Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana.
Individuals with sickle cell disease particularly with the homozygous (SS) genotype historically have relatively low blood pressure. Nonetheless, they develop vasculopathy-associated organ dysfunction and the risk of organ dysfunction increases at blood pressures that are normal in the general popul...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5754083?pdf=render |
| _version_ | 1819261614093762560 |
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| author | Amma Benneh-Akwasi Kuma Amma Twumwa Owusu-Ansah Mary Akua Ampomah Fredericka Sey Edeghonghon Olayemi Mehdi Nouraie Solomon Fiifi Ofori-Acquah |
| author_facet | Amma Benneh-Akwasi Kuma Amma Twumwa Owusu-Ansah Mary Akua Ampomah Fredericka Sey Edeghonghon Olayemi Mehdi Nouraie Solomon Fiifi Ofori-Acquah |
| author_sort | Amma Benneh-Akwasi Kuma |
| collection | DOAJ |
| description | Individuals with sickle cell disease particularly with the homozygous (SS) genotype historically have relatively low blood pressure. Nonetheless, they develop vasculopathy-associated organ dysfunction and the risk of organ dysfunction increases at blood pressures that are normal in the general population. This phenomenon is termed relative systemic hypertension (RSH) with a systolic blood pressure range of 120-139 mmHg, and diastolic blood pressure range of 70-89 mmHg. The significance of RSH lies in its association with renal insufficiency, pulmonary hypertension, stroke and propensity to progress to systemic hypertension. We conducted a retrospective chart review of 1,000 adults with sickle cell disease at the Ghana Institute of Clinical Genetics, to determine the prevalence of RSH in sickle cell disease in Ghana and associated complications. We found a high prevalence of RSH and hypertension with a relatively low frequency of renal insufficiency. Pulse pressure, a predictor of mortality, was higher in males of all ages. We anticipate that providing an estimate of the burden of RSH will heighten its recognition and clinical management among health care providers. |
| first_indexed | 2024-12-23T19:44:36Z |
| format | Article |
| id | doaj.art-cfd91dce770e4ded97dd6629f9a77d07 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T19:44:36Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cfd91dce770e4ded97dd6629f9a77d072022-12-21T17:33:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01131e019034710.1371/journal.pone.0190347Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana.Amma Benneh-Akwasi KumaAmma Twumwa Owusu-AnsahMary Akua AmpomahFredericka SeyEdeghonghon OlayemiMehdi NouraieSolomon Fiifi Ofori-AcquahIndividuals with sickle cell disease particularly with the homozygous (SS) genotype historically have relatively low blood pressure. Nonetheless, they develop vasculopathy-associated organ dysfunction and the risk of organ dysfunction increases at blood pressures that are normal in the general population. This phenomenon is termed relative systemic hypertension (RSH) with a systolic blood pressure range of 120-139 mmHg, and diastolic blood pressure range of 70-89 mmHg. The significance of RSH lies in its association with renal insufficiency, pulmonary hypertension, stroke and propensity to progress to systemic hypertension. We conducted a retrospective chart review of 1,000 adults with sickle cell disease at the Ghana Institute of Clinical Genetics, to determine the prevalence of RSH in sickle cell disease in Ghana and associated complications. We found a high prevalence of RSH and hypertension with a relatively low frequency of renal insufficiency. Pulse pressure, a predictor of mortality, was higher in males of all ages. We anticipate that providing an estimate of the burden of RSH will heighten its recognition and clinical management among health care providers.http://europepmc.org/articles/PMC5754083?pdf=render |
| spellingShingle | Amma Benneh-Akwasi Kuma Amma Twumwa Owusu-Ansah Mary Akua Ampomah Fredericka Sey Edeghonghon Olayemi Mehdi Nouraie Solomon Fiifi Ofori-Acquah Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana. PLoS ONE |
| title | Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana. |
| title_full | Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana. |
| title_fullStr | Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana. |
| title_full_unstemmed | Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana. |
| title_short | Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana. |
| title_sort | prevalence of relative systemic hypertension in adults with sickle cell disease in ghana |
| url | http://europepmc.org/articles/PMC5754083?pdf=render |
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