An Experimental Design Approach to Quantitative Expression for Quality Control of a Multicomponent Antidiabetic Formulation by the HILIC Method

An Experimental Design Approach to Quantitative Expression for Quality Control of a Multicomponent Antidiabetic Formulation by the HILIC Method

A rapid and reproducible hydrophilic liquid chromatography (HILIC) process was established for concomitant determination of remogliflozin etabonate (RE), vildagliptin (VD), and metformin (MF) in a formulation. A face-centered central composite experimental design was employed to optimize and predict...

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Bibliographic Details
Main Authors: Mahesh Attimarad, Katharigatta Narayanaswamy Venugopala, Muhammad S. Chohan, Marysheela David, Efren II Plaza Molina, Nagaraja Sreeharsha, Anroop Balachandran Nair, Christophe Tratrat, Abdulrahman Ibrahim Altaysan, Abdulmalek Ahmed Balgoname
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
quality by design
HILIC
chromatography
remogliflozin
vildagliptin
metformin
Online Access:https://www.mdpi.com/1420-3049/27/10/3135

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