Acute pre-operative ibuprofen improves cognition in a rat model for postoperative cognitive dysfunction

Acute pre-operative ibuprofen improves cognition in a rat model for postoperative cognitive dysfunction

Abstract Background Inflammation is considered a key factor in the development of postoperative cognitive dysfunction (POCD). Therefore, we hypothesized that pre-operative anti-inflammatory treatment with ibuprofen would inhibit POCD in our rat-model. Methods Male Wistar rats of 3 or 23 months old r...

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Bibliographic Details
Main Authors: Klaske Oberman, Iris Hovens, Jacco de Haan, Joana Falcao-Salles, Barbara van Leeuwen, Regien Schoemaker
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Neuroinflammation
Subjects:
Cognition
Inflammation
Neuroinflammation
Ibuprofen
Postoperative cognitive dysfunction
Online Access:https://doi.org/10.1186/s12974-021-02206-y

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