Impaired Vascular Endothelial Function is Associated with Peripheral Neuropathy in Patients with Type 2 Diabetes
Lingling Li,1,2 Ying Yang,1,2 Jia Bai,1,2 Yangyang Zhang,1,2 Hong Yang,1,2 Yuqi Zhang,1,2 Haihong Lv1 1Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of China; 2The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-05-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/impaired-vascular-endothelial-function-is-associated-with-peripheral-n-peer-reviewed-fulltext-article-DMSO |
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| author | Li L Yang Y Bai J Zhang Y Yang H Zhang Y Lv H |
| author_facet | Li L Yang Y Bai J Zhang Y Yang H Zhang Y Lv H |
| author_sort | Li L |
| collection | DOAJ |
| description | Lingling Li,1,2 Ying Yang,1,2 Jia Bai,1,2 Yangyang Zhang,1,2 Hong Yang,1,2 Yuqi Zhang,1,2 Haihong Lv1 1Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of China; 2The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of ChinaCorrespondence: Haihong Lv, Email haihonglv@126.comPurpose: It is believed that vascular endothelial dysfunction is involved in the occurrence of cardiovascular disease (CVD), and diabetic peripheral neuropathy (DPN) is associated with flow-mediated dilation (FMD), however, the correlation is still unclear. Aims of the present study is to explore the relationship between DPN parameters and FMD, providing a new approach for the prevention of CVD.Patients and Methods: A total of 272 patients with T2DM from the Department of Endocrinology of The First Hospital of Lanzhou University according to the grading criteria were selected. FMD was measured by a new vascular ultrasound system and patients were divided into FMD> 7%, 4%≤FMD≤ 7%, and FMD< 4% groups. The Toronto Clinical Scoring System (TCSS) was used to assess the severity of DPN. The nerve conduction studies (NCS) assessed large fibre neuropathy by nerve conduction velocity (CV), compound muscle action potential (CMAP) amplitude (Amp), and distal motor latency (DML). SPSS 25.0 was used for statistical analysis.Results: TCSS evaluation revealed that the percentage of patients with severe nerve injury was significantly higher in FMD< 4% (70%) compared to FMD> 7% (2%). Among the TCSS indicators of all subjects, the proportion of temperature disturbance was the most (73%), and joint position disturbance was the least (0). TCSS scores were negatively correlated with FMD (r=− 0.756, p< 0.001). More interesting, in FMD< 4% group, CV and Amp were positively correlated with FMD, while DML was negatively correlated (p< 0.05). Linear regression analysis model showed that different systolic blood pressure (SBP), triglyceride (TG), TCSS and CV had statistically different effects on FMD.Conclusion: High TCSS score and decreased CV of common peroneal and tibial nerves are risk factors of FMD injury, which provide potential value for timely prevention and treatment of cardiovascular diseases.Keywords: type 2 diabetes, diabetic peripheral neuropathy, vascular endothelial function, cardiovascular disease, Toronto clinical scoring system |
| first_indexed | 2024-03-12T05:01:14Z |
| format | Article |
| id | doaj.art-cfd71d2427324eaeb0c8ce73c536c020 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-12T05:01:14Z |
| publishDate | 2022-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-cfd71d2427324eaeb0c8ce73c536c0202023-09-03T09:12:20ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-05-01Volume 151437144975118Impaired Vascular Endothelial Function is Associated with Peripheral Neuropathy in Patients with Type 2 DiabetesLi LYang YBai JZhang YYang HZhang YLv HLingling Li,1,2 Ying Yang,1,2 Jia Bai,1,2 Yangyang Zhang,1,2 Hong Yang,1,2 Yuqi Zhang,1,2 Haihong Lv1 1Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of China; 2The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of ChinaCorrespondence: Haihong Lv, Email haihonglv@126.comPurpose: It is believed that vascular endothelial dysfunction is involved in the occurrence of cardiovascular disease (CVD), and diabetic peripheral neuropathy (DPN) is associated with flow-mediated dilation (FMD), however, the correlation is still unclear. Aims of the present study is to explore the relationship between DPN parameters and FMD, providing a new approach for the prevention of CVD.Patients and Methods: A total of 272 patients with T2DM from the Department of Endocrinology of The First Hospital of Lanzhou University according to the grading criteria were selected. FMD was measured by a new vascular ultrasound system and patients were divided into FMD> 7%, 4%≤FMD≤ 7%, and FMD< 4% groups. The Toronto Clinical Scoring System (TCSS) was used to assess the severity of DPN. The nerve conduction studies (NCS) assessed large fibre neuropathy by nerve conduction velocity (CV), compound muscle action potential (CMAP) amplitude (Amp), and distal motor latency (DML). SPSS 25.0 was used for statistical analysis.Results: TCSS evaluation revealed that the percentage of patients with severe nerve injury was significantly higher in FMD< 4% (70%) compared to FMD> 7% (2%). Among the TCSS indicators of all subjects, the proportion of temperature disturbance was the most (73%), and joint position disturbance was the least (0). TCSS scores were negatively correlated with FMD (r=− 0.756, p< 0.001). More interesting, in FMD< 4% group, CV and Amp were positively correlated with FMD, while DML was negatively correlated (p< 0.05). Linear regression analysis model showed that different systolic blood pressure (SBP), triglyceride (TG), TCSS and CV had statistically different effects on FMD.Conclusion: High TCSS score and decreased CV of common peroneal and tibial nerves are risk factors of FMD injury, which provide potential value for timely prevention and treatment of cardiovascular diseases.Keywords: type 2 diabetes, diabetic peripheral neuropathy, vascular endothelial function, cardiovascular disease, Toronto clinical scoring systemhttps://www.dovepress.com/impaired-vascular-endothelial-function-is-associated-with-peripheral-n-peer-reviewed-fulltext-article-DMSOtype 2 diabetesdiabetic peripheral neuropathyvascular endothelial functioncardiovascular diseasetoronto clinical scoring system |
| spellingShingle | Li L Yang Y Bai J Zhang Y Yang H Zhang Y Lv H Impaired Vascular Endothelial Function is Associated with Peripheral Neuropathy in Patients with Type 2 Diabetes Diabetes, Metabolic Syndrome and Obesity type 2 diabetes diabetic peripheral neuropathy vascular endothelial function cardiovascular disease toronto clinical scoring system |
| title | Impaired Vascular Endothelial Function is Associated with Peripheral Neuropathy in Patients with Type 2 Diabetes |
| title_full | Impaired Vascular Endothelial Function is Associated with Peripheral Neuropathy in Patients with Type 2 Diabetes |
| title_fullStr | Impaired Vascular Endothelial Function is Associated with Peripheral Neuropathy in Patients with Type 2 Diabetes |
| title_full_unstemmed | Impaired Vascular Endothelial Function is Associated with Peripheral Neuropathy in Patients with Type 2 Diabetes |
| title_short | Impaired Vascular Endothelial Function is Associated with Peripheral Neuropathy in Patients with Type 2 Diabetes |
| title_sort | impaired vascular endothelial function is associated with peripheral neuropathy in patients with type 2 diabetes |
| topic | type 2 diabetes diabetic peripheral neuropathy vascular endothelial function cardiovascular disease toronto clinical scoring system |
| url | https://www.dovepress.com/impaired-vascular-endothelial-function-is-associated-with-peripheral-n-peer-reviewed-fulltext-article-DMSO |
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