Effects of alkali-metal ions on phospholipid and triglyceride synthesis in rat liver slices
The influence of alkali-metal ions on the incorporation of labeled precursors into phospholipids and triglycerides was studied in rat liver slices. By use of acetate-1-C14 and palmitate-1-C14 as lipid precursors, a comparison was made of the pathway from acetate to phospholipid and the pathway from...
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| Format: | Article |
| Language: | English |
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Elsevier
1965-01-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520396425 |
| _version_ | 1818328766763499520 |
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| author | R.S. Leal |
| author_facet | R.S. Leal |
| author_sort | R.S. Leal |
| collection | DOAJ |
| description | The influence of alkali-metal ions on the incorporation of labeled precursors into phospholipids and triglycerides was studied in rat liver slices. By use of acetate-1-C14 and palmitate-1-C14 as lipid precursors, a comparison was made of the pathway from acetate to phospholipid and the pathway from palmitate to phospholipid. While the rate of incorporation of palmitate-1-C14 into phospholipids and triglyceride fatty acids was virtually independent of the alkali-metal ion present in the medium, the rate of incorporation of acetate-1-C14 into the same compounds was strongly influenced by the alkali-metal ions, the highest incorporations being obtained with potassium and rubidium. Under the same conditions lithium appears to have an inhibitory effect. The effects of the alkali-metal ions on phospholipid and triglyceride synthesis in liver are located on the pathway between acetate and long-chain fatty acids. |
| first_indexed | 2024-12-13T12:37:23Z |
| format | Article |
| id | doaj.art-cfd2f4bab3234aa391ae0568bcf7d8c1 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-13T12:37:23Z |
| publishDate | 1965-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-cfd2f4bab3234aa391ae0568bcf7d8c12022-12-21T23:45:46ZengElsevierJournal of Lipid Research0022-22751965-01-01618083Effects of alkali-metal ions on phospholipid and triglyceride synthesis in rat liver slicesR.S. Leal0Instituto Bento da Rocha Cabral, Lisbon, PortugalThe influence of alkali-metal ions on the incorporation of labeled precursors into phospholipids and triglycerides was studied in rat liver slices. By use of acetate-1-C14 and palmitate-1-C14 as lipid precursors, a comparison was made of the pathway from acetate to phospholipid and the pathway from palmitate to phospholipid. While the rate of incorporation of palmitate-1-C14 into phospholipids and triglyceride fatty acids was virtually independent of the alkali-metal ion present in the medium, the rate of incorporation of acetate-1-C14 into the same compounds was strongly influenced by the alkali-metal ions, the highest incorporations being obtained with potassium and rubidium. Under the same conditions lithium appears to have an inhibitory effect. The effects of the alkali-metal ions on phospholipid and triglyceride synthesis in liver are located on the pathway between acetate and long-chain fatty acids.http://www.sciencedirect.com/science/article/pii/S0022227520396425fatty acid biosynthesisphospholipid biosynthesistriglyceride biosynthesisratliver slicesalkali-metal ions |
| spellingShingle | R.S. Leal Effects of alkali-metal ions on phospholipid and triglyceride synthesis in rat liver slices Journal of Lipid Research fatty acid biosynthesis phospholipid biosynthesis triglyceride biosynthesis rat liver slices alkali-metal ions |
| title | Effects of alkali-metal ions on phospholipid and triglyceride synthesis in rat liver slices |
| title_full | Effects of alkali-metal ions on phospholipid and triglyceride synthesis in rat liver slices |
| title_fullStr | Effects of alkali-metal ions on phospholipid and triglyceride synthesis in rat liver slices |
| title_full_unstemmed | Effects of alkali-metal ions on phospholipid and triglyceride synthesis in rat liver slices |
| title_short | Effects of alkali-metal ions on phospholipid and triglyceride synthesis in rat liver slices |
| title_sort | effects of alkali metal ions on phospholipid and triglyceride synthesis in rat liver slices |
| topic | fatty acid biosynthesis phospholipid biosynthesis triglyceride biosynthesis rat liver slices alkali-metal ions |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520396425 |
| work_keys_str_mv | AT rsleal effectsofalkalimetalionsonphospholipidandtriglyceridesynthesisinratliverslices |