Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study
Antioxidants are privileged candidates for the development of adjuvants able to improve the efficiency of pharmacological therapies, particularly for chronic inflammatory syndromes. During the last 20 years, anti-TNFα (tumor necrosis factor alpha) monoclonal antibodies infusion has been the biologic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/1/138 |
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| author | Marina Liso Annamaria Sila Giulio Verna Aurelia Scarano Rossella Donghia Fabio Castellana Elisabetta Cavalcanti Pasqua Letizia Pesole Eduardo Maria Sommella Antonio Lippolis Raffaele Armentano Anna Maria Giudetti Daniele Vergara Pietro Campiglia Rodolfo Sardone Margherita Curlo Mauro Mastronardi Katia Petroni Chiara Tonelli Angelo Santino Marcello Chieppa |
| author_facet | Marina Liso Annamaria Sila Giulio Verna Aurelia Scarano Rossella Donghia Fabio Castellana Elisabetta Cavalcanti Pasqua Letizia Pesole Eduardo Maria Sommella Antonio Lippolis Raffaele Armentano Anna Maria Giudetti Daniele Vergara Pietro Campiglia Rodolfo Sardone Margherita Curlo Mauro Mastronardi Katia Petroni Chiara Tonelli Angelo Santino Marcello Chieppa |
| author_sort | Marina Liso |
| collection | DOAJ |
| description | Antioxidants are privileged candidates for the development of adjuvants able to improve the efficiency of pharmacological therapies, particularly for chronic inflammatory syndromes. During the last 20 years, anti-TNFα (tumor necrosis factor alpha) monoclonal antibodies infusion has been the biological therapy most frequently administered but there is still large space for improvement in disease remission rates and maintenance. In this context, nutritional bioactive compounds contained in dietary patterns or included as supplements, may act as adjuvants for the induction and maintenance of IBD (inflammatory bowel diseases) remission. To verify this possibility, a single-center preliminary study (SI-CURA, Soluzioni Innovative per la gestione del paziente e il follow up terapeutico della Colite UlceRosA) was designed and carried out to evaluate whether a daily administration of purple corn supplement could improve the response to Infliximab (IFX) infusion of IBD patients with both Crohn’s disease (CD) and ulcerative colitis (UC). A cohort of 47 patients was enrolled in the study. Biological samples were collected before the first and the third IFX infusion. All patients received nutritional guidelines, 27 of them received commercial red fruit tea with low anthocyanins content, while 20 received a purple corn supplement with a high anthocyanin content. Results show that the administration of an antioxidant-enriched purple corn supplement could improve IFX-mediated disease remission in terms of circulating inflammatory markers. Comparison between CD and UC patients revealed that, at this anthocyanin dosage, the purple corn extract administration improved the IFX response in CD but not in UC patients. Our results may pave the way for a new metacentric study of CD patients, recruiting a wider cohort and followed-up over a longer observational time. |
| first_indexed | 2024-03-10T03:00:10Z |
| format | Article |
| id | doaj.art-cfd3dfa303854c43a73e127fafbf4540 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T03:00:10Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-cfd3dfa303854c43a73e127fafbf45402023-11-23T12:47:57ZengMDPI AGAntioxidants2076-39212022-01-0111113810.3390/antiox11010138Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot StudyMarina Liso0Annamaria Sila1Giulio Verna2Aurelia Scarano3Rossella Donghia4Fabio Castellana5Elisabetta Cavalcanti6Pasqua Letizia Pesole7Eduardo Maria Sommella8Antonio Lippolis9Raffaele Armentano10Anna Maria Giudetti11Daniele Vergara12Pietro Campiglia13Rodolfo Sardone14Margherita Curlo15Mauro Mastronardi16Katia Petroni17Chiara Tonelli18Angelo Santino19Marcello Chieppa20National Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyNational Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyDepartment of Pharmacy, School of Pharmacy, University of Salerno, 84084 Fisciano, ItalyUnit of Lecce, Institute of Sciences of Food Production C.N.R., 73100 Lecce, ItalyNational Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyNational Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyNational Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyNational Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyDepartment of Pharmacy, School of Pharmacy, University of Salerno, 84084 Fisciano, ItalyNational Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyNational Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyDepartment of Mathematics and Physics “Ennio De Giorgi”, University of Salento, via Monteroni, 73100 Lecce, ItalyDepartment of Mathematics and Physics “Ennio De Giorgi”, University of Salento, via Monteroni, 73100 Lecce, ItalyDepartment of Pharmacy, School of Pharmacy, University of Salerno, 84084 Fisciano, ItalyNational Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyNational Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyNational Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyDepartment of Biosciences, University of Milan, via Celoria 26, 20133 Milan, ItalyDepartment of Biosciences, University of Milan, via Celoria 26, 20133 Milan, ItalyUnit of Lecce, Institute of Sciences of Food Production C.N.R., 73100 Lecce, ItalyNational Institute of Gastroenterology Saverio de Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, ItalyAntioxidants are privileged candidates for the development of adjuvants able to improve the efficiency of pharmacological therapies, particularly for chronic inflammatory syndromes. During the last 20 years, anti-TNFα (tumor necrosis factor alpha) monoclonal antibodies infusion has been the biological therapy most frequently administered but there is still large space for improvement in disease remission rates and maintenance. In this context, nutritional bioactive compounds contained in dietary patterns or included as supplements, may act as adjuvants for the induction and maintenance of IBD (inflammatory bowel diseases) remission. To verify this possibility, a single-center preliminary study (SI-CURA, Soluzioni Innovative per la gestione del paziente e il follow up terapeutico della Colite UlceRosA) was designed and carried out to evaluate whether a daily administration of purple corn supplement could improve the response to Infliximab (IFX) infusion of IBD patients with both Crohn’s disease (CD) and ulcerative colitis (UC). A cohort of 47 patients was enrolled in the study. Biological samples were collected before the first and the third IFX infusion. All patients received nutritional guidelines, 27 of them received commercial red fruit tea with low anthocyanins content, while 20 received a purple corn supplement with a high anthocyanin content. Results show that the administration of an antioxidant-enriched purple corn supplement could improve IFX-mediated disease remission in terms of circulating inflammatory markers. Comparison between CD and UC patients revealed that, at this anthocyanin dosage, the purple corn extract administration improved the IFX response in CD but not in UC patients. Our results may pave the way for a new metacentric study of CD patients, recruiting a wider cohort and followed-up over a longer observational time.https://www.mdpi.com/2076-3921/11/1/138antioxidantanthocyaninsIBDdietinfliximabpilot study |
| spellingShingle | Marina Liso Annamaria Sila Giulio Verna Aurelia Scarano Rossella Donghia Fabio Castellana Elisabetta Cavalcanti Pasqua Letizia Pesole Eduardo Maria Sommella Antonio Lippolis Raffaele Armentano Anna Maria Giudetti Daniele Vergara Pietro Campiglia Rodolfo Sardone Margherita Curlo Mauro Mastronardi Katia Petroni Chiara Tonelli Angelo Santino Marcello Chieppa Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study Antioxidants antioxidant anthocyanins IBD diet infliximab pilot study |
| title | Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study |
| title_full | Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study |
| title_fullStr | Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study |
| title_full_unstemmed | Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study |
| title_short | Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study |
| title_sort | nutritional regimes enriched with antioxidants as an efficient adjuvant for ibd patients under infliximab administration a pilot study |
| topic | antioxidant anthocyanins IBD diet infliximab pilot study |
| url | https://www.mdpi.com/2076-3921/11/1/138 |
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