Poly(ethylene glycol)dimethacrylate – nanofibrillated cellulose bionanocomposites as injectable hydrogel for therapy of herniated nucleus pulposus patients
The highest disease caused by low back pain is herniated nucleus pulposus (HNP) where nucleus pulposus (NP) protrudes out through the annulus fibrosis. Injectable hydrogel is a method to restore NP function with minimal invasive surgery. Variation concentration of NFC were studied in detail toward a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-11-01
|
| Series: | Journal of Materials Research and Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785420317002 |
| _version_ | 1818563504581378048 |
|---|---|
| author | Prihartini Widiyanti Mochamad Arsyal Amali Aminatun |
| author_facet | Prihartini Widiyanti Mochamad Arsyal Amali Aminatun |
| author_sort | Prihartini Widiyanti |
| collection | DOAJ |
| description | The highest disease caused by low back pain is herniated nucleus pulposus (HNP) where nucleus pulposus (NP) protrudes out through the annulus fibrosis. Injectable hydrogel is a method to restore NP function with minimal invasive surgery. Variation concentration of NFC were studied in detail toward affects on PEGDMA (poly(ethylene glycol)dimethacrylate):NFC hydrogel mechanically and injectability. The characteristics of PEGDMA and nanofibrillated cellulose (NFC) based injectable hydrogels through the photoinitiator Irgacure 2959 in the formation of hydrogels with variations composition 1:0; 1:0.25; 1:0.5; 1:0.75. In the morphological test on NFC a fibre with a diameter of 100 nm was formed from the results of electrospinning on ethyl cellulose (EC). The FTIR showed of photopolymerization of the conjugation bond between Irgacure 2959 and PEGDMA producing C-C at a frequency of 1349.20 cm−1. Swelling test used phosphate buffer saline (PBS) fulfilled the standard at a variation of 1:0.25; 1:0.5; and 1:0.75, 87.07%, 84.84% and 80.42% respectively. Viscosity test in the injectability of hydrogels showed a result of 73.67 dPa.s. The compressive strength test obtained good results in samples 1:0.75 showed a result of 3.42 kPa. In vitro injection model showed increasing of NFC concentration indicates the gel state when released from agarose will be less rupture. PEGDMA/NFC hydrogel biocomposite has the potential to be applied as an injectable hydrogel for the treatment of HNP patients based on the results. |
| first_indexed | 2024-12-14T01:17:23Z |
| format | Article |
| id | doaj.art-cfd4ba10e1b540d4bc2843c145b9089b |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-12-14T01:17:23Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-cfd4ba10e1b540d4bc2843c145b9089b2022-12-21T23:22:33ZengElsevierJournal of Materials Research and Technology2238-78542020-11-01961271612722Poly(ethylene glycol)dimethacrylate – nanofibrillated cellulose bionanocomposites as injectable hydrogel for therapy of herniated nucleus pulposus patientsPrihartini Widiyanti0Mochamad Arsyal Amali1 Aminatun2Biomedical Engineering Program, Department of Physics, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia; Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia; Corresponding author.Biomedical Engineering Program, Department of Physics, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, IndonesiaPhysics Program, Department of Physics, Department of Physics, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, IndonesiaThe highest disease caused by low back pain is herniated nucleus pulposus (HNP) where nucleus pulposus (NP) protrudes out through the annulus fibrosis. Injectable hydrogel is a method to restore NP function with minimal invasive surgery. Variation concentration of NFC were studied in detail toward affects on PEGDMA (poly(ethylene glycol)dimethacrylate):NFC hydrogel mechanically and injectability. The characteristics of PEGDMA and nanofibrillated cellulose (NFC) based injectable hydrogels through the photoinitiator Irgacure 2959 in the formation of hydrogels with variations composition 1:0; 1:0.25; 1:0.5; 1:0.75. In the morphological test on NFC a fibre with a diameter of 100 nm was formed from the results of electrospinning on ethyl cellulose (EC). The FTIR showed of photopolymerization of the conjugation bond between Irgacure 2959 and PEGDMA producing C-C at a frequency of 1349.20 cm−1. Swelling test used phosphate buffer saline (PBS) fulfilled the standard at a variation of 1:0.25; 1:0.5; and 1:0.75, 87.07%, 84.84% and 80.42% respectively. Viscosity test in the injectability of hydrogels showed a result of 73.67 dPa.s. The compressive strength test obtained good results in samples 1:0.75 showed a result of 3.42 kPa. In vitro injection model showed increasing of NFC concentration indicates the gel state when released from agarose will be less rupture. PEGDMA/NFC hydrogel biocomposite has the potential to be applied as an injectable hydrogel for the treatment of HNP patients based on the results.http://www.sciencedirect.com/science/article/pii/S2238785420317002PhotopolymerizationInjectable hydrogelNano-fibrillated cellulosePoly(ethylene glycol)dimethacrylate |
| spellingShingle | Prihartini Widiyanti Mochamad Arsyal Amali Aminatun Poly(ethylene glycol)dimethacrylate – nanofibrillated cellulose bionanocomposites as injectable hydrogel for therapy of herniated nucleus pulposus patients Journal of Materials Research and Technology Photopolymerization Injectable hydrogel Nano-fibrillated cellulose Poly(ethylene glycol)dimethacrylate |
| title | Poly(ethylene glycol)dimethacrylate – nanofibrillated cellulose bionanocomposites as injectable hydrogel for therapy of herniated nucleus pulposus patients |
| title_full | Poly(ethylene glycol)dimethacrylate – nanofibrillated cellulose bionanocomposites as injectable hydrogel for therapy of herniated nucleus pulposus patients |
| title_fullStr | Poly(ethylene glycol)dimethacrylate – nanofibrillated cellulose bionanocomposites as injectable hydrogel for therapy of herniated nucleus pulposus patients |
| title_full_unstemmed | Poly(ethylene glycol)dimethacrylate – nanofibrillated cellulose bionanocomposites as injectable hydrogel for therapy of herniated nucleus pulposus patients |
| title_short | Poly(ethylene glycol)dimethacrylate – nanofibrillated cellulose bionanocomposites as injectable hydrogel for therapy of herniated nucleus pulposus patients |
| title_sort | poly ethylene glycol dimethacrylate nanofibrillated cellulose bionanocomposites as injectable hydrogel for therapy of herniated nucleus pulposus patients |
| topic | Photopolymerization Injectable hydrogel Nano-fibrillated cellulose Poly(ethylene glycol)dimethacrylate |
| url | http://www.sciencedirect.com/science/article/pii/S2238785420317002 |
| work_keys_str_mv | AT prihartiniwidiyanti polyethyleneglycoldimethacrylatenanofibrillatedcellulosebionanocompositesasinjectablehydrogelfortherapyofherniatednucleuspulposuspatients AT mochamadarsyalamali polyethyleneglycoldimethacrylatenanofibrillatedcellulosebionanocompositesasinjectablehydrogelfortherapyofherniatednucleuspulposuspatients AT aminatun polyethyleneglycoldimethacrylatenanofibrillatedcellulosebionanocompositesasinjectablehydrogelfortherapyofherniatednucleuspulposuspatients |