Current therapies for lowering lipoprotein (a)
Lipoprotein (a) [Lp(a)] is a human plasma lipoprotein with unique structural and functional characteristics. Lp(a) is an assembly of two components: a central core with apoB and an additional glycoprotein, called apo(a). Ever since the strong association between elevated levels of Lp(a) and an incre...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520309299 |
| _version_ | 1818957122584444928 |
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| author | Julian C. van Capelleveen Fleur M. van der Valk ErikS.G. Stroes |
| author_facet | Julian C. van Capelleveen Fleur M. van der Valk ErikS.G. Stroes |
| author_sort | Julian C. van Capelleveen |
| collection | DOAJ |
| description | Lipoprotein (a) [Lp(a)] is a human plasma lipoprotein with unique structural and functional characteristics. Lp(a) is an assembly of two components: a central core with apoB and an additional glycoprotein, called apo(a). Ever since the strong association between elevated levels of Lp(a) and an increased risk for CVD was recognized, interest in the therapeutic modulation of Lp(a) levels has increased. Here, the past and present therapies aiming to lower Lp(a) levels will be reviewed, demonstrating that these agents have had varying degrees of success. The next challenge will be to prove that Lp(a) lowering also leads to cardiovascular benefit in patients with elevated Lp(a) levels. Therefore, highly specific and potent Lp(a)-lowering strategies are awaited urgently. |
| first_indexed | 2024-12-20T11:04:50Z |
| format | Article |
| id | doaj.art-cfd332c59ef84ecdba3093b30a155a2d |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-20T11:04:50Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-cfd332c59ef84ecdba3093b30a155a2d2022-12-21T19:42:54ZengElsevierJournal of Lipid Research0022-22752016-09-0157916121618Current therapies for lowering lipoprotein (a)Julian C. van Capelleveen0Fleur M. van der Valk1ErikS.G. Stroes2Department of Vascular Medicine, Academic Medical Center, Amsterdam, The NetherlandsDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, The NetherlandsTo whom correspondence should be addressed; Department of Vascular Medicine, Academic Medical Center, Amsterdam, The NetherlandsLipoprotein (a) [Lp(a)] is a human plasma lipoprotein with unique structural and functional characteristics. Lp(a) is an assembly of two components: a central core with apoB and an additional glycoprotein, called apo(a). Ever since the strong association between elevated levels of Lp(a) and an increased risk for CVD was recognized, interest in the therapeutic modulation of Lp(a) levels has increased. Here, the past and present therapies aiming to lower Lp(a) levels will be reviewed, demonstrating that these agents have had varying degrees of success. The next challenge will be to prove that Lp(a) lowering also leads to cardiovascular benefit in patients with elevated Lp(a) levels. Therefore, highly specific and potent Lp(a)-lowering strategies are awaited urgently.http://www.sciencedirect.com/science/article/pii/S0022227520309299apolipoproteinsdrug therapydrug therapy/hypolipidemic drugsdyslipidemiaslipoproteinslipoprotein(a) |
| spellingShingle | Julian C. van Capelleveen Fleur M. van der Valk ErikS.G. Stroes Current therapies for lowering lipoprotein (a) Journal of Lipid Research apolipoproteins drug therapy drug therapy/hypolipidemic drugs dyslipidemias lipoproteins lipoprotein(a) |
| title | Current therapies for lowering lipoprotein (a) |
| title_full | Current therapies for lowering lipoprotein (a) |
| title_fullStr | Current therapies for lowering lipoprotein (a) |
| title_full_unstemmed | Current therapies for lowering lipoprotein (a) |
| title_short | Current therapies for lowering lipoprotein (a) |
| title_sort | current therapies for lowering lipoprotein a |
| topic | apolipoproteins drug therapy drug therapy/hypolipidemic drugs dyslipidemias lipoproteins lipoprotein(a) |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520309299 |
| work_keys_str_mv | AT juliancvancapelleveen currenttherapiesforloweringlipoproteina AT fleurmvandervalk currenttherapiesforloweringlipoproteina AT eriksgstroes currenttherapiesforloweringlipoproteina |