Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in Korea
Background : : Acute complications within 100 days after allogeneic hematopoietic stem cell transplantation (HSCT) can increase immediate mortality as well as the risk of chronic complications and morbidity. A comprehensive review collecting systemic complications following transplantation would be...
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| Format: | Article |
| Language: | English |
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The Korean Society of Pediatric Hematology-Oncology
2023-04-01
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| Series: | Clinical Pediatric Hematology-Oncology |
| Subjects: | |
| Online Access: | http://www.cpho.or.kr/journal/view.html?doi=10.15264/cpho.2023.30.1.11 |
| _version_ | 1797837669818957824 |
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| author | Kyoung Min Lee Won Ki Ahn Jung Woo Han Chuhl Joo Lyu Seung Min Hahn |
| author_facet | Kyoung Min Lee Won Ki Ahn Jung Woo Han Chuhl Joo Lyu Seung Min Hahn |
| author_sort | Kyoung Min Lee |
| collection | DOAJ |
| description | Background : : Acute complications within 100 days after allogeneic hematopoietic stem cell transplantation (HSCT) can increase immediate mortality as well as the risk of chronic complications and morbidity. A comprehensive review collecting systemic complications following transplantation would be important in pediatric patients. <br />Methods : : We report a retrospective study of pediatric patients who underwent allogeneic HSCT during the 11 years (2009-2020), and their acute complications after transplantation within 100 days. A total 227 pediatric patients' (90 females, 137 males) data were collected. <br />Results : : Among the patients, 62.6% (N=142) suffered from acute graft-versus-host disease, and 118 (52.0%) patients had an acute infection. Pulmonary complications occurred in 52 (22.9%) patients followed by hepatic sinusoidal obstruction syndrome in 30 (18.1%) patients. In the study, 19 died within the first 100 days after HSCT (8.4%), and the 5-year overall survival rate of the patients was 65.4%. <br />Conclusion : : This study widens the understanding of acute toxicities of pediatric HSCT. A significant number of children still have experienced a variety of acute infectious or non-infectious complications after allogeneic HSCT that contribute to morbidity and mortality. Therefore, continuous efforts are needed to reduce them. |
| first_indexed | 2024-04-09T15:29:27Z |
| format | Article |
| id | doaj.art-cfcc18d1a91540c7a516671c2bb6b56d |
| institution | Directory Open Access Journal |
| issn | 2233-5250 |
| language | English |
| last_indexed | 2024-04-09T15:29:27Z |
| publishDate | 2023-04-01 |
| publisher | The Korean Society of Pediatric Hematology-Oncology |
| record_format | Article |
| series | Clinical Pediatric Hematology-Oncology |
| spelling | doaj.art-cfcc18d1a91540c7a516671c2bb6b56d2023-04-28T09:52:41ZengThe Korean Society of Pediatric Hematology-OncologyClinical Pediatric Hematology-Oncology2233-52502023-04-01301112010.15264/cpho.2023.30.1.11cpho.2023.30.1.11Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in KoreaKyoung Min Lee0Won Ki Ahn1Jung Woo Han2Chuhl Joo Lyu3Seung Min Hahn4Division of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, KoreaDivision of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, KoreaDivision of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, KoreaDivision of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, KoreaDivision of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, KoreaBackground : : Acute complications within 100 days after allogeneic hematopoietic stem cell transplantation (HSCT) can increase immediate mortality as well as the risk of chronic complications and morbidity. A comprehensive review collecting systemic complications following transplantation would be important in pediatric patients. <br />Methods : : We report a retrospective study of pediatric patients who underwent allogeneic HSCT during the 11 years (2009-2020), and their acute complications after transplantation within 100 days. A total 227 pediatric patients' (90 females, 137 males) data were collected. <br />Results : : Among the patients, 62.6% (N=142) suffered from acute graft-versus-host disease, and 118 (52.0%) patients had an acute infection. Pulmonary complications occurred in 52 (22.9%) patients followed by hepatic sinusoidal obstruction syndrome in 30 (18.1%) patients. In the study, 19 died within the first 100 days after HSCT (8.4%), and the 5-year overall survival rate of the patients was 65.4%. <br />Conclusion : : This study widens the understanding of acute toxicities of pediatric HSCT. A significant number of children still have experienced a variety of acute infectious or non-infectious complications after allogeneic HSCT that contribute to morbidity and mortality. Therefore, continuous efforts are needed to reduce them.http://www.cpho.or.kr/journal/view.html?doi=10.15264/cpho.2023.30.1.11hematopoietic stem cell transplantationpediatricgraft versus host diseaseinfection |
| spellingShingle | Kyoung Min Lee Won Ki Ahn Jung Woo Han Chuhl Joo Lyu Seung Min Hahn Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in Korea Clinical Pediatric Hematology-Oncology hematopoietic stem cell transplantation pediatric graft versus host disease infection |
| title | Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in Korea |
| title_full | Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in Korea |
| title_fullStr | Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in Korea |
| title_full_unstemmed | Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in Korea |
| title_short | Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in Korea |
| title_sort | acute complications of pediatric allogeneic hematopoietic stem cell transplantation and their effects on survival a single center experience in korea |
| topic | hematopoietic stem cell transplantation pediatric graft versus host disease infection |
| url | http://www.cpho.or.kr/journal/view.html?doi=10.15264/cpho.2023.30.1.11 |
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