The Value of Microbes in Cancer Neoantigen Immunotherapy
Tumor neoantigens are widely used in cancer immunotherapy, and a growing body of research suggests that microbes play an important role in these neoantigen-based immunotherapeutic processes. The human body and its surrounding environment are filled with a large number of microbes that are in long-te...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/8/2138 |
| _version_ | 1797583511446618112 |
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| author | Junrui Tian Jian Ma |
| author_facet | Junrui Tian Jian Ma |
| author_sort | Junrui Tian |
| collection | DOAJ |
| description | Tumor neoantigens are widely used in cancer immunotherapy, and a growing body of research suggests that microbes play an important role in these neoantigen-based immunotherapeutic processes. The human body and its surrounding environment are filled with a large number of microbes that are in long-term interaction with the organism. The microbiota can modulate our immune system, help activate neoantigen-reactive T cells, and play a great role in the process of targeting tumor neoantigens for therapy. Recent studies have revealed the interconnection between microbes and neoantigens, which can cross-react with each other through molecular mimicry, providing theoretical guidance for more relevant studies. The current applications of microbes in immunotherapy against tumor neoantigens are mainly focused on cancer vaccine development and immunotherapy with immune checkpoint inhibitors. This article summarizes the related fields and suggests the importance of microbes in immunotherapy against neoantigens. |
| first_indexed | 2024-03-10T23:39:57Z |
| format | Article |
| id | doaj.art-cfcf8b9cd3524d1c825ba57a45d81a8e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T23:39:57Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-cfcf8b9cd3524d1c825ba57a45d81a8e2023-11-19T02:37:26ZengMDPI AGPharmaceutics1999-49232023-08-01158213810.3390/pharmaceutics15082138The Value of Microbes in Cancer Neoantigen ImmunotherapyJunrui Tian0Jian Ma1NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, ChinaNHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, ChinaTumor neoantigens are widely used in cancer immunotherapy, and a growing body of research suggests that microbes play an important role in these neoantigen-based immunotherapeutic processes. The human body and its surrounding environment are filled with a large number of microbes that are in long-term interaction with the organism. The microbiota can modulate our immune system, help activate neoantigen-reactive T cells, and play a great role in the process of targeting tumor neoantigens for therapy. Recent studies have revealed the interconnection between microbes and neoantigens, which can cross-react with each other through molecular mimicry, providing theoretical guidance for more relevant studies. The current applications of microbes in immunotherapy against tumor neoantigens are mainly focused on cancer vaccine development and immunotherapy with immune checkpoint inhibitors. This article summarizes the related fields and suggests the importance of microbes in immunotherapy against neoantigens.https://www.mdpi.com/1999-4923/15/8/2138tumor neoantigencancer immunotherapymicrobescancer vaccinesimmune checkpoint inhibitors |
| spellingShingle | Junrui Tian Jian Ma The Value of Microbes in Cancer Neoantigen Immunotherapy Pharmaceutics tumor neoantigen cancer immunotherapy microbes cancer vaccines immune checkpoint inhibitors |
| title | The Value of Microbes in Cancer Neoantigen Immunotherapy |
| title_full | The Value of Microbes in Cancer Neoantigen Immunotherapy |
| title_fullStr | The Value of Microbes in Cancer Neoantigen Immunotherapy |
| title_full_unstemmed | The Value of Microbes in Cancer Neoantigen Immunotherapy |
| title_short | The Value of Microbes in Cancer Neoantigen Immunotherapy |
| title_sort | value of microbes in cancer neoantigen immunotherapy |
| topic | tumor neoantigen cancer immunotherapy microbes cancer vaccines immune checkpoint inhibitors |
| url | https://www.mdpi.com/1999-4923/15/8/2138 |
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