Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease
Background: Proteasome subunits (PSMB) and transporter associated with antigen processing (TAP) loci are located in the human leukocyte antigen (HLA) Class II region play important roles in immune response and protein degradation in neurodegenerative diseases. This study aimed to explore the associa...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2016-01-01
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| Series: | Chinese Medical Journal |
| Subjects: | |
| Online Access: | http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=9;spage=1053;epage=1058;aulast=Mo |
| _version_ | 1819146295864983552 |
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| author | Ming-Shu Mo Wei Huang Cong-Cong Sun Li-Min Zhang Luan Cen You-Sheng Xiao Guo-Fei Li Xin-Ling Yang Shao-Gang Qu Ping-Yi Xu |
| author_facet | Ming-Shu Mo Wei Huang Cong-Cong Sun Li-Min Zhang Luan Cen You-Sheng Xiao Guo-Fei Li Xin-Ling Yang Shao-Gang Qu Ping-Yi Xu |
| author_sort | Ming-Shu Mo |
| collection | DOAJ |
| description | Background: Proteasome subunits (PSMB) and transporter associated with antigen processing (TAP) loci are located in the human leukocyte antigen (HLA) Class II region play important roles in immune response and protein degradation in neurodegenerative diseases. This study aimed to explore the association between single nucleotide polymorphisms (SNPs) of PSMB and TAP and Parkinson's disease (PD).
Methods: A case–control study was conducted by genotyping SNPs in PSMB8, PSMB9, TAP1, and TAP2 genes in the Chinese population. Subjects included 542 sporadic patients with PD and 674 healthy controls. Nine identified SNPs in PSMB8, PSMB9, TAP1, and TAP2 were genotyped through SNaPshot testing.
Results: The stratified analysis of rs17587 was specially performed on gender. Data revealed that female patients carry a higher frequency of rs17587-G/G versus (A/A + G/A) compared with controls. But there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in PD patients.
Conclusion: Chinese females carrying the rs17587-G/G genotype in PSMB9 may increase a higher risk for PD, but no linkage was found between other SNPs in HLA Class II region and PD. |
| first_indexed | 2024-12-22T13:11:40Z |
| format | Article |
| id | doaj.art-cfd0b64a989f4c8dabf728ba03b93cf8 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 |
| language | English |
| last_indexed | 2024-12-22T13:11:40Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-cfd0b64a989f4c8dabf728ba03b93cf82022-12-21T18:24:44ZengWolters KluwerChinese Medical Journal0366-69992016-01-0112991053105810.4103/0366-6999.180513Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's DiseaseMing-Shu MoWei HuangCong-Cong SunLi-Min ZhangLuan CenYou-Sheng XiaoGuo-Fei LiXin-Ling YangShao-Gang QuPing-Yi XuBackground: Proteasome subunits (PSMB) and transporter associated with antigen processing (TAP) loci are located in the human leukocyte antigen (HLA) Class II region play important roles in immune response and protein degradation in neurodegenerative diseases. This study aimed to explore the association between single nucleotide polymorphisms (SNPs) of PSMB and TAP and Parkinson's disease (PD). Methods: A case–control study was conducted by genotyping SNPs in PSMB8, PSMB9, TAP1, and TAP2 genes in the Chinese population. Subjects included 542 sporadic patients with PD and 674 healthy controls. Nine identified SNPs in PSMB8, PSMB9, TAP1, and TAP2 were genotyped through SNaPshot testing. Results: The stratified analysis of rs17587 was specially performed on gender. Data revealed that female patients carry a higher frequency of rs17587-G/G versus (A/A + G/A) compared with controls. But there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in PD patients. Conclusion: Chinese females carrying the rs17587-G/G genotype in PSMB9 may increase a higher risk for PD, but no linkage was found between other SNPs in HLA Class II region and PD.http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=9;spage=1053;epage=1058;aulast=MoHan Chinese; Proteasome Subunit Beta Type; Sporadic Parkinson's Disease; TAP |
| spellingShingle | Ming-Shu Mo Wei Huang Cong-Cong Sun Li-Min Zhang Luan Cen You-Sheng Xiao Guo-Fei Li Xin-Ling Yang Shao-Gang Qu Ping-Yi Xu Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease Chinese Medical Journal Han Chinese; Proteasome Subunit Beta Type; Sporadic Parkinson's Disease; TAP |
| title | Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease |
| title_full | Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease |
| title_fullStr | Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease |
| title_full_unstemmed | Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease |
| title_short | Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease |
| title_sort | association analysis of proteasome subunits and transporter associated with antigen processing on chinese patients with parkinson s disease |
| topic | Han Chinese; Proteasome Subunit Beta Type; Sporadic Parkinson's Disease; TAP |
| url | http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=9;spage=1053;epage=1058;aulast=Mo |
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