs and PD-1 Networking in Gastric Cancer: A Review of the Literature |
| title_fullStr | TAMs and PD-1 Networking in Gastric Cancer: A Review of the Literature |
| title_full_unstemmed | TAMs and PD-1 Networking in Gastric Cancer: A Review of the Literature |
| title_short | TAMs and PD-1 Networking in Gastric Cancer: A Review of the Literature |
| title_sort | tams and pd 1 networking in gastric cancer a review of the literature |
| topic | tumor microenvironment (TME) tumor-associated macrophages (TAMs) immune checkpoint inhibitors (ICIs) PD-1/PD-L1 gastric cancer |
| url | https://www.mdpi.com/2072-6694/16/1/196 |
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