Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study
Background: Hepatitis B virus (HBV) vaccination is mandatory among health care workers due to high risk of exposure to infection. However, the long-term protective effect of HBV vaccine and assessment of HBV vaccination status by measuring HBsAb remain questionable. Aim: assess the protective level...
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| Format: | Article |
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Zagazig University, Faculty of Medicine
2023-11-01
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| Series: | Microbes and Infectious Diseases |
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| Online Access: | https://mid.journals.ekb.eg/article_319615_9ef692f03cec0a974cf7e4ddb4e29ba3.pdf |
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| author | Mohamed Hashem Hanan Abdel-Haleem Marwa khairy Ayatallah Nassef Mahmoud Essam Eldin Eman D. El Desouky |
| author_facet | Mohamed Hashem Hanan Abdel-Haleem Marwa khairy Ayatallah Nassef Mahmoud Essam Eldin Eman D. El Desouky |
| author_sort | Mohamed Hashem |
| collection | DOAJ |
| description | Background: Hepatitis B virus (HBV) vaccination is mandatory among health care workers due to high risk of exposure to infection. However, the long-term protective effect of HBV vaccine and assessment of HBV vaccination status by measuring HBsAb remain questionable. Aim: assess the protective levels of anti-HBsAb among previously vaccinated medical residents and its relation to duration and doses of vaccine. Methods: Cross section study conducted on 202 residents working in Kasr Al-Aini Medical hospital (single center) HBV vaccinated. Serum HBsAb titer was tested using Elecsys® Anti-HBs II reagent by automated COBAS device system e-601. The residents were classified according to their protective antibody titer into three groups; negative protective titer (< 10IU/L), positive low protective titer (10-100 IU/L) and high positive protective titer (> 100 IU/L) groups. Results: Only 9.4% had negative protective titer, 35.15% had positive low protective titer and 55.45% had positive high protective titer. Negative protective HBsAb titer was significantly higher in males (15.5%), smokers (26.5%), with incomplete vaccination schedule (26.6%), compulsory vaccinated (53%) and last vaccine dose >10years (60.7%). Multivariate logistic regression analysis revealed that the duration since last vaccination dose (<10years) and completion of vaccination schedule (≥3doses) are the significant independent factors for HBsAb protective levels with p value <0.001 and 0.012. Conclusions: Protective anti-HBsAb level is related to the number of years elapsed since vaccination and the number of vaccine doses. |
| first_indexed | 2024-03-11T11:56:13Z |
| format | Article |
| id | doaj.art-cfc6430937c1442ab768345c61cca9ea |
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| issn | 2682-4132 2682-4140 |
| language | English |
| last_indexed | 2024-03-11T11:56:13Z |
| publishDate | 2023-11-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj.art-cfc6430937c1442ab768345c61cca9ea2023-11-08T19:05:38ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402023-11-01441133114110.21608/mid.2023.236668.1617319615Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center studyMohamed Hashem0Hanan Abdel-Haleem1Marwa khairy2Ayatallah Nassef3Mahmoud Essam Eldin4Eman D. El Desouky5Endemic Medicine and Hepatology Unit, Faculty of Medicine, Cairo University, EgyptEndemic Medicine and Hepatology Unit, Faculty of Medicine, Cairo University, EgyptEndemic Medicine and Hepatology Unit, Faculty of Medicine, Cairo University, EgyptClinical Pathology Department, Faculty of Medicine, Cairo University, EgyptEndemic Medicine and Hepatology Unit, Faculty of Medicine, Cairo University, EgyptEpidemiology and Biostatistics, National Cancer Institute, Cairo University, EgyptBackground: Hepatitis B virus (HBV) vaccination is mandatory among health care workers due to high risk of exposure to infection. However, the long-term protective effect of HBV vaccine and assessment of HBV vaccination status by measuring HBsAb remain questionable. Aim: assess the protective levels of anti-HBsAb among previously vaccinated medical residents and its relation to duration and doses of vaccine. Methods: Cross section study conducted on 202 residents working in Kasr Al-Aini Medical hospital (single center) HBV vaccinated. Serum HBsAb titer was tested using Elecsys® Anti-HBs II reagent by automated COBAS device system e-601. The residents were classified according to their protective antibody titer into three groups; negative protective titer (< 10IU/L), positive low protective titer (10-100 IU/L) and high positive protective titer (> 100 IU/L) groups. Results: Only 9.4% had negative protective titer, 35.15% had positive low protective titer and 55.45% had positive high protective titer. Negative protective HBsAb titer was significantly higher in males (15.5%), smokers (26.5%), with incomplete vaccination schedule (26.6%), compulsory vaccinated (53%) and last vaccine dose >10years (60.7%). Multivariate logistic regression analysis revealed that the duration since last vaccination dose (<10years) and completion of vaccination schedule (≥3doses) are the significant independent factors for HBsAb protective levels with p value <0.001 and 0.012. Conclusions: Protective anti-HBsAb level is related to the number of years elapsed since vaccination and the number of vaccine doses.https://mid.journals.ekb.eg/article_319615_9ef692f03cec0a974cf7e4ddb4e29ba3.pdfhbvhbsab titervaccineprotective titer |
| spellingShingle | Mohamed Hashem Hanan Abdel-Haleem Marwa khairy Ayatallah Nassef Mahmoud Essam Eldin Eman D. El Desouky Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study Microbes and Infectious Diseases hbv hbsab titer vaccine protective titer |
| title | Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study |
| title_full | Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study |
| title_fullStr | Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study |
| title_full_unstemmed | Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study |
| title_short | Assessment of protective serum anti-HBsAb levels among previously HBV vaccinated medical residents and its relation to duration and doses of vaccine – single center study |
| title_sort | assessment of protective serum anti hbsab levels among previously hbv vaccinated medical residents and its relation to duration and doses of vaccine single center study |
| topic | hbv hbsab titer vaccine protective titer |
| url | https://mid.journals.ekb.eg/article_319615_9ef692f03cec0a974cf7e4ddb4e29ba3.pdf |
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