Giant cell tumor of soft tissue of the colon: a case report and review of the literature
Abstract Background A giant cell tumor (GCT) is a benign neoplasm characterized by mixture of mononuclear cells and multinucleated cells. A GCT of soft tissue (GCT-ST) is developed in various extraosseous sites, but GCT-ST of the gastrointestinal tract is very rare. GCT-ST usually has a benign cours...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-022-02391-x |
| _version_ | 1818117217283211264 |
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| author | Seung Woo Lee Jun Lee Seong Jung Kim Ran Hong |
| author_facet | Seung Woo Lee Jun Lee Seong Jung Kim Ran Hong |
| author_sort | Seung Woo Lee |
| collection | DOAJ |
| description | Abstract Background A giant cell tumor (GCT) is a benign neoplasm characterized by mixture of mononuclear cells and multinucleated cells. A GCT of soft tissue (GCT-ST) is developed in various extraosseous sites, but GCT-ST of the gastrointestinal tract is very rare. GCT-ST usually has a benign course, but rare cases reported malignant potential of the tumor. Therefore, complete resection is required to prevent local recurrence or distant metastasis. Case presentation A 53-year-old woman was admitted for follow-up colonoscopy who underwent the colorectal endoscopic submucosal dissection (ESD) of a laterally spreading tumor at the hepatic flexure 6 months ago. A colonoscopy showed a polypoid mass about 3.5 × 2.5 cm at the previous ESD site. As endoscopic finding showed a smooth multi-nodular tumor without submucosal invasion, we performed endoscopic mucosal resection. Based on pathological and immunohistochemical findings, the lesion was diagnosed as a GCT-ST in the colon. Follow-up colonoscopy performed 6 months later revealed no evidence of recurrence. Conclusion This is the first report of a GCT-ST identified in the colon. Although GCT-ST generally has a benign clinical course, complete resection should be performed to prevent local recurrence and metastasis. |
| first_indexed | 2024-12-11T04:34:54Z |
| format | Article |
| id | doaj.art-cfcdd8d14c3d4d78acf6497dfde3b62c |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-11T04:34:54Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-cfcdd8d14c3d4d78acf6497dfde3b62c2022-12-22T01:20:46ZengBMCBMC Gastroenterology1471-230X2022-06-012211510.1186/s12876-022-02391-xGiant cell tumor of soft tissue of the colon: a case report and review of the literatureSeung Woo Lee0Jun Lee1Seong Jung Kim2Ran Hong3Department of Internal Medicine, College of Medicine, Chosun UniversityDepartment of Internal Medicine, College of Medicine, Chosun UniversityDepartment of Internal Medicine, College of Medicine, Chosun UniversityDepartment of Pathology, College of Medicine, Chosun UniversityAbstract Background A giant cell tumor (GCT) is a benign neoplasm characterized by mixture of mononuclear cells and multinucleated cells. A GCT of soft tissue (GCT-ST) is developed in various extraosseous sites, but GCT-ST of the gastrointestinal tract is very rare. GCT-ST usually has a benign course, but rare cases reported malignant potential of the tumor. Therefore, complete resection is required to prevent local recurrence or distant metastasis. Case presentation A 53-year-old woman was admitted for follow-up colonoscopy who underwent the colorectal endoscopic submucosal dissection (ESD) of a laterally spreading tumor at the hepatic flexure 6 months ago. A colonoscopy showed a polypoid mass about 3.5 × 2.5 cm at the previous ESD site. As endoscopic finding showed a smooth multi-nodular tumor without submucosal invasion, we performed endoscopic mucosal resection. Based on pathological and immunohistochemical findings, the lesion was diagnosed as a GCT-ST in the colon. Follow-up colonoscopy performed 6 months later revealed no evidence of recurrence. Conclusion This is the first report of a GCT-ST identified in the colon. Although GCT-ST generally has a benign clinical course, complete resection should be performed to prevent local recurrence and metastasis.https://doi.org/10.1186/s12876-022-02391-xGiant cell tumorsSoft tissue neoplasmEndoscopic mucosal resectionCase report |
| spellingShingle | Seung Woo Lee Jun Lee Seong Jung Kim Ran Hong Giant cell tumor of soft tissue of the colon: a case report and review of the literature BMC Gastroenterology Giant cell tumors Soft tissue neoplasm Endoscopic mucosal resection Case report |
| title | Giant cell tumor of soft tissue of the colon: a case report and review of the literature |
| title_full | Giant cell tumor of soft tissue of the colon: a case report and review of the literature |
| title_fullStr | Giant cell tumor of soft tissue of the colon: a case report and review of the literature |
| title_full_unstemmed | Giant cell tumor of soft tissue of the colon: a case report and review of the literature |
| title_short | Giant cell tumor of soft tissue of the colon: a case report and review of the literature |
| title_sort | giant cell tumor of soft tissue of the colon a case report and review of the literature |
| topic | Giant cell tumors Soft tissue neoplasm Endoscopic mucosal resection Case report |
| url | https://doi.org/10.1186/s12876-022-02391-x |
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