The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
The Grb2 splice variant Grb3-3 results in decreased activation of the Ras-MAPK pathway due competition with Grb2 for SOS binding, with reduced Grb3-3 levels observed in tumour tissue suggestive of a mechanism for enhancing Ras pathway activity.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03985-7 |
| _version_ | 1811236393561620480 |
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| author | Caroline Seiler Amy K. Stainthorp Sophie Ketchen Christopher M. Jones Kate Marks Philip Quirke John E. Ladbury |
| author_facet | Caroline Seiler Amy K. Stainthorp Sophie Ketchen Christopher M. Jones Kate Marks Philip Quirke John E. Ladbury |
| author_sort | Caroline Seiler |
| collection | DOAJ |
| description | The Grb2 splice variant Grb3-3 results in decreased activation of the Ras-MAPK pathway due competition with Grb2 for SOS binding, with reduced Grb3-3 levels observed in tumour tissue suggestive of a mechanism for enhancing Ras pathway activity. |
| first_indexed | 2024-04-12T12:09:31Z |
| format | Article |
| id | doaj.art-cfc96b6f633f437e925d3d36fc562c13 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-12T12:09:31Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-cfc96b6f633f437e925d3d36fc562c132022-12-22T03:33:38ZengNature PortfolioCommunications Biology2399-36422022-09-015111210.1038/s42003-022-03985-7The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activationCaroline Seiler0Amy K. Stainthorp1Sophie Ketchen2Christopher M. Jones3Kate Marks4Philip Quirke5John E. Ladbury6School of Molecular and Cellular Biology, University of LeedsSchool of Molecular and Cellular Biology, University of LeedsSchool of Molecular and Cellular Biology, University of LeedsSchool of Molecular and Cellular Biology, University of LeedsUniversity of Leeds School of Medicine, Leeds Institute of Medical Research, Pathology and Data Analytics, University of LeedsUniversity of Leeds School of Medicine, Leeds Institute of Medical Research, Pathology and Data Analytics, University of LeedsSchool of Molecular and Cellular Biology, University of LeedsThe Grb2 splice variant Grb3-3 results in decreased activation of the Ras-MAPK pathway due competition with Grb2 for SOS binding, with reduced Grb3-3 levels observed in tumour tissue suggestive of a mechanism for enhancing Ras pathway activity.https://doi.org/10.1038/s42003-022-03985-7 |
| spellingShingle | Caroline Seiler Amy K. Stainthorp Sophie Ketchen Christopher M. Jones Kate Marks Philip Quirke John E. Ladbury The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation Communications Biology |
| title | The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation |
| title_full | The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation |
| title_fullStr | The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation |
| title_full_unstemmed | The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation |
| title_short | The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation |
| title_sort | grb2 splice variant grb3 3 is a negative regulator of ras activation |
| url | https://doi.org/10.1038/s42003-022-03985-7 |
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