Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review
Abstract The nanosystems for delivering drugs which have evolved with time, are being designed for greater drug efficiency and lesser side-effects, and are also complemented by the advancement of numerous innovative materials. In comparison to the organic nanoparticles, the inorganic nanoparticles a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2023-12-01
|
| Series: | Discover Nano |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11671-023-03943-0 |
| _version_ | 1797376870214270976 |
|---|---|
| author | Gayathri Unnikrishnan Anjumol Joy M. Megha Elayaraja Kolanthai M. Senthilkumar |
| author_facet | Gayathri Unnikrishnan Anjumol Joy M. Megha Elayaraja Kolanthai M. Senthilkumar |
| author_sort | Gayathri Unnikrishnan |
| collection | DOAJ |
| description | Abstract The nanosystems for delivering drugs which have evolved with time, are being designed for greater drug efficiency and lesser side-effects, and are also complemented by the advancement of numerous innovative materials. In comparison to the organic nanoparticles, the inorganic nanoparticles are stable, have a wide range of physicochemical, mechanical, magnetic, and optical characteristics, and also have the capability to get modified using some ligands to enrich their attraction towards the molecules at the target site, which makes them appealing for bio-imaging and drug delivery applications. One of the strong benefits of using the inorganic nanoparticles-drug conjugate is the possibility of delivering the drugs to the affected cells locally, thus reducing the side-effects like cytotoxicity, and facilitating a higher efficacy of the therapeutic drug. This review features the direct and indirect effects of such inorganic nanoparticles like gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, and CeO2 nanoparticles in developing effective drug carrier systems. This article has remarked the peculiarities of these nanoparticle-based systems in pulmonary, ocular, wound healing, and antibacterial drug deliveries as well as in delivering drugs across Blood–Brain-Barrier (BBB) and acting as agents for cancer theranostics. Additionally, the article sheds light on the plausible modifications that can be carried out on the inorganic nanoparticles, from a researcher’s perspective, which could open a new pathway. Graphical abstract |
| first_indexed | 2024-03-08T19:44:49Z |
| format | Article |
| id | doaj.art-cfd2f71a91484ef6a364e2962eb44995 |
| institution | Directory Open Access Journal |
| issn | 2731-9229 |
| language | English |
| last_indexed | 2024-03-08T19:44:49Z |
| publishDate | 2023-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Nano |
| spelling | doaj.art-cfd2f71a91484ef6a364e2962eb449952023-12-24T12:26:59ZengSpringerDiscover Nano2731-92292023-12-0118114410.1186/s11671-023-03943-0Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical reviewGayathri Unnikrishnan0Anjumol Joy1M. Megha2Elayaraja Kolanthai3M. Senthilkumar4Department of Physics, Karunya Institute of Technology and SciencesDepartment of Physics, Karunya Institute of Technology and SciencesDepartment of Physics, Karunya Institute of Technology and SciencesDepartment of Materials Sciences and Engineering, Advanced Materials Processing and Analysis Centre, University of Central FloridaDepartment of Physics, Karunya Institute of Technology and SciencesAbstract The nanosystems for delivering drugs which have evolved with time, are being designed for greater drug efficiency and lesser side-effects, and are also complemented by the advancement of numerous innovative materials. In comparison to the organic nanoparticles, the inorganic nanoparticles are stable, have a wide range of physicochemical, mechanical, magnetic, and optical characteristics, and also have the capability to get modified using some ligands to enrich their attraction towards the molecules at the target site, which makes them appealing for bio-imaging and drug delivery applications. One of the strong benefits of using the inorganic nanoparticles-drug conjugate is the possibility of delivering the drugs to the affected cells locally, thus reducing the side-effects like cytotoxicity, and facilitating a higher efficacy of the therapeutic drug. This review features the direct and indirect effects of such inorganic nanoparticles like gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, and CeO2 nanoparticles in developing effective drug carrier systems. This article has remarked the peculiarities of these nanoparticle-based systems in pulmonary, ocular, wound healing, and antibacterial drug deliveries as well as in delivering drugs across Blood–Brain-Barrier (BBB) and acting as agents for cancer theranostics. Additionally, the article sheds light on the plausible modifications that can be carried out on the inorganic nanoparticles, from a researcher’s perspective, which could open a new pathway. Graphical abstracthttps://doi.org/10.1186/s11671-023-03943-0Inorganic nanoparticlesDrug deliveryBlood–brain-barrierTheranosticsWound healing |
| spellingShingle | Gayathri Unnikrishnan Anjumol Joy M. Megha Elayaraja Kolanthai M. Senthilkumar Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review Discover Nano Inorganic nanoparticles Drug delivery Blood–brain-barrier Theranostics Wound healing |
| title | Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review |
| title_full | Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review |
| title_fullStr | Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review |
| title_full_unstemmed | Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review |
| title_short | Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review |
| title_sort | exploration of inorganic nanoparticles for revolutionary drug delivery applications a critical review |
| topic | Inorganic nanoparticles Drug delivery Blood–brain-barrier Theranostics Wound healing |
| url | https://doi.org/10.1186/s11671-023-03943-0 |
| work_keys_str_mv | AT gayathriunnikrishnan explorationofinorganicnanoparticlesforrevolutionarydrugdeliveryapplicationsacriticalreview AT anjumoljoy explorationofinorganicnanoparticlesforrevolutionarydrugdeliveryapplicationsacriticalreview AT mmegha explorationofinorganicnanoparticlesforrevolutionarydrugdeliveryapplicationsacriticalreview AT elayarajakolanthai explorationofinorganicnanoparticlesforrevolutionarydrugdeliveryapplicationsacriticalreview AT msenthilkumar explorationofinorganicnanoparticlesforrevolutionarydrugdeliveryapplicationsacriticalreview |