Gene Therapy Strategy for Alzheimer’s and Parkinson’s Diseases Aimed at Preventing the Formation of Neurotoxic Oligomers in SH-SY5Y Cells

Gene Therapy Strategy for Alzheimer’s and Parkinson’s Diseases Aimed at Preventing the Formation of Neurotoxic Oligomers in SH-SY5Y Cells

We present here a gene therapy approach aimed at preventing the formation of Ca<sup>2+</sup>-permeable amyloid pore oligomers that are considered as the most neurotoxic structures in both Alzheimer’s and Parkinson’s diseases. Our study is based on the design of a small peptide inhibitor...

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Bibliographic Details
Main Authors:	Assou El-Battari, Léa Rodriguez, Henri Chahinian, Olivier Delézay, Jacques Fantini, Nouara Yahi, Coralie Di Scala
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Series:	International Journal of Molecular Sciences
Subjects:	amyloid proteins oligomeric pores calcium gangliosides
Online Access:	https://www.mdpi.com/1422-0067/22/21/11550

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