DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA
Objective: The purpose of this study was to evaluate the diagnostic utility of SATB2 in detecting CRC origin for patients presenting with metastatic carcinomas. Study Design: Cross sectional, comparative study. Place and Duration of Study: Study was conducted at department of Histopathology, A...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2021-01-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://pafmj.org/index.php/PAFMJ/article/view/3034 |
| _version_ | 1818422499331801088 |
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| author | Sammeen Salim Muhammad Asif Rabia Ahmed Hafeez Ud Din Muhammad Tahir Khadim Gazala Sadaf |
| author_facet | Sammeen Salim Muhammad Asif Rabia Ahmed Hafeez Ud Din Muhammad Tahir Khadim Gazala Sadaf |
| author_sort | Sammeen Salim |
| collection | DOAJ |
| description | Objective: The purpose of this study was to evaluate the diagnostic utility of SATB2 in detecting CRC origin for patients presenting with metastatic carcinomas.
Study Design: Cross sectional, comparative study.
Place and Duration of Study: Study was conducted at department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi from January 2019 to June 2019.
Materials and Methods: Already diagnosed 68 cases of metastatic carcinoma of various origins with unknown primary were retrieved from tumour registry. Paraffin embedded blocks were taken and a panel of Immunohistochemistry was applied which includes CK7, CK20,CDX2 and SATB2. Positivity of SATB2 alone, and combination of SATB2 with CK 7,CK20 and CDX2 was evaluated.
Results: Out of 68 metastatic adenocarcinoma cases 28(41%) had positive SATB2 expression and 38 (56%) were negative. All the positive SATB2 cases had 100 % (28/28) expression with CDX2, 93% (26/28) of the cases had expression with CK20 and 21% (6/28) of the cases showed expression of CK7. The sensitivity of SATB2 alone was 100% in metastatic colorectal carcinoma as compared to CK20 and CDX2. The sensitivity of SATB2 in combination with CDX2 (100%) and CK20 (93%)in comparison to the double combination of CK20 and CDX2(93 %). The sensitivity of SATB2 and CK20 combination was 93%, which was equal to CK20 and CDX2 combination.
Conclusions: Our results show that SATB2 is a sensitive marker in the IHC panel for cases with suspected metastasis from colorectal region. |
| first_indexed | 2024-12-14T13:27:13Z |
| format | Article |
| id | doaj.art-cfce15e25f2f4cbc8bfe7aa048114b5e |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-14T13:27:13Z |
| publishDate | 2021-01-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-cfce15e25f2f4cbc8bfe7aa048114b5e2022-12-21T22:59:48ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422021-01-0171SUPPL-13236https://doi.org/10.51253/pafmj.v71iSuppl-1.30343034DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMASammeen Salim0Muhammad Asif1Rabia Ahmed2Hafeez Ud Din3Muhammad Tahir Khadim4Gazala Sadaf5Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanObjective: The purpose of this study was to evaluate the diagnostic utility of SATB2 in detecting CRC origin for patients presenting with metastatic carcinomas. Study Design: Cross sectional, comparative study. Place and Duration of Study: Study was conducted at department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi from January 2019 to June 2019. Materials and Methods: Already diagnosed 68 cases of metastatic carcinoma of various origins with unknown primary were retrieved from tumour registry. Paraffin embedded blocks were taken and a panel of Immunohistochemistry was applied which includes CK7, CK20,CDX2 and SATB2. Positivity of SATB2 alone, and combination of SATB2 with CK 7,CK20 and CDX2 was evaluated. Results: Out of 68 metastatic adenocarcinoma cases 28(41%) had positive SATB2 expression and 38 (56%) were negative. All the positive SATB2 cases had 100 % (28/28) expression with CDX2, 93% (26/28) of the cases had expression with CK20 and 21% (6/28) of the cases showed expression of CK7. The sensitivity of SATB2 alone was 100% in metastatic colorectal carcinoma as compared to CK20 and CDX2. The sensitivity of SATB2 in combination with CDX2 (100%) and CK20 (93%)in comparison to the double combination of CK20 and CDX2(93 %). The sensitivity of SATB2 and CK20 combination was 93%, which was equal to CK20 and CDX2 combination. Conclusions: Our results show that SATB2 is a sensitive marker in the IHC panel for cases with suspected metastasis from colorectal region.https://pafmj.org/index.php/PAFMJ/article/view/3034cdx2ck7ck20mcrcsatb2 |
| spellingShingle | Sammeen Salim Muhammad Asif Rabia Ahmed Hafeez Ud Din Muhammad Tahir Khadim Gazala Sadaf DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA Pakistan Armed Forces Medical Journal cdx2 ck7 ck20 mcrc satb2 |
| title | DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA |
| title_full | DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA |
| title_fullStr | DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA |
| title_full_unstemmed | DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA |
| title_short | DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA |
| title_sort | diagnostic utility of satb2 in metastatic colorectal carcinoma |
| topic | cdx2 ck7 ck20 mcrc satb2 |
| url | https://pafmj.org/index.php/PAFMJ/article/view/3034 |
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